一个中枢炎性免疫诱发长时程抑郁样行为的新模型

脂多糖(lipopolysaccharide, LPS)免疫激活模型是研究抑郁症细胞因子假说的重要动物模型, 目前国际上常用外周单次LPS注射诱发抑郁样行为, 但该模型中抑郁样行为持续仅有数小时。为建立诱发较长时程抑郁样行为的免疫激活动物模型, 本研究尝试侧脑室注射LPS激活大鼠中枢免疫炎性反应, 考察单次以及重复中枢LPS注射诱发抑郁样行为的效果, 以及中枢炎性免疫诱发行为改变的时程。结果显示：单次中枢LPS注射后24 h只能诱发旷场自发活动和探索行为下降等部分抑郁样行为, 未能诱导糖水偏好下降和悬尾不动时间增加; 3次重复注射则在末次LPS注射后24 h表现出显著的糖水偏好下降, 自发活动和探索行为减少, 悬尾不动时间增加等行为。且自发活动、探索行为减少和悬尾不动时间增加能够延续至末次LPS注射后72 h。这些结果表明脑室重复LPS注射可诱发较长时程的抑郁样行为, 这种新的中枢炎性免疫激活诱发的抑郁症模型, 为研究抑郁症炎性免疫机制提供了更为有效的动物模型, 有助于深入探讨行为和免疫功能间的复杂关系。     

视觉长时记忆激活度对促进视觉短时记忆的影响

短时记忆与长时记忆的关系是记忆领域研究的重要内容。基于此, 研究者们就视觉长时记忆是否能促进视觉短时记忆的问题展开了大量研究, 但所得出的结论并不一致。通过不同程度的学习形成不同激活度的视觉长时记忆, 考察对几何图形的视觉长时记忆是否能对变化检测中的短时记忆起到促进作用。结果发现, 低激活水平的视觉长时记忆不能促进视觉短时记忆, 而事先存在且高度激活的视觉长时记忆对视觉短时记忆却具有促进作用; 同时, 随着视觉长时记忆激活水平的提高, 刺激间间隔的效应值也逐渐减小。本研究说明, 视觉长时记忆能否促进视觉短时记忆取决于视觉长时记忆的激活水平, 高激活的视觉长时记忆对阻止视觉短时记忆痕迹的迅速消退具有重要意义。     

品牌来源国刻板印象的双重表现及其改变

研究探讨了品牌来源国刻板印象的双重表现及其改变,结果表明：从外显的层面上看,相对国外品牌,消费者普遍认为国产品牌在质量印象、传播印象上不如国外品牌,在价格印象上比国外品牌好,在服务印象和整体印象上二者无差异;相对国外品牌,消费者对国产品牌具有更为积极的内隐品牌刻板印象;以直接劝说方式激发的民族情感不能改变外显品牌来源国刻板印象,但是以间接劝说方式激发的民族情感可以使消费者对国产综合型产品的外显整体印象更为积极;无论以直接还是间接劝说方式激发的民族情感均不能使消费者对国产品牌产生更强的正向内隐品牌来源国刻板印象;品牌来源国刻板印象的激活并非完全的自动化过程。     

Behavioral inhibition and triallelic genotyping of the serotonin transporter promoter (5-HTTLPR) polymorphism

To examine the genetic bases of the behavioral inhibition system (BIS) and the behavioral approach system (BAS), we evaluated the association between the BIS, the BAS, and a functional length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) in an unscreened sample of undergraduates (N = 211); analyses were conducted using a two-variant (i.e., biallelic) genotyping and three-variant (i.e., triallelic) genotyping of the 5-HTTLPR polymorphism. People with one or two copies of the low-expressing alleles reported stronger endorsement of the BIS than people who were homozygous for the high-expressing alleles; this association was found for triallelic but not biallelic genotyping of the 5-HTTLPR polymorphism. There was no association between the 5-HTTLPR polymorphism and the BAS scales.     

Difference in Cortical Relay Time Between Intrinsic Muscles of Dominant and Nondominant Hands

The authors aimed to calculate and compare cortical relay time (CRT) between intrinsic hand muscles and between homonymous muscles of dominant and nondominant hands. The participants comprised 22 healthy volunteers. The CRT for long-latency reflexes (LLRs) was calculated by subtracting the peak latency of somatosensory evoked potentials of component N20 and the onset latency of motor evoked potentials from the onset latency of LLRs. CRT was significantly shorter for the first dorsal interosseous muscle than for the abductor pollicis brevis muscle, regardless of hand dominance. CRT for the abductor pollicis brevis muscle was significantly shorter in the dominant hand than in the nondominant hand. Evaluation of CRT for intrinsic muscles might be beneficial in the understanding of individuated finger functions.     

时间情景模型提取过程的实质初探:激活与抑制

采用扇效应技术和负启动实验范式探讨时间情景模型提取过程的实质。实验材料为18个"某人在某时间做某事"的句子,结果发现,实验条件下目标句的反应时显著长于控制条件下目标句的反应时,而两种条件下启动句的反应时无显著差异,出现了显著的负启动效应。这表明,在时间情景模型提取过程中,不仅激活了目标情景模型和与之相关的情景模型,而且对同时激活的相关的情景模型进行了抑制,支持长时记忆提取的抑制观。     

自体血清对腰背肌损伤修复作用的动物实验研究

研究自体血清局部注射对腰背肌损伤的治疗效果。建立动物模型,分组对照研究。共将实验动物分为四组,通过手术造成小鼠腰背部肌肉损伤。之后,在损伤的局部注射生理盐水,或原浓度的自体血清、二倍浓缩的自体血清、四倍浓缩的自体血清。在术后第2、4、7日分别测得各组小鼠腰背肌肌力,求四组小鼠腰背肌肌力的平均值及标准差,比较组内及组间的差异。最后,对实验结果进行了综合分析和讨论。自体血清局部注射处理的小鼠,肌力恢复更加明显,愈合后肌力明显增强,术后第7日各组肌力平均值具有显著性差异,以生理盐水注射组为对照组,原浓度血清组、二倍浓缩组、四倍浓缩组平均腰背肌力均高于对照组。动物模型验证了自体血清局部注射疗法在腰背肌损伤的动物模型中是有效的,可以促进腰背肌损伤的修复和愈合。     

害羞与进谏行为的关系:管理开放性与心理授权的调节作用

包括进谏行为在内的角色外行为研究近来广受关注。基于特质激活理论,本研究探索了害羞特质与进谏行为之间的关系,及管理开放性和心理授权对它们的调节作用。以华东地区369名企业员工为样本,采用配对成组的问卷研究,结果表明:管理开放性和心理授权均对害羞与进谏行为之间的关系存在调节效应,即当处于高管理开放性和高心理授权水平时,害羞特质与进谏行为之间的消极关系减弱,而当处于低管理开放性和低心理授权水平时,害羞特质与进谏行为之间的消极关系增强。     

Don’t stereotype, think different! Overcoming automatic stereotype activation by mindset priming

Automatic stereotype activation can be overcome intentionally and after an extensive training. However, intentions have to be tailored to a certain social category. It is hypothesized that activating the mindset “think different” by priming creativity prevents stereotypes and associations in general from becoming automatically activated. In two experiments a creative, a thoughtful or no mindset was activated. Afterwards, the activation of associations was measured using a lexical decision task with semantic priming. As predicted, the automatic activation of stereotypes (Study 1) and other associations (Study 2) was found in the control conditions but not in a creative mindset. These results suggest that people possess a mindset that allows for overcoming automatic stereotype activation without being tailored to a specific category.     

类别指称对象提取过程的发展研究

本研究选取初中二年级、高中二年级和大学二年级学生为被试,探讨了青少年对含有类别指称对象语篇心理加工过程。实验1采用命名法,实验2采用眼动记录法。结果发现,随着年级的升高,被试在单位时间内获得的信息逐渐增多,阅读能力不断提高,对类别指称概念的理解能力也不断提高;各年级被试表现出对类别指称对象激活的增强;大学生组被试还表现出对非指称对象激活的抑制;激活是立即发生的认知过程;抑制则是延缓发生的认知过程,且是一种策略性的控制加工过程。