Influence of intracerebroventricular administration of dopaminergic drugs on morphine state-dependent memory in the step-down passive avoidance test

The effects of dopaminergic drugs on morphine state-dependent memory of passive avoidance task were examined in mice. Pre-training administration of morphine (5mg/kg) led to state-dependent learning with impaired memory retrieval on the test day which was reversed by pre-test administration of the same dose of the opiate. The pre-test intracerebroventricular (i.c.v.) administration of the dopamine D1 receptor agonist (SKF38393), dopamine D2 receptor agonist (quinpirole) and dopamine D2 receptor antagonist (sulpiride) not only reversed the effect of pre-training morphine treatment, but also increased this action of the drug. Furthermore, the pre-test i.c.v. administration of dopamine D1 receptor antagonist (SCH23390) prevented the restoration of memory by morphine. In conclusion, the morphine-induced recovery of memory, on the test day, seems to be induced, at least in part, through dopamine receptors.     

Experience with songs in adulthood reduces song-induced gene expression in songbird auditory forebrain

Male songbirds learn to produce song within a limited phase early in life; however they continue to learn to recognize songs in adulthood. Studies looking at Zenk activation after exposure to songs learned early in life for song production and songs learned in adulthood show opposite patterns of activation, suggesting distinct neural mechanisms may be involved in these two forms of learning. In this study, we look at IEG Zenk activation in auditory regions NCM and CMM of song sparrows (Melospiza melodia) to see whether recent exposure to song in adulthood leads to greater or decreased Zenk activation upon hearing that song versus a novel song. We found significantly lower activation in birds exposed to previously heard songs versus novel songs in vNCM but not dNCM, though further analysis suggest an overall trend in NCM. We found no significant difference in the amount of activation to previously heard songs vs. novel songs in CMM. These results support previous findings suggesting that activation is reduced to learned stimuli; we discuss possible implications of these findings in relation to song production learning early in life and song recognition learning in adulthood.     

Yoga and the battlefield of ethics: Highlighting an infusion model for ethics education

This paper articulates an infusion model of ethics education for engineering students by illuminating the value of a religious studies course on yoga. This model is distinguished from four other possible approaches that have traditionally been used to prepare engineering students to face the challenges of the work place. The article is not claiming that this approach should be used to the exclusion of the other approaches, but rather that it adds strength to the other approaches. Specifically, the article claims that the infusion model provides an opportunity for students to reflect upon the foundational ethical positions emanating from the world's religions and thereby provides them with a vista from which they can not only ask what professional ethical code applies in a given situation, but also ponder the nature of character needed to follow that ethical code.     

Efficiency of visual information processing in children at-risk for dyslexia: habituation of single-trial ERPs

To investigate underlying learning mechanisms in relation to the development of dyslexia, event-related potentials to visual standards were recorded in five-year-old pre-reading children at-risk for familial dyslexia (n=24) and their controls (n=14). At the end of second grade the children aged 8 years were regrouped into three groups according to literacy level and risk factor. Single-trial analyses revealed N1 habituation in the normal-reading controls, but not in the normal-reading at-risks, and a N1 amplitude increase in the group of poor-reading at-risks and poor-reading controls. No P3 habituation was found in either group. The normal-reading at-risk group exhibited the longest N1 and P3 latencies, possibly compensating for their reduced neuronal activity during initial information extraction. In contrast, the poor-reading group only showed prolonged P3, and their increase in (initial small) N1 amplitude together with normal N1 latencies, suggests inefficient processing in an early time window, which might explain automatisation difficulties in dyslexic readers.     

An Analyst’s Experience Working In A Skilled Nursing Facility: A Case Study

With the closing of long-term psychiatric facilities, no alternative social institution has arisen to treat those persons whose chronic mental illness makes self-care impossible. This paper explores the typical paths to placement in a skilled nursing facility or nursing home and the author’s experience in working with this population using the principles and techniques of interpersonal psychoanalysis. She presents several case examples and explicates both the analyst’s and the patient’s transference. The author discusses the difficulties inherent in creating an analytic space in such a setting and working outside of the usual psychoanalytic frame.     

Vowels, syllables, and letter names: differences between young children's spelling in English and Portuguese

Young Portuguese-speaking children have been reported to produce more vowel- and syllable-oriented spellings than have English speakers. To investigate the extent and source of such differences, we analyzed children's vocabulary and found that Portuguese words have more vowel letter names and a higher vowel-consonant ratio than do English words. In a spelling experiment, we found that Portuguese speakers used more vowels, but did not produce more syllabic spellings, than did English speakers. The differences that we observed are attributable to quantitative differences in the languages and their writing and letter name systems. They do not support the widespread idea that speakers of Romance languages pass through an additional, syllabic, stage of development.     

Unconsciously Poisoning the Roots: Psychological Dynamics of the Bible in Jewish/Christian Conflict

The persistence of antisemitism in Christian cultures despite the irrationality and destructiveness of its myths and attitudes has led more than one writer to consider that it may be deeply rooted in psychological dynamics, both individual and social. Likewise, much has been written about how the New Testament writings, especially certain passages in the Gospels, reflect a bitter split between the emerging Christian community and other Jewish groups. Seldom, however, are these two avenues of exploration brought together, asking how psychological mechanisms of defense and the formation of the biblical texts interact. In a recent book, The Jew and Deicide: The Origin of an Archetype (Davis, 2003), psychologist Frederick B. Davis attempted to do just that. Unfortunately, his presentation is deeply flawed by his lack of familiarity with basic New Testament studies and methods. His fundamental premise is sound—that the interplay of the texts, the communities that created them, and their subsequent interpreters evidence psychological dynamics that fuel an ongoing conflict. In this paper, I will suggest how those dynamics were active within the first century Christian community and were expressed in New Testament writings, and how those same dynamics are stimulated in later readers.Paper originally presented March 22, 2004. In D. MacDonald (Chair), New Testament Texts and Traditions. Session conducted at the Western regional meeting of the Society of Biblical Literature, Whittier, CA     

Men’s Decision-Making About Predictive <Emphasis Type="Italic">BRCA1/2</Emphasis> Testing: The Role of Family

Men who have a family history of breast and/or ovarian cancer may be offered a predictive genetic test to determine whether or not they carry the family specific BRCA1/2 mutation. Male carriers may be at increased risk of breast and prostate cancers. Relatively little is known about at-risk men’s decision-making about BRCA1/2 testing. This qualitative study explores the influences on male patients’ genetic test decisions. Twenty-nine in-depth interviews were undertaken with both carrier and noncarrier men and immediate family members (17 male patients, 8 female partners, and 4 adult children). These explored family members’ experiences of cancer and genetic testing, decision-making about testing, family support, communication of test results within the family, risk perception and risk management. Implicit influences on men’s testing decisions such as familial obligations are examined. The extent to which other family members—partners and adult children—were involved in testing decisions is also described. It is demonstrated that mothers of potential mutation carriers not only perceive themselves as having a right to be involved in making this decision, but also were perceived by their male partners as having a legitimate role to play in decision-making. There was evidence that (adult) children were excluded from the decision-making, and some expressed resentment about this. The implications of these findings for the practice of genetic counseling are discussed.     

Subordinate male mice show long-lasting differences in spatial learning that persist when housed alone

In the wild, house mice live in social groups, whereas in the laboratory male mice are often singly housed. Environmental enrichment such as that provided by social housing has been argued to improve the cognitive performance of laboratory animals in experimental tests. The aim of the present study was to test the cost of aggressive social interactions on learning in male CD-1 mice. We found that subordinate mice from more aggressive dyads showed spatial learning impairment, measured as alternation on a T-maze. Learning impairments in subordinates have hitherto been presumed attributable to the animals' exposure to, and relative standing within, the social group. By contrast, the impairment we observed could not have been the result of recent social defeat because it persisted weeks later when the mice were housed alone. Elevated urinary corticosterone predicted later subordination, though paradoxically these abnormally high levels were reduced by pair housing.