性激素替代治疗在冠心病防治中的作用

冠心病的发病率有着明显的性别差异,大量研究表明内源性雌激素和雄激素与冠心病的发生发展有着密切关系,它对于女性和男性分别有抗动脉粥样硬化作用,这提示人们可以通过恢复机体激素水平达到防治冠心病的作用。因此性激素替代治疗成为了对冠心病的防治研究的热点,本文主要综述性激素替代治疗在冠心病防治中的研究进展。     

When saying no leads to compliance: The door-in-the-face technique for changing attitudes and behaviors towards smoking at work

IntroductionThe aim of this action research was to encourage workers to comply with an anti-smoking charter and get them to effectively reduce their tobacco use. Two change procedures were compared: a classic one based on an information campaign and an original one based on the door-in-the-face technique.MethodForty-three smoking workers participated in this study. They were assigned to one of the two groups: information campaign group or door-in-the-face group. Two types of measures were administered. The first assessed self-reported attitudes towards smoking, such as perceived dependence (Fagerström Test); the second assessed effective behavior, such as number of cigarettes smoked and physiological nicotine addiction.ConclusionTaken together, the results show that the door-in-the-face technique was more effective than the information campaign. These results are discussed in light of the social acceptability of the initial refusal.     

The multiple-stimulus-without-replacement preference assessment tool and its predictive validity

This study demonstrates the use of two web-based programs, one to identify video preferences and the other to assess their reinforcing effects. We used the Multiple-Stimulus-Without-Replacement Preference Assessment Tool (MSWO PAT) to identify the video preference hierarchies of seven participants, ages 4–11 years old. We then used a customized reinforcer assessment program that arranged a concurrent-chains preparation with programmed conjugate schedules of reinforcement. Button presses emitted by participants modulated the quality (volume and opacity) of selected videos on a moment-to-moment basis, allowing us to identify the reinforcing effects of the videos in little time. The results showed that the preference assessment had predictive value for five of seven participants. We discuss the MSWO PAT, parameters that may affect the identification of preferences and the use of conjugate schedules to identify reinforcers.     

Addictive Personality Factors

This study was designed to compare mean scores obtained by alcoholics, compulsive gamblers, smokers, chronic joggers, and control subjects on six subfactors of the MacAndrew Alcoholism Scale. Results indicated that some MacAndrew factors may be more sensitive to addictive pathology than others. Alcoholics emerged as the most pathological group, in terms of scores on the Cognitive Impairment, Social Maladjustment, and Risk Taking scales. Gamblers and smokers appeared to be distinctly different, more socially oriented addicts. Frequency of jogging was negatively related to measures of addiction but positively related to measures of compulsiveness.     

The End of the Solidly Democratic South: The Impressionable‐Years Hypothesis

The partisan realignment of the White South, which transformed this region from being solidly Democratic to being the base of the Republican Party, has been the focus of much scholarship. Exactly how it occurred is unclear. Widespread individual‐level attitude changes would be contrary to the well‐known within‐person stability of party identification. However, according to the impressionable‐years hypothesis, events that occur during adolescence and early adulthood may have a lasting impact on later political attitudes. This would suggest that cohort replacement may be driving partisan realignment. We test this possibility using data from the American National Election Studies from 1960 to 2008. Consistent with the impressionable‐years hypothesis, Southern Whites from the pre‐Civil Rights cohort (born before 1936) maintained their Democratic Party identification longer than their younger counterparts. However, all cohorts in the South have changed their partisan attitudes at comparable rates over time, contrary to the impressionable‐years hypothesis. These data suggest that the partisan realignment of the South was driven by both cohort replacement and within‐cohort attitude change. More targeted case studies of older cohorts living through the civil rights era, and of younger cohorts in the post‐Reagan era, yield results generally consistent with the impressionable‐years hypothesis. More generally, our findings suggest that very large scale events are required to disrupt the normal continuity of party identification across the life span.     

读写分离的脑神经机制：来自fMRI的证据

使用只读不写的繁体字和会读会写的简体字材料, 以默读为实验任务, 探讨“会读会写”与“只读不写”文字的加工脑区。8名在校大学生在磁共振扫描过程中默读呈现的繁体字或简体字, 采用ANOVA统计全脑激活图。与简体字相比, 繁体字额外激活了右额下回、左小脑。在功能连接性上, 简体字和繁体字相同的激活脑区有左楔前叶-左内侧前额叶, 左楔前叶-左中央前回, 右枕中回-左舌回; 不同的是, 繁体字左楔前叶与右额下回有高相关, 而简体字左楔前叶与右额中回有高相关。左内侧前额叶与中央前回只在繁体字中表现出高相关。繁体字和简体字任务的T检验差异脑区包括左颞中回和右顶下小叶。只读不写的文字具有加工的整体性和轮廓性特征, 它的读音与不规则简体字相似, 具有整字加工特点。繁体字和简体字加工具有相同的功能连接区, 但也存在差异。右脑表现为连接脑区不同, 左脑内侧前额叶与中央前回表现为相关性不同, 说明内侧前额叶-中央前回在繁体字加工中起着重要作用。实验结果还证明顶叶是记忆再认的主要脑区。     

从雌激素替代治疗的历史看临床决策的影响因素

20世纪40年代,动物实验提供的致癌效应证据限制了雌激素替代治疗的应用。20世纪60年代,价值观因素极大地推动了雌激素替代治疗,以至于关于致癌效应的证据被忽视。20世纪70年代,人群研究提供的致癌效应证据使得雌激素替代治疗的应用不断减少。20世纪80年代,致癌效应的消除和观察性流行病学研究提供的心脏保护证据,将雌激素替代治疗的应用推向了顶峰。20世纪末,大规模随机对照试验提供的有害效应证据推动了雌激素替代治疗应用的大幅下降。雌激素替代治疗一波三折的历史体现了证据、价值观在不同时期对临床决策的不同影响,说明只有遵循循证医学的实践模式,基于现有最佳的科学证据,并结合医生的临床经验与患者的价值观,才可能做出科学、有效的临床治疗决策。     

学习不良儿童心理健康的特点研究

考察学习不良儿童心理健康（学习、自我、人际关系、社会生活适应）的特点。被试为小学3～5年级83名儿童。结果发现：学习不良儿童与一般儿童的心理健康存在显著差异;学习不良儿童的学习、自我、社会生活适应等方面显著低于一般儿童。在学习各维度上,学习不良儿童与一般儿童的自我满足感、体脑协调性、学习习惯之间存在显著差异;在自我各维度上,学习不良儿童与一般儿童的社会自我、学术自我、自我认同之间存在显著差异;在社会生活适应各维度上,学习不良儿童与一般儿童的亲社会行为、居家能力存在显著差异。     

减少医师自卫医学行为的对策研究

根据自卫医学行为产生的原因,减少自卫医学行为有两个思路,一个是减轻医师的法律责任,另一个是化解医师在法律责任下所面临的风险.根据第二个思路,应该采取下面的措施:建立医师责任保险制度;建立医疗责任保险制度;实施医疗风险管理;提高医师个人的执业素养.     

A Steppenwolf called Brian: Reflections on childhood suffering and creativity

Through the life of the writer Brian Aldiss, this paper explores the idea that if parents are unable to give a child a solid sense of self, the child may grow up with a burning need to find that self through artistic creation. One not uncommon reason for this failure is if the child is a replacement for another child who has died and the parents have not been able to do the grief work required in mourning. This task is often more problematic in the case of a stillbirth. Examples are given of other creative people, such as Freud and Dali, where a previous death in the family may have been the spur to their finding a special identity through their creativity.