转化医学与肿瘤诊治

转化医学是促进基础研究成果向临床应用转化和根据临床医学的需求从事应用基础研究的桥梁。本文以转化医学在肿瘤防治研究的实例,分析转化医学的意义,以期为使大家重视转化医学,提高肿瘤诊治水平。     

外科临床决策的核心在精于选择

造就名医是个系统工程,理论和实践统一才有功底。为病人提供优质服务,要求医生有能力对病情进行综合分析思考、辨认、评估,对诊断、治疗进行鉴别,为选择科学的临床决策提供依据。理论与临床实践高水平的结合,难能可贵的是忌粗取精、忌浅求深、忌表识里,从临床汇集资料来思考、分析,最终做出选择,再到临床上去验证,从而得出正确的诊断和处理方案。善于选择和精于选择,是临床决策的核心,是临床医生综合素质走向成熟的产物,是一代名医成长的必然之路。     

The Survivor Health and Resilience Education (SHARE) Program: Development and Evaluation of a Health Behavior Intervention for Adolescent Survivors of Childhood Cancer

Few evidence-based health behavior interventions for adolescent survivors of childhood cancer currently exist. These interventions are necessary to address a range of lifestyle and behavioral factors (e.g., diet and physical activity, tobacco and alcohol use, excessive sun exposure) that may place survivors at increased risk for secondary cancers other chronic diseases. To address this need, the development and evaluation of a health promotion and disease prevention program for childhood cancer survivors is described, with an emphasis on the steps leading up to conducting a randomized controlled trial to test its efficacy. Data gathered from trial participants suggest the preliminary evaluation of the intervention is favorable. Trends and future directions in behavioral intervention research with childhood cancer survivors are discussed, along with the role of behavioral research in health promotion and disease prevention.     

家庭游戏中的母亲控制策略与儿童顺从行为

以42个3岁儿童及其母亲为被试,考察在家庭自由游戏中母亲的控制策略和儿童的顺从行为之间的关系。结果表明：（1）在亲子交往中,母亲使用直接命令的频次最多,间接命令次之,否定控制最少。（2）3岁儿童对母亲控制的顺从率为56．1％;在儿童的不顺从行为中,无技巧不顺从占优势,其中消极不顺从的频次最多。（3）母亲的弱控制策略与儿童的顺从行为相关最高;强控制策略与儿童的无技巧不顺从相关最高。（4）在儿童不顺从时,母亲的弱控制策略容易导致儿童的顺从行为,强控制策略则容易导致儿童的情境性顺从行为。     

Conversation: The challenges of teaching in a “nano department”

A panel at the 2016 American Academy of Religion conference staged, taped, transcribed, and edited this conversation about the challenges and opportunities of teaching in a “nano department” – an undergraduate religion or religious studies department (or combined religion and philosophy department) with only one, two, or three faculty members. Two things quickly become evident: one is the impossibility of coverage of the full religious studies curriculum, and the other is the necessity for collaboration with other departments. Neither of these is unique to nano departments, but there exists an intimacy between students and faculty in small departments, a necessary freedom to rethink the place of the study of religion in the liberal arts curriculum, and a disruptive value in what can be critiqued and contributed from a marginalized position. Arguably, nano departments are the canaries in the academic coal mine, charting the future of the humanities that cannot be discerned from the vantage point of Research‐1 contexts.     

Do stigma and its psychosocial impact differ between Asian-born Chinese immigrants and Western-born Caucasians with head and neck cancer?

Stigma appears to influence emotional distress and well-being in cancer survivors, but cross-cultural differences have been ignored. Previous studies suggest that stigma may be especially relevant for survivors of Asian origin. However, their study designs (e.g. focused on female cancers, qualitative designs, and an absence of comparison groups) limit the strength of this conclusion. We hypothesized that (1) Asian-born Chinese immigrants (AI) would report more perceived cancer-related stigma than Western-born Caucasians (WBC); and (2) the impact of stigma on emotional distress and well-being would be greater in AI as compared to WBC. Head and neck cancer survivors (n = 118 AI and n = 404 WBC) completed measures of well-being, emotional distress, and a three-item indicator of stigma in structured interviews. The majority of respondents (59%) reported one or more indicators of stigma. Stigma correlated significantly with emotional distress (r = .13, p = .004) and well-being (r = ?.09, p = .032). Contrary to our hypotheses, WBCs and AIs did not differ in reported stigma nor did we detect differences in its psychosocial impact. Stigma exerts a deleterious psychosocial impact on head and neck cancer survivors. It did not differ significantly between AI and WBC survivors.     

癌症患者健康赋权能力的研究现状

追溯赋权的起源及其概念的演变,全面研究健康赋权的内涵及其对癌症患者的重要性。通过总结癌症患者健康赋权的测评工具、相关影响因素、促进健康赋权策略三个方面,了解国内外癌症患者健康赋权研究与实施的关键点与未来挑战,以期为探索适合我国癌症患者健康赋权的专科评估、干预模式构建和护理实践提供依据,以提高患者对健康相关知识的掌握,促使患者与医务人员共同规划、设计医疗保健行为,并最终实现以患者为中心的医疗服务理念,促进医疗系统的可持续发展。

     

心理行为干预对乳腺癌患者情绪反应及免疫功能的影响

按随机和匹配原则,将40名乳腺癌放疗患者分入干预组和对照组。对干预组患者进行为期4周的心理行为干预,对照组仅接受相应的医药治疗。以肿瘤病人情绪适应问卷(MAC)和免疫测试法研究患者干预前后的情绪反应和免疫功能,探讨心理行为干预对乳腺癌患者情绪反应和免疫功能的影响。结果发现,心理行为干预有利于提高患者NK细胞活性(NKCA);并有助于维持放疗期间患者的白细胞水平。     

An empirical study of the diathesis-stress theory of disease

One thousand, one hundred and twenty-one Jewish concentration camp survivors were compared with 367 Jewish controls who had not been in a concentration camp, and had not lost any family members in such a camp. Of interest was the mortality of camp and comparison groups, on the hypothesis that the stress of being in a camp would adversely affect inmates. It was found that former camp inmates were over twice as likely to die of cancer, coronary heart diesease, or other causes as the comparison subjects of similar age and sex composition, and that severity of stress was correlated with mortality in the expected direction. Diathesis, determined by means of a special interviewer-administrated questionnaire, was found to interact synergistically with stress in producing high mortality.     

The Implicit Image of God: God as Reality and Psychological Well‐Being

Research has widely demonstrated that religiosity is related to psychological well‐being even in situations of severe illness. To assess religious beliefs, explicit measures have generally been used. In this study, we measured the belief that God is reality as opposed to myth or abstraction by using an implicit technique (the Single Category Implicit Association Test). The study was carried out in Italy, where a large majority of the population is Catholic, and the prevailing image of God is that of a compassionate and supportive father. Participants were cancer patients identifying themselves as believers. As expected, the automatic belief that God is reality (vs. abstraction) was related to beneficial outcomes: lower reported psychophysical anxiety symptoms and a weaker use of avoidance strategies to cope with stress. Thus, also, automatic religious beliefs may affect feelings and behaviors.