Differential cognitive substrates of verbal episodic memory performance in semantic variant primary progressive aphasia and Alzheimer’s disease

Performance on neuropsychological measures of verbal memory requires cognitive abilities beyond memory. We examined the contribution of semantic knowledge in verbal episodic memory for semantic variant primary progressive aphasia (svPPA) or Alzheimer’s disease (AD). 415 AD and 68 svPPA participants completed measures of episodic memory (visual and verbal) and semantic knowledge. A double dissociation existed visual recall predicted verbal recognition in AD, whereas semantic knowledge contributed to verbal recognition in svPPA.     

Suitability of published neuropsychological test norms for urban African secondary school students in South Africa

Variations in neuropsychological test performance as a function of ethnic/cultural group membership, socioeconomic and educational status are widely documented. In South Africa, issues of cultural difference, sociopolitical disadvantage, cognitive and educational limitations, are of particular relevance. Accordingly, this study investigated the performance on a neuropsychological test battery of urban African high school students. A group of 100 Soweto students in Grades 8–12, and a second group of 152 sixth grade Soweto students aged 13–15 years, scored significantly lower on most of the measures than their American counterparts, as reflected in published norms. Results also demonstrated a significant difference in test performance as a function of educational grade. The findings confirmed the need for using norms and approaches which are appropriate to a given population when interpreting and addressing neuropsychological test performance.     

类别学习的神经心理学研究

类别学习的神经心理学研究是检验类别学习理论的一种有效研究范式,它有助于我们对类别学习理论的深入理解,以及对认知活动过程和脑机制的认识。作者对基底神经节功能障碍患者、遗忘症患者和其他类型的神经症患者的类别学习研究进行了回顾,对这些研究可能存在的单系统理论和多系统理论解释进行了讨论,并指出了研究中可能存在的取样偏差问题和未来研究中需要在研究手段、研究设计、被试取样等方面加以改进的建议     

视知觉神经心理障碍的内隐和外显加工分离及其神经基础

外显和内隐认知功能区别的关键是有无意识觉察的出现,脑损伤神经心理障碍为探讨内隐/外显加工的“纯净”分离提供了可能。通过对典型的视知觉神经障碍中的盲视、认识不能、单侧忽视的内隐和外显加工分离的实验证据及其神经基础的探讨,证明了视知觉神经心理障碍的内隐加工完好和外显加工损伤之间的分离,说明内隐和外显加工有着不同的神经基础,但这种分离的神经基础是什么以及这种分离的本质还有待于进一步的研究。视知觉神经心理障碍的内隐/外显加工的反向损伤是没有进行研究的领域。     

虚拟现实技术在执行功能评估中的应用

执行功能反映了个体对自身的认知过程进行调节和控制的能力,其评估在儿童认知能力发展水平和特殊人群认知功能损伤程度的评定中起着重要作用。虽然执行功能的评估自20世纪初就开始被实施和应用,但传统评估方法仍存在着生态效度不高、不易操纵实验环境的复杂性、不易操纵被试觉醒水平等缺陷。近年来,虚拟现实技术以其有限的成本和快速的发展被越来越多地应用于执行功能评估,并被证实具有生态效度高、实验条件高度可控等显著优点。     

The interplay among temperament,neuropsychological abilities,and global functioning in young hyperactive/inattentive children

Cognition and emotion have been shown to interact and influence psychological functioning. However, to date these interactions have only been examined cross‐sectionally among inattentive and/or hyperactive/impulsive children. This study investigated the moderating effects of neuropsychological functioning at age 3–4 years on the relation between negative emotionality at age 3–4 years and global functioning 1 year later, at age 4–5 years. Hyperactive/inattentive (H/I; n = 114) preschoolers entered the study (BL: baseline) and were seen again 1 year later (F1). Children's BL scores on a neuropsychological test (NEPSY) and their temperament as rated by parents (Child Behavior Questionnaire) and teachers (Temperament Assessment Battery for Children‐Revised) were obtained, as were clinicians’ ratings of their global functioning (Children's Global Assessment Scale) at F1. Hierarchical linear regression analyses revealed that BL temperament variables accounted for significant variance in F1 Global Functioning. Significant interactions indicated that higher Verbal Executive abilities were associated with better child functioning when parent‐rated Effortful Control was high, but not when Effortful Control was low. Additionally, high levels of Nonverbal Executive skills were associated with higher child global functioning when both parent‐ and teacher‐rated negative affect was low, but not when negative affect was high.     

How impaired is too impaired? Exploring futile neuropsychological test patterns as a function of dementia severity and cognitive screening scores

Some older adults cannot meaningfully participate in the testing portion of a neuropsychological evaluation due to significant cognitive impairments. There are limited empirical data on this topic. Thus, the current study sought to provide an operational definition for a futile testing profile and examine cognitive severity status and cognitive screening scores as predictors of testing futility at both baseline and first follow-up evaluations. We analysed data from 9,263 older adults from the National Alzheimer’s Coordinating Center Uniform Data Set. Futile testing profiles occurred rarely at baseline (7.40%). There was a strong relationship between cognitive severity status and the prevalence of futile testing profiles, χ²(4) = 3559.77, p < .001. Over 90% of individuals with severe dementia were unable to participate meaningfully in testing. Severity range on the Montreal Cognitive Assessment (MoCA) also demonstrated a strong relationship with testing futility, χ²(3) = 3962.35, p < .001. The rate of futile testing profiles was similar at follow-up (7.90%). There was a strong association between baseline dementia severity and likelihood of demonstrating a futile testing profile at follow-up, χ²(4) = 1513.40, p < .001. Over 90% of individuals with severe dementia, who were initially able to participate meaningfully testing, no longer could at follow-up. Similarly, there was a strong relationship between baseline MoCA score band and likelihood of demonstrating a futile testing profile at follow-up, χ²(3) = 1627.37, p < .001. Results can help to guide decisions about optimizing use of limited neuropsychological assessment resources.     

Effects of literacy on semantic verbal fluency in an immigrant population

Objective: A significant impact of limited schooling and illiteracy has been found on numerous neuropsychological tests, which may partly be due to the ecological relevance of the tests in the context of illiteracy. The aims of this study were to compare the performance of illiterate and literate immigrants on two semantic criteria for the verbal fluency test, and examine the influence of acculturation on test performances.

Method: Performances of 20 cognitively unimpaired illiterate and 21 literate Turkish immigrants aged ≥50 years were compared on an animal and supermarket criterion for the semantic verbal fluency test. Also, the influence of acculturation on test performances was examined.

Results: Significantly poorer performance of the illiterate compared to the literate group was found for the animal criterion, whereas no differences were found for the supermarket criterion that was considered more ecologically relevant for illiterate individuals. A significant interaction effect was found between the semantic criteria and literacy group, which was mainly related to a large effect of semantic criteria within the illiterate group. Adjusting for years of residence in Denmark and acculturation score did not affect this interaction effect.

Conclusions: Overall, our results are in line with previous studies comparing semantic fluency in illiterate and literate individuals. The results lend further support to the strong associations between literacy, semantic verbal fluency performance and ecological relevance of the semantic criterion and extend previous findings to immigrants with different cultural experiences related to the acculturation process.     

The effects of HIV disease and older age on laboratory-based,naturalistic, and self-perceived symptoms of prospective memory: does retrieval cue type and delay interval matter?

There is a rising prevalence of older HIV+ adults who are at risk of deficits in higher order neurocognitive functions and associated problems in everyday functioning. The current study applied multiprocess theory to examine the effects of HIV and aging on measures of laboratory-based, naturalistic, and self-perceived symptoms of prospective memory (PM). Participants included 125 Younger (48 with HIV, age = 32 ± 4.6 years) and 189 Older (112 with HIV, age = 56 ± 4.9 years) adults. Controlling for global neurocognitive functioning, mood, and other demographics, older age and HIV had independent effects on long-delay time-based PM in the laboratory, whereas on a naturalistic PM task older HIV? adults performed better than older HIV+ adults and younger persons. In line with the naturalistic findings, older age, but not HIV, was associated with a relative sparing of self-perceived PM failures in daily life across longer delay self-cued intervals. Findings suggest that, even in relatively younger aging cohorts, the effects of HIV and older age on PM can vary across PM delay intervals by the strategic demands of the retrieval cue type, are expressed differently in the laboratory and in daily life, and are independent of other higher order neurocognitive functions (e.g., retrospective memory).     

Cultural conceptions of a bereavement-related illness in a South African indigenous community

This study explored cultural conceptions of a bereavement-related illness among elderly (aged 34–85yrs) Northern Sotho-speaking people in Limpopo province. The participants (n = 14, females = 50%, mean age = 59 years, SD: 13.7 years) were purposively selected and interviewed using in-depth interviews. Data were analysed using Hycner’s adapted phenomenological method. Three themes emerged from the analysis: debilitating and life-threatening symptoms of the illness; aetiology explained by ritual taboo violations; and management of the illness through ritual cleansing. The cleansing process incorporates the administration of traditional herbs. The findings suggest bereavement-related illness in an African cultural community to be explained by their cultural concept of distress understandings.