GIRK1在宫颈癌组织细胞中的表达

探求内向整流型钾离子通道1（GIRK1）与宫颈癌发生发展的关系.利用RT-PCR及免疫组织化学技术检测GIRK1 mRNA及蛋白在15例正常宫颈和30例宫颈癌组织细胞中的表达.GIRK1 mRNA在宫颈癌组织中的表达高于在正常宫颈组织中的表达,差异有统计学意义（P〈0.01）;GIRK1蛋白在宫颈癌组织中的阳性表达率为100%,在正常宫颈组织中的阳性表达率为20%,两者差异有统计学意义（P〈0.01）.GIRK1 mRNA及蛋白在宫颈癌组织中呈高表达,可能与宫颈癌的发生及发展有关.     

整合临床医学的必要性、可行性及途径——以睡眠呼吸暂停防控为例

长期以来以专科划分为主的医疗发展方式确实促进了现代医学的进步.然而,人是一个整体不应该被割裂对待.所以,这种医学发展趋势应该加以控制,否则必然会阻碍医学事业的健康发展.另外,如果只关注局部治疗想要取得突破已经越来越难.因此,整合临床医学势在必行.本文分别从阻塞性睡眠呼吸暂停的病因、临床表现(包括合并症)及诊断和治疗三个方面阐述了只有全面进行医学整合才能提高阻塞性睡眠呼吸暂停的整体防控水平.     

Evidence Supporting the Importance of Peripheral Visual Information for the Directional Control of Aiming Movement

The focus of the present study was on determining whether the high level of directional accuracy found in aiming studies in which the subjects can see their hand in the visual periphery supports the existence of a kinetic visual channel or, rather, the advantage of binocular over monocular vision for movement directional control. The limits of this kinetic visual channel were also explored. The results of the 1st experiment indicated that seeing one's hand in the visual periphery is sufficient to ensure optimal directional aiming accuracy. Further, no differences in aiming accuracy were noted between monocular and binocular vision. These results supported the existence of a visual kinetic channel. In the 2nd experiment, whether this kinetic visual channel would operate with movements slower (55°/s) than those usually used in studies that had proved its existence (over 110°/s) was determined. The results indicated that this visual kinetic channel was operative even at relatively slow movement velocities. Central vision of the hand seemed to be used for on-line directional control of relatively slow movements.     

Relationships Between Attachment Security and Self-Construal Orientations

The authors report the results of two studies in which they explored the relationship of related and individuated self-construals, as suggested by the balanced integration—differentiation (BID) model (E. O. Imamo?lu, 2003), with (a) general attachment security in the first study (N = 168 Turkish university students) and (b) relationshipspecific attachment security with the family, peers, and romantic partners in the second study (N = 110 Turkish university students). Results indicated that attachment security tended to be associated with the relational self-orientation; however, when relatedness was complemented with individuation, there was a trend toward enhanced attachment security that reached significance when multiple measures of attachment across relationship contexts were considered. The authors discuss results with reference to their implications for attachment theory and the BID model.     

The Development of a Simple Ballistic Skill with and Without Visual Control

80 randomly selected male Ss discriminated the “effort” required to perform a simple 1-handed ballistic aiming task: aligning a Fletcher’s Trolley with a pointer placed at varying distances adjacent to an inclined wooden track. Groups were aged 5-6, 10-11, 15-16, and 18 or more yr., with 10 Ss able to see both hands and target while the other 10 could see neither. A split-plot factorial design was used. On excluding the 5-6 yr.-old “Nonvision” children, the remaining 7 sub-groups were shown to be homogeneous. Mean absolute error scores increased with Distance, and also with a decrease in Age. In the “Non-vision” condition accuracy was reduced still further for all Ss. Age, Vision, and Distance and the interaction of Age with Vision were all significant, p<.01.     

Work and Rest Variables in the Acquisition of Psychomotor Tracking Skill

College students (75 men, 75 women) matched in preliminary performance of 100 sec on the rotary pursuit apparatus were randomly assigned to five experimental groups. Their work/rest ratios, measured in seconds, were: 20/20, 30/30, 60/60, 90/90,120/120. All subjects received 30 min of total practice time after the matching trial. There was a significant practice effect and a significant practice x conditions interaction, but no main effect due to the cycles’ length or number. The decay rate of reactive inhibition (lr) is probably independent of its prior growth level; hence postrest residual lr is proportional to prerest accumulation. Partly because they generated lr in hypothetically greater amounts, women were significantly less proficient on the average than men, and sex interacted with practice. Although males had higher initial and final levels of ability than females, the two sexes’ acquisition curves showed the same rate parameters in our mathematical model.     

The conceptual distinction between projective identification (Klein) and container-contained (Bion)

This paper describes the use of play in the psychotherapy of a latency child from a severely traumatised background. It considers the meaning of play in relation to the role of the psychotherapist and to psychotherapeutic technique and explores its functions in terms of the child's development. The paper documents the psychotherapist's learning experience about the difficulty of trying to make the ‘right’ interpretations and her consequent realisation of the intrinsic value of play in psychotherapy. In considering these themes, the author explores how, by placing interpretation secondary to play, the therapy enabled the development of the child's creativity and self-agency, facilitating a movement from primarily paranoid–schizoid defences towards the beginnings of a depressive position.     

A Guide to Women in Management

The majority of occupational therapists are female clinicians who tend to be motivated by human service. They do not tend to be motivated by administrative or managerial responsibilities beyond those essential to local disciplines functions. More occupational therapists may become interested in management once they are aware of sociocultural assumptions and prejudices as well as the specific qualifications and competencies involved. Sex role stereotyping and some roles are reviewed. Assertiveness training and basic management competencies are listed as pertinent skill acquisitions.     

Perceptual Integration of Timing and Intensity Variations in the Perception of Musical Accents

The author investigated the detection of timing and intensity variations in tone sequences within the framework of perceptual independence or integration. The participants listened to sequences of tones that contained variations in timing, intensity, or both. Each participant tried to detect variations in the dimension that was declared relevant, which was either timing or intensity. The irrelevant dimension was held constant, or varied in a manner uncorrelated with the relevant dimension, or varied in a correlated manner. When the variations in the 2 dimensions were correlated, the correlation could be either positive (i.e., timing and intensity created accents in the same sequences) or negative (i.e., timing and intensity created accents in different sequences). Uncorrelated variation in the irrelevant dimension interfered with the detection of variations in the relevant dimension. In the case of a positive correlation between the 2 dimensions, the detection of variations was better than it was with the absence of variation in the irrelevant dimension only for participants who attended to timing. In the case of a negative correlation, the effect was the opposite. The results showed that timing and intensity accents were not processed by completely independent channels. Rather, information from the 2 dimensions combined at a late stage of processing.     

Psychodynamic counsellor training integrating difference

Abstract

Psychodynamic counselling has been criticized for being inflexible, authoritarian, antiquated and unresponsive to the issues of modern-day society. Psychodynamic counsellor training is sometimes seen as a poor relation of ‘proper’ psychotherapy therapy training. This article is written by two psychodynamic counselling course trainers who have wresded with the above criticisms and who have striven to deliver a training course that is coherent in its adherence to a psychodynamic counselling model but which embraces equal opportunities issues and takes account of a diverse society. The article focuses on ways in which sexual identity, race and culture are integrated into the course curriculum and indeed into the course philosophy and community. Traditional psychoanalytic interpretations of homosexuality are challenged and multicultural counselling ideas are merged with psychodynamic counselling theory and skills.