Nonparticipation in Huntington's Disease Predictive Testing: Reasons for Caution in Interpreting Findings

When given the opportunity to clarify their genetic status, most individuals at risk for Huntington's disease (HD) currently show a preference not to know. Our understanding of the characteristics of those who do not request HD predictive testing, and the factors influencing their decision, lags behind our knowledge of test applicants. In the light of our experience with interviewing a random sample of nonparticipants in an ongoing study, we critically analyze research concerning the differences between participants and nonparticipants in HD predictive testing programs and the interpretive characterization of these two groups. The findings concerning nonparticipants are limited to a small sample of the at-risk population, with the problems of biased samples and low response rates. We discuss this and other aspects of research in this area, notably the context and timing of data collection and the predominantly questionnaire-based methodology, that lead us to interpret the conclusions drawn about these two groups with caution.     

从人脑到计算机─—鸿沟能否逾越

人类对人脑及其精神活动过程的彻底了解,意味着哲学上的根本性事件的发生。所谓彻底的了解,标志就是人类对这种精神活动的成功模拟和再现。作为神经科学的分支和广延的人工智能的兴起,使人类有理由希望：存在于人脑与计算机之间的鸿沟终将被人类逾越。     

PROMPTING TECHNIQUES TO INCREASE THE RETURN RATE OF MAILED QUESTIONNAIRES1

To increase the return rate of questionnaires mailed to clergy and physicians concerning their mental-health practices, different prompts were used after the questionnaire was received during four mail-outs to four randomly drawn samples of clergy and physicians. For each mail-out, the sample was divided into experimental (received prompt) and comparison (no prompt) groups, and one type of prompt or combination was used. Non-returnees of the questionnaire in the experimental group received either: (a) a single telephone call, (b) a memo, (c) a package (personal letter and new questionnaire) or package plus a telephone call, or (d) a double call. Comparison physicians and clergy were mailed only the original questionnaire. Relative to their respective comparison group's return rate, which averaged 22% across the four mail-outs (range 18% to 24%), the single call and package alone about doubled the overall return rate, the package and call increased the return rate about two-and-a-half fold, and the double call almost tripled the return rate. The memo was ineffective. A cost-effectiveness analysis indicated that the double-call procedure was less expensive than the single call, and much less expensive than the package alone or package with a call in securing returns. An analysis of the pattern of returns showed clearly that when prompts were not delivered (comparison groups), very few returns were received after about seven days from the initial mail-out. Most returns from prompts (experimental groups) were received by several days after the prompt. The results were seen as salient to the problem of reducing selection or volunteer bias in questionnaire studies and subsequent research demonstrating the effectiveness of telephone calls made about a week after distribution of surveys in securing high return rates was discussed.     

Research in person‐centred,experiential and humanistic counselling and psychotherapy: Meeting new challenges

As a result of the programme of research into client‐centred therapy led by Carl Rogers, the humanistic therapies could claim, in the 1950s, to possess a comprehensive evidence base. Over the following decades, however, there was a marked decline in the productivity and influence of research into person‐centred and humanistic therapies. The present paper celebrates the publication of three books that mark a resurgence in research into these approaches, and comments on emerging themes and trends.     

Understanding Cognition Through Large-Scale Cortical Networks

An emerging body of evidence from a number of fields is beginning to reveal general neural principles underlying cognition. The characteristic adaptability of cognitive function is seen to derive from large-scale networks in the cerebral cortex that are able to repeatedly change the state of coordination among their constituent areas on a subsecond time scale. Experimental and theoretical studies suggest that large-scale network dynamics operate in a metastable regime in which the interdependence of cortical areas is balanced between integrating and segregating activities. Cortical areas, through their coordination dynamics, are thought to rapidly resolve a large number of mutually imposed constraints, leading to consistent local states and a globally coherent state of cognition.     

Infant Attention Grows Up: The Emergence of a Developmental Cognitive Neuroscience Perspective

Visual attention has long been regarded as a tool for studying the development of basic cognitive skills in infancy and early childhood. However, over the past decade, the development of attention in early life has emerged as an important topic of research in its own right. This essay describes recent changes in the methods used to study attention in infancy, and in the nature of inferences about the early development of attention, as both research and theory in the area have become progressively integrated with models of attention from cognitive science and neuroscience.     

Notes for a dialogue between psychoanalysis and neuroscience1

The author postulates that the dialogue between psychoanalysis and neuroscience is based on the assumption that both deal with virtual structures. They are two facets of the same noumenal reality, but with different phenomenal realities, and it is possible to use metapsychology as a lingua franca to develop communication between the two fi elds. In the second part of the paper, the author refl ects on the results of recent neurophysiological research which seem to offer to psychoanalysis possibilities for fi nding an anatomical‐physiological correlate of some well‐known psychic phenomena and mechanisms, such as imitation, introjection, identifi cation, empathy, identity, mother‐child communication, learning, social communication and the analyst‐patient relationship. Particular neurons, called mirror neurons, have been located in the F5 area of baboons' brains. They are also present in man's brain within Broca's area. These neurons activate our motor system during both the performance of actions and the observation of actions performed by others giving rise to an automatic response, a sort of simulation or, rather, imitation, as the process is not intentional, but automatic and unaware, that is, unconscious.     

时间洞察力的概念及研究方法

对时间洞察力的概念和研究方法进行了总结、辨析和阐述,认为时间洞察力是一种相对稳定的个体差异变量,是个体在对时间的认知、体验和行动(或行动倾向)上所表现出的人格特质。并对时间洞察力的概念界定和方法学方面存在的问题进行了反思。     

PIONEER IN BEHAVIORAL PHARMACOLOGY: A TRIBUTE TO JOSEPH V. BRADY

The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner (conditioned emotional response) procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile methadone treatment services and to small group behavioral analyses in simulated space environments. This expansive range of activities is based on Brady's insight and innovative use of behavioral procedures, his spirited and unabashed enthusiasm for the discipline and its philosophical underpinnings, together with a collegiality and commitment to the experimental analysis of behavior that is both legendary and inspirational. These contributions are summarized and highlighted in this tribute that focuses primarily on Brady's contributions to behavioral pharmacology but which also acknowledges his conceptual and technical contributions spanning multiple disciplines.