Not Just “Study Drugs” for the Rich: Stimulants as Moral Tools for Creating Opportunities for Socially Disadvantaged Students

An argument in the cognitive enhancement literature is that using stimulants in populations of healthy but socially disadvantaged individuals mistakenly attributes pathology to nonpathological individuals who experience social inequalities. As the argument goes, using stimulants as cognitive-enhancing drugs to solve the social problem of poorly educated students in inadequate schools misattributes the problem as an individual medical problem, when it is really a collective sociopolitical problem. I challenge this argument on the grounds that not all types of enhancement have to be explained in medical terms, but rather at least one conception of enhancement can be explained in social terms—opportunity maintenance. Therefore, I propose that as a moral requirement we ought to explore whether stimulants could be a means of remedying underprivileged children's experiences of social inequalities that are borne from inadequate schools for the sake of increasing their chances for opportunities and well-being.     

聋人副中央凹字N+1预视效益的眼动研究

聋人听觉受损后,在低水平的视觉认知任务中,表现出副中央凹注意增强效应。这种增强效应是否也会发生在高水平的汉语认知加工任务中？本研究采用边界范式,探究副中央凹注意增强效应对聋人读者合体字N+1预视效益的影响。研究发现,高技能聋人读者,可以获得合体字N+1语音和语义预视效益。研究表明,副中央凹注意增强促进了高技能聋人读者N+1预视信息的获得。     

Making sense of positive self‐evaluations in China: The role of sociocultural change

Recent research points to Chinese people's elevated tendency to make positive self‐evaluations, despite the general claim that East Asians do not self‐enhance. We present three studies in support of a novel prediction that sociocultural change in China plays an important role in augmenting self‐enhancement. We operationalized self‐enhancement primarily in terms of the better‐than‐average effect (BTAE) and accounted for trait desirability or importance. We found that: (i) compared with Chinese Canadians, Chinese showed a stronger BTAE; (ii) within the Chinese, identification with contemporary Chinese culture uniquely predicted a stronger BTAE; and (iii) priming contemporary (vs. traditional) Chinese culture led to a stronger BTAE. Finally, we provided further evidence that motivation, in part, underlies the rising Chinese BTAE. We conclude by discussing the importance of both socioeconomic and cultural perspectives for understanding how and when of self‐enhancement in contemporary China and other societies undergoing social change.     

生殖细胞基因增强技术的伦理争议与对策

分析生殖细胞基因增强的概念,论述支持和反对生殖细胞基因增强的理由,初步探讨伦理学对策.在人类理性的指引下,生殖细胞基因增强能够成为造福人类的有力武器.     

Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms

Behavioural characterisation of transgenic mice has been instrumental in search of therapeutic targets for the modulation of cognitive function. However, little effort has been devoted to phenotypic characterisation across environmental conditions and genomic differences such as sex and strain, which is essential to translational research. The present study is an effort in this direction. It scrutinised the stability and robustness of the phenotype of enhanced Pavlovian conditioning reported in mice with forebrain neuronal deletion of glycine transporter 1 by evaluating the possible presence of sex and circadian dependency, and its consistency across aversive and appetitive conditioning paradigms. The Pavlovian phenotype was essentially unaffected by the time of testing between the two circadian phases, but it was modified by sex in both conditioning paradigms. We observed that the effect size of the phenotype was strongest in female mice tested during the dark phase in the aversive paradigm. Critically, the presence of the phenotype in female mutants was accompanied by an increase in resistance to extinction. Similarly, enhanced conditioned responding once again emerged solely in female mutants in the appetitive conditioning experiment, which was again associated with an increased resistance to extinction across days, but male mutants exhibited an opposite trend towards facilitation of extinction. The present study has thus added hitherto unknown qualifications and specifications of a previously reported memory enhancing phenotype in this mouse line by identifying the determinants of the magnitude and direction of the expressed phenotype. This in-depth comparative approach is of value to the interpretation of behavioural findings in general.     

基于ERP的二语句子加工过程的认知神经机制研究进展及其启示

二语句子加工认知神经机制的研究尚处于验证和探索阶段,基本上还集中于对一语和二语的语义违例与句法违例反应的比较,更缺乏动态的二语句子加工认知神经机制的研究。仅就二语语义加工而言,所得结果充满矛盾,这可能与二语习得年龄有关。就二语句法加工研究而言,二语学习者显示出依赖于二语学习年龄的不同模式。同时,二语的句法加工过程依赖于二语和一语的相似性与相异性。其深层原因可能意味着存在一语和二语之间的句法通达问题。为此,应当系统考察语义通达程度和句法通达程度的系统变化对二语加工加工可能会造成怎样的影响,同时应开展以某种语言（如汉语）的母语者其二语（如英语）句子加工认知神经机制和以前者的二语（如英语）母语者为被试开展以前者的母语（如汉语）为二语的句子加工认知神经机制的比较研究。     

Beyond Therapy and Enhancement: The Alteration of Human Nature

With the rapid progress and considerable promise of nanobiotechnology/neurosciences there is the potential of transforming the very nature of human beings and of how humans can conceive of themselves as rational animals through technological innovations. The interface between humans and machines (neuro-digital interface), can potentially alter what it means to be human, i.e., the very idea of human nature and of normal functioning will be changed. In this paper, I argue that we are potentially on the verge of a paradigm shift in terms of the ends and goals of techno-science and its applications in the biomedical sciences. In particular, the development of brain-computer interfaces could reconceptualize the very notion of what it means to be human. Hence, we should not limit our reflections of applications in terms of therapy and enhancement but also include an examination of applications aiming at the alteration of human nature. To this end I will first delineate the potential paradigm shift and then map out four distinct clusters of concerns in relation to the brain-computer interface. Finally, I argue that our moral and philosophical reflections should follow a procedural model based on managed consensus due to our pluralistic context.

The hidden persuaders break into the tired brain

There is a long-lasting debate on whether subliminal advertising actually works. In this context there are some studies suggesting that subjects’ motivation is a crucial point. Karremans et al. [Karremans, J. C., Stroebe, W., & Claus, J. (2006). Beyond Vicary’s fantasies: The impact of subliminal priming and brand choice. Journal of Experimental Social Psychology, 42, 792-798] showed that subjects were influenced in their intention to drink a specific brand of soft drink by a subliminally presented brand prime, but only if they were thirsty. In the present study, we adapted their paradigm to the concept of ‘concentration’ and embedded the subliminal presentation of a brand logo into a computer game. Actual subsequent consumption of dextrose pills (of the presented or a not presented brand) was measured dependent on the level of participants’ tiredness and the subliminally presented logo. We found the same pattern as Karremans et al. (2006): only tired participants consumed more of the subliminally presented than the not presented brand. Therefore, the findings confirm that subjects are influenced by subliminally presented stimuli if these stimuli are need-related and if subjects are in the matching motivational state.