Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors

Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD). However, there is little knowledge about the effects of the interaction on distinct symptom clusters of PTSD. This study aimed to investigate the relation between the interaction of 5-HTTLPR and earthquake-related exposures and a contemporary phenotypic model of DSM-5 PTSD symptoms in a traumatised adult sample from China.

Design: A cross-sectional design with gene-environment interaction (G?×?E) approach was adopted. Methods: Participants were 1131 survivors who experienced 2008 Wenchuan earthquake. PTSD symptoms were assessed with the PTSD Checklist for DSM-5 (PCL-5). The 5-HTTLPR polymorphism was genotyped with capillary electrophoresis (CE) in ABI 3730xl genetic Analyzer.

Results: Although there was no significant interaction between 5-HTTLPR and traumatic exposure on total PTSD symptoms, respondents with the LL genotype of 5-HTTLPR who were highly exposed to the earthquake experienced lower intrusion and avoidance symptoms than those with the S-allele carriers.

Conclusions: The findings suggest that the 5-HTTLPR may have an important impact on the development of PTSD and add to the extant knowledge on understanding and treating of posttraumatic psychopathology.     

Profile Analysis of Psychological Symptoms Associated With Misophonia: A Community Sample

Misophonia is characterized by extreme aversive reactions to certain classes of sounds. It has recently been recognized as a condition associated with significant disability. Research has begun to evaluate psychopathological correlates of misophonia. This study sought to identify profiles of psychopathology that characterize misophonia in a large community sample. A total of N = 628 adult participants completed a battery of measures assessing anxiety and anxiety sensitivity, depression, stress responses, anger, dissociative experiences, obsessive-compulsive symptoms and beliefs, distress tolerance, bodily perceptions, as well as misophonia severity. Profile Analysis via Multidimensional Scaling (PAMS) was employed to evaluate profiles associated with elevated misophonia and those without symptoms. Three profiles were extracted. The first two accounted for 70% total variance and did not show distinctions between groups. The third profile accounted for 11% total variance, and showed that misophonia is associated with lower obsessive-compulsive symptoms for neutralizing, obsessions generally, and washing compared to those not endorsing misophonia, and higher levels of obsessive-compulsive symptoms associated with ordering and harm avoidance. This third profile extracted also showed significant differences between those with and without misophonia on the scale assessing physical concerns (that is, sensitivity to interoceptive sensations) as assessed with the ASI-3. Further research is called for involving diagnostic interviewing and experimental methods to clarify these putative mechanisms associated with misophonia.     

Investigating Individual Differences in Toddler Search with Mixture Models

Children's performance on cognitive tasks is often described in categorical terms in that a child is described as either passing or failing a test, or knowing or not knowing some concept. We used binomial mixture models to determine whether individual children could be classified as passing or failing two search tasks, the DeLoache model room task and the Berthier et al. door task. The data support categorical classification of the children and suggest that the increase in average proportion correct with age is the result of an increasing proportion of children who can solve the tasks. Performance on the two tasks was concordant, and improving performance could be due to advances in a single psychological ability, such as cognitive control. Copyright © 2014 John Wiley & Sons, Ltd.     

Thinking bigger: The Cronbachian paradigm & personality theory integration

Personality theories largely mirror disparities between fundamental paradigms that guide most psychology: one based upon Galton’s emphasis on inter-individual differences and the lexical hypothesis; the other inspired by Wundt is focused upon intra-individual processes, such as temperament and Reinforcement Sensitivity Theory. Previous integrations of personality models using these paradigms failed to account for observed variance, suggesting model incommensurability. We propose that a broader conception—developed from Cronbach and colleagues’ generalisability theory—provides an effective integrating framework, and show how Galtonian and Wundtian models may be assimilated within Cronbachian approaches. Additionally, Cronbachian models have novel practical implications. Application of the Cronbachian paradigm to personality will be challenging, but provides an opportunity to achieve genuine coherence in personality research.     

Identifying expectations about the strength of causal relationships

When we try to identify causal relationships, how strong do we expect that relationship to be? Bayesian models of causal induction rely on assumptions regarding people’s a priori beliefs about causal systems, with recent research focusing on people’s expectations about the strength of causes. These expectations are expressed in terms of prior probability distributions. While proposals about the form of such prior distributions have been made previously, many different distributions are possible, making it difficult to test such proposals exhaustively. In Experiment 1 we used iterated learning—a method in which participants make inferences about data generated based on their own responses in previous trials—to estimate participants’ prior beliefs about the strengths of causes. This method produced estimated prior distributions that were quite different from those previously proposed in the literature. Experiment 2 collected a large set of human judgments on the strength of causal relationships to be used as a benchmark for evaluating different models, using stimuli that cover a wider and more systematic set of contingencies than previous research. Using these judgments, we evaluated the predictions of various Bayesian models. The Bayesian model with priors estimated via iterated learning compared favorably against the others. Experiment 3 estimated participants’ prior beliefs concerning different causal systems, revealing key similarities in their expectations across diverse scenarios.     

Fitting direct covariance structures by the MSTRUCT modeling language of the CALIS procedure

This paper demonstrates the usefulness and flexibility of the general structural equation modelling (SEM) approach to fitting direct covariance patterns or structures (as opposed to fitting implied covariance structures from functional relationships among variables). In particular, the MSTRUCT modelling language (or syntax) of the CALIS procedure (SAS/STAT version 9.22 or later: SAS Institute, 2010) is used to illustrate the SEM approach. The MSTRUCT modelling language supports a direct covariance pattern specification of each covariance element. It also supports the input of additional independent and dependent parameters. Model tests, fit statistics, estimates, and their standard errors are then produced under the general SEM framework. By using numerical and computational examples, the following tests of basic covariance patterns are illustrated: sphericity, compound symmetry, and multiple‐group covariance patterns. Specification and testing of two complex correlation structures, the circumplex pattern and the composite direct product models with or without composite errors and scales, are also illustrated by the MSTRUCT syntax. It is concluded that the SEM approach offers a general and flexible modelling of direct covariance and correlation patterns. In conjunction with the use of SAS macros, the MSTRUCT syntax provides an easy‐to‐use interface for specifying and fitting complex covariance and correlation structures, even when the number of variables or parameters becomes large.     

A general proof of consistency of heuristic classification for cognitive diagnosis models

The Asymptotic Classification Theory of Cognitive Diagnosis (Chiu et al., 2009, Psychometrika, 74, 633–665) determined the conditions that cognitive diagnosis models must satisfy so that the correct assignment of examinees to proficiency classes is guaranteed when non‐parametric classification methods are used. These conditions have only been proven for the Deterministic Input Noisy Output AND gate model. For other cognitive diagnosis models, no theoretical legitimization exists for using non‐parametric classification techniques for assigning examinees to proficiency classes. The specific statistical properties of different cognitive diagnosis models require tailored proofs of the conditions of the Asymptotic Classification Theory of Cognitive Diagnosis for each individual model – a tedious undertaking in light of the numerous models presented in the literature. In this paper a different way is presented to address this task. The unified mathematical framework of general cognitive diagnosis models is used as a theoretical basis for a general proof that under mild regularity conditions any cognitive diagnosis model is covered by the Asymptotic Classification Theory of Cognitive Diagnosis.