Resilience in Scientific Research: Understanding How Natural Product Research Rebounded in an Adverse Situation

The recent declining rate in the discovery of new drugs has made natural product (NP) research—the traditional method of using living organisms to acquire drug candidates—regain its importance, despite the fact that it was once regarded as an obsolete method in the face of the exalted expectations about emerging new approaches since the 1990s. The concept of ‘resilience’ in scientific research provides a clue for understanding the dynamism of this rebound in research. Four elements may be highlighted in the context of microbial NP research in Japan: first, ‘institutional precondition’ is essential in the sense that the research must be rooted in an institutional complex involving academia, drug companies, and national policies. Second, the dual nature of the ‘attack from rival innovations’ including semiotic labeling and technical advances is examined. Third, four approaches to NP research are observed as responses to such challenges: (1) reevaluating the naturalness of NPs; (2) adopting various technical elements from their rivals; (3) shifting the emphasis from the practical pursuit of drug candidates to biological research using bioprobes; and (4) examining the uneven degree of resilience between academia and industry. Fourth and finally, NPs are viewed as an icon of cultural practice. This view may eventually open the door to questions about the meaning of ‘tradition’ in the context of general contemporary scientific research.     

The lottery of life and moral desert: An empirical investigation

As John Rawls makes clear in A Theory of Justice, there is a popular and influential strand of political thought for which brute luck – that is, being lucky (or unlucky) in the so-called “lottery of life” – ought to have no place in a theory of distributive justice. Yet the debate about luck, desert, and fairness in contemporary political philosophy has recently been rekindled by a handful of philosophers who claim that desert should play a bigger role in theories of distributive justice. In the present paper, we present the results of our attempts to fill in some of the missing empirical details of this debate. Our findings provide some preliminary evidence that, contrary to what most contemporary political philosophers have assumed, people are not as worried by natural luck as previously thought. Instead, people’s worries seem to be focused exclusively on inequalities generated by social luck.     

EXTINCTION,NATURAL EVIL,AND THE COSMIC CROSS

Did the God of the Bible create a Darwinian world in which violence and suffering (disvalue) are the means by which the good (value) is realized? This is Christopher Southgate's insightful and dramatic formulation of the theodicy problem. In addressing this problem, the Exeter theologian rightly invokes the Theology of the Cross in its second manifestation, that is, we learn from the cross of Jesus Christ that God is present to nonhuman as well as human victims of predation and extinction. God co‐suffers with creatures in their despair, abandonment, physical suffering, and death. What I will add with more force than Southgate is this: the Easter resurrection is a prolepsis of the eschatological new creation, and it is God's new creation which retroactively determines past creation. Although this does not eliminate the theodicy question, it lessens its moral sting.     

Motivating Hume's natural virtues

Many commentators propose that Hume thinks that we are not or should not be motivated to perform naturally virtuous actions from moral sentiments. I take issue with this interpretation in this paper, arguing that Hume fully incorporates the moral sentiments into his understanding of how human beings act when it comes to the natural virtues and that he does not see the moral sentiments as a problematic kind of motivation that threatens or weakens the virtuous status of the action.     

《周易》自然哲学与生命实践

《周易》蕴涵的自然哲学思想,可谓是一种以生命为隐喻,宇宙论、本体论、价值论统一的生成哲学,它基于道德实践与认识实践统一的生命实践。文章根据《周易》"经"、"传"本身之内涵,按现代哲学表述方法,从源于道德之宇宙论,三才圆通之本体论,知行不二之实践论,生成整体之方法论等方面,阐明中国式自然哲学的特性与意义。指出正是这种独特的自然哲学,不仅开启了中国文化超越的价值之源,为中国古代科学提供了形而上学基础,而且应在21世纪伟大历史转型和中西对话中,共同创造人类不同文化"殊途同归"、"和而不同"的世界生成之序。     

Conséquences d’une catastrophe naturelle touchant le lieu de travail sur l’épuisement professionnel : Le cas du personnel d’un hôpital gériatrique

The Hautmont tornado has occurred on august 03, 2008, in the North of France. It was caused major destructions in this town and particularly in this city hospital. A tornado is a major natural phenomenon that causes destructions and disasters. In the literature, natural disaster and their destructive consequences are associated with psycho-traumatic disorders, among which is posttraumatic stress. The purpose of this research was to study the psychological impact of this tornado on a particularly vulnerable population: employees of a hospital. Thirty eight employees were interviewed one year after the Tornado. The results of this study showed that this disaster had many psychological repercussions. Many cases of posttraumatic stress disorders and cases of burnout were present independently of job strain level.     

Transference and relationship: Technical Implications in the psychoanalytic process with a borderline patient

This paper reviews how the bond between the therapeutic relationship and transference is created, illustrates its technical management, and provides a basic methodology for the exploration of both transference and the therapeutic relationship. For this purpose, the current therapeutic relationship, the concept of affective dominance, the object relation triggered by transference, the past and present unconscious, and the relationship pattern (CCRT) applied to dreams will all be considered. The approach in this paper is based on an object relation conceptualization. Highlights of the theory underlying the technique will be illustrated in a succinct discussion of the clinical treatment of a borderline patient in psychoanalysis.     

Temporal stability of behavioural intention as a moderator of intention–health behaviour relationships

Seven prospective studies of health behaviours containing eight prospective datasets testing the moderating role of intention stability on intention–behaviour and past behaviour–behaviour relationships were examined within the context of the Theory of Planned Behaviour. The measure of intention stability was based on lack of change in intentions between the two measurement time points. Across different behaviours, samples and time frames more stable intentions were associated with intentions at time 1 that were stronger predictors of behaviour at time 2. Intention stability did not consistently moderate the past behaviour–behaviour relationship. Across studies the frequency-weighted mean correlation between intentions and behaviour was substantially greater for stable (r ₊?=?0.60) compared to unstable (r ₊?=?0.27) intentions (Z _difference?=?6.65, p?<?0.001). The past behaviour–behaviour correlation was also stronger for stable (r ₊?=?0.50, p?<?0.001) compared to unstable (r₊ ?=?0.34, p?<?0.001) intentions (Z _difference?=?3.12, p?<?0.01). Perceived behavioural control was the variable most strongly related to stable intentions. Implications for understanding the role of health cognitions in the performance of health behaviour are discussed.     

The theory of planned behaviour and breast self-examination: Assessing the impact of past behaviour,context stability and habit strength

This study applied the theory of planned behaviour (TPB) to the prediction of breast self-examination (BSE) intentions and behaviour, and tested whether the frequency of past behaviour and context stability moderates intention–behaviour and habit–behaviour relations. Seventy-seven females completed measures of the TPB, frequency of past behaviour, context stability and habit strength (Self-Report Habit Index). BSE behaviour was assessed at 1-month follow-up (n?=?66). The TPB explained 33% of the variance in BSE intentions and 11% of the variance in time 2 BSE. The frequency of past behaviour moderated the intention–behaviour relationship such that the intention was only positively related to time 2 BSE behaviour when the frequency of past behaviour was low. Context stability and the combination of the frequency of past behaviour?×?context stability moderated the habit–behaviour relationship such that habit strength was only positively related to time 2 BSE behaviour when context stability and the combination of frequency of past behaviour?×?context stability were high. The results are consistent with the proposal that behaviours that are performed frequently in stable contexts are predominantly under the control of habitual processes, whereas behaviours that are performed infrequently in unstable contexts are predominantly under the control of intentional processes.