大肠癌靶向药物治疗进展评述

21世纪以来,靶向药物如抗VEGF的人源化单克隆抗体(Bevacizumab,贝伐单抗)和抗EGFR单克隆抗体(人鼠嵌合性单抗Cetuximab,C225,西妥昔单抗和全人源化单抗EGFR抗体,Panitumumab,帕尼单抗)的临床应用,已使复发转移性结直肠癌患者的总生存取得了长足的进步,但临床上应如何更加合理有效地使用这些药物,仍有许多亟待解决的问题。     

重视直肠癌术后局部复发的防治

直肠癌术后局部复发是临床关注的重点与难点问题。术前准确分期、评估,选择合理治疗方案和术式,是防治局部复发的先决条件。手术遵循全直肠系膜切除(TME)原则,保证断端切缘和环周切缘完整、无癌细胞残留是防治局部复发的关键。新辅助治疗可降低T3、T4期直肠癌局部复发率。发挥直肠癌多学科综合治疗模式优势对防治直肠癌局部复发有重要作用。     

On the Constitution and the True Aim of The Joy of Heaven and Non-Speech： A Reinterpretation of the Debate at the Dam over the Hao River

The essay starts by questioning how the debate at the dam over the Hao River between Zhuang Zi and Hui Zi arose. It describes the source of ideas that led Zhuang Zi to speak on the enjoyment of the fish (yuzhile 鱼之乐) and points out that the meaning of the debate rests in bringing about the emergence of the true subject of “enjoyment.” It highlights this meaning by analyzing the essential content and value orientation of Zhuang Zi’s ideas on the joy of heaven (tian le 天乐) and perfect enjoyment (zhile 至乐). Following up on this thread, the essay goes further to analyze the true meaning of Zhuang Zi’s theory concerning the “great speech” of “non-speaking.” This essay holds that the debate is a parable, an external representation that unfolds an internal tension between two different levels contained within Zhuang Zi’s thought, rather than simply a debate between these two thinkers.     

初中生感戴和主观幸福感的干预研究

该研究通过开设班级辅导和“列举恩惠”活动,采用不同的干预方式对初一年级学生进行感戴干预研究,考察不同感戴干预方式对主观幸福感的影响。结果显示：实验班1学生在感戴、生活满意度、积极情感方面的提高水平高于实验班2和控制班;实验班2学生在感戴、生活满意度、积极情感方面的提高水平高于控制班。因此得出结论：班级辅导和“列举恩惠”活动相结合的干预方式与仅采用“列举恩惠”活动的干预方式都可以提高学生感戴和主观幸福感,但是前者比后者的效果好。     

人格分化的智力假设

人格与智力是个体差异中相互关联的两个重要方面,人格随智力水平的提高而不断分化,智力影响了特定人格维度之间的相关。尽管人格分化的智力假设尚未获得一致性的证据,但它却暗示了智力对人格结构的潜在影响。由于人格测量工具的信度和效度可能因受测者的能力水平而异,因此未来的研究应在使用统一测量工具的基础上,尽量扩大被试的能力范围,采用多重评估或集合评定的方法,使人格测量真正独立于受测者的认知能力。     

焦虑个体“冷”、“热”执行功能Stroop效应量比较

该文采用Stroop实验范式对筛选出的49名高焦虑个体和48名低焦虑个体的“冷”、“热”执行功能进行测量,以探讨不同焦虑程度个体“冷”、“热”执行功能间的差异。结果表明,在“冷”执行功能方面,高焦虑个体与低焦虑个体Stroop效应量之间没有显著差异;在“热”执行功能方面,两组被试情绪Stroop的效应量无差异;两类词;12的Stroop效应量差异显著;词汇类型×被试类型的交互作用非常显著;进一步的简单效应分析表明,两组被试的情绪Stroop效应量在消极词汇水平差异显著,两类词汇Stroop效应量在低焦虑组差异显著。说明高、低焦虑个体在“冷”执行功能上没有显著差异,高焦虑个体的“冷”执行功能正常,而“热”执行功能下降,表现为高焦虑个体对两极情绪的趋避关系失调,即对消极情绪具有偏向性,对积极情绪具有回避性。     

晚期癌症患者治疗决策的思考

现代医疗尚无法治愈所有晚期癌症。现实与期望之间的较大差距,挑战晚期癌症治疗的临床决策。WHO强调为防止资源滥用,应确保抗癌治疗只用于可获益阶段。对于晚期癌症患者的治疗决策,除遵循规矩原则和循证医学证据原则外,还应该遵循尊重患者意愿、社会公平的美德原则。大多数癌症患者需要接受姑息治疗。姑息治疗为患者及家属提供既简便又经济的医疗服务。     

MUSLIM PERSPECTIVES ON STEM CELL RESEARCH AND CLONING

In Islam, the acquisition of knowledge is a form of worship. But human achievement must be exercised in conformity with God's will. Warnings against feelings of superiority often are coupled with the command to remain within the confines of God's laws and limits. Because of the fear of arrogance and disregard of the balance created by God, any new knowledge or discovery must be applied with careful consideration to maintaining balance in the creation. Knowledge must be applied to ascertain equity and justice for all of humanity. Research in Islam must be linked to the broad ethical base set forth in the Qur'an and the Sunnah. Whether embryonic stem cell research or cloning is ethically acceptable in Islam depends on the benefits derived from such applications. What is most important for the scholars is to adhere to the concepts of compassion, mercy, and benefit to everyone.     

‘But everyone else is doing it’: a closer look at the occupational taxpaying culture of one business sector

When individuals embark on their careers they not only become acculturated into their occupational sectors' day‐to‐day norms and practices, but also their taxpaying ones. Although the research on taxpaying cultures is still in its infancy, understanding more about taxpaying cultures could improve our understanding of the processes underlying tax compliance. To this end, this study aimed to build a detailed picture of the taxpaying culture (i.e. the norms and values) of one business sector—the hairdressing/beauty industry. Nineteen small business and self‐employed hairdressers/beauticians were interviewed and a variant of Grounded theory was used to uncover the main themes that ran through the interviews as a whole. The main themes that emerged—which appear to characterize this sector's culture—include a reliance on accountants/tax advisors, the notion of an acceptable level of cash‐in‐hand payments, and the use of different mental accounts for different types of income. Although some of these themes have already arisen in the small business literature they have often been couched in individualistic terms. We build a case that these issues are more cultural than individual—they are tied to occupational group membership as they are socially constructed within occupational groups and are a key component of the group's taxpaying culture. Implications and directions for future research are discussed. Copyright © 2007 John Wiley & Sons, Ltd.     

住院放化疗肺癌患者生活质量影响因素分析

生活质量研究是近年来肿瘤治疗研究的热点之一。应用生存质量核心问卷（QLQ—C30）及卡氏功能量表,于治疗前、中、后进行问卷式调查,探讨60例经病理证实接受放、化疗的肺癌患者生活质量的影响因素,预测患者预后和远期生存状态,为住院放化疗肺癌的治疗方法提供一个较好的参考标准,对放化疗肺癌的治疗水平和改善生活质量起到了一定的推动作用。