脂多糖激活所致大鼠抑郁样行为及对海马神经细胞钾电流变化的影响

采用细胞因子刺激剂脂多糖(lipopolysaccharide, LPS)为免疫激活手段, 研究LPS诱导的免疫激活产生的抑郁样行为及对海马神经细胞电压依赖钾电流变化的影响。应用膜片钳技术对海马神经细胞钾电流进行全细胞记录, 比较抑郁样行为大鼠与正常大鼠钾离子通道电流密度和激活特性的变化。结果发现, 与生理盐水对照组相比, 一次LPS注射后2 hr, 实验组动物产生抑郁样行为, 同时急性观察的海马神经细胞的钾离子通道的电流密度呈现显著升高(p<0.01); 而一次LPS注射后24 hr, 动物的抑郁样行为消失, 且急性观察的海马神经细胞的钾离子通道与对照组相比较, 其电流密度和激活曲线没有显著性变化。结论：LPS诱导的抑郁样行为, 与LPS诱导的海马神经细胞电压依赖钾电流的上调在时程上同步, 提示钾离子通道可能参与免疫激活所致的抑郁样行为。     

多感觉整合测量范式中存在的影响因素探讨

已有的多感觉整合研究范式多采用不同单通道刺激和双通道刺激随机呈现的方式进行测量。在这种范式中混有通道转换效应, 该效应可能导致多感觉整合的测量结果不准确。因此, 分析清楚实验范式中通道转换效应的影响因素, 并以此为依据设计合理的整合测量范式, 是进行多感觉整合研究的一个必要前提。本文首先通过实验一验证了在经典的整合测量范式中通道转换效应的影响方式; 进而, 在实验二中通过控制前后刺激的信号强度的一致性, 分析了通道转换效应的特点。综合分析显示, 通道转换效应是由前一刺激差异所造成的对当前刺激通道加工的注意资源分配和警觉水平的变化所导致。该结果表明, 在多感觉行为测量中, 需先根据前一刺激通道分类后再进行分析。     

Researching psychotherapy integration: A heuristic approach

Moustakas argues that questions and methodology in heuristic research flow out of inner awareness, meaning and inspiration. The approach might arguably embrace a combination of qualitative research methods, and constitute a kind of bricolage. This paper describes a heuristic enquiry into psychotherapy integration that used such a combination of methods – an interpretative phenomenological approach, case studies, reflexive action, and writing. It demonstrates how each of these methods contributed to the six phases of heuristic enquiry, from the initial engagement with psychotherapy as a trainee to the creative synthesis of published works and a PhD thesis, together with some reflection on the enquiry's limitations and rigour. Published texts, training, clinical practice and reflexivity constituted the material from which a new organizing framework for understanding psychotherapy integration was formulated. The author reflects on how the research design allowed deep engagement with this material, and changed his perspective of psychotherapy integration. In conclusion, this paper suggests that both psychotherapy integration and heuristic enquiry can only be conducted on an individual and personal basis, and that it is the quality of the relationship, with the client, or the research material, that produces results.     

走出中西医结合模式的误区

中西医汇通的实质是站在中医的立场理解西医、解释西医、评价西医;目前的中西医结合模式则是站在西医及西方自然科学的立场理解中医、解释中医、评价中医。从表面看,目前的中西医结合与中西医汇通思路相反,但从深层看,两者并无本质区别。目前的中西医结合模式与当年的中西医汇通一样是行不通的。     

南北朝象数易学发展特点述略

南朝郑、王易学并立,北朝象数易学占主导,但后期也呈现儒玄并融的趋势．《易传《》和汉代易学创造出来的象数成果得到南北朝易学家的继承,南朝易学家对象数易学中的形式主义学风给予了批判,并呈现出本体论思维与易学象数相结合的思想萌芽．象数易学受到佛教缘起性空理论的批判,但南北朝佛教仍利用易学象数来说明现象世界．在南北朝道教养生理论中,象数易学得到了丰富和发展．在南北朝的宗教风气下,象数易学占验派沦为方伎．     

从个体主义到文化主义--心理学研究范式的转向与整合

西方心理学存在两种不同的研究范式,即个体主义和文化主义。文章拟以库恩的“范式”为标准,阐述西方心理学个体主义范式到文化主义范式的演变,剖析二者的基本观点及其优势和局限。在此基础上提出两者整合的构思。     

Audiotactile multisensory interactions in human information processing

Abstract:  The last few years has seen a very rapid growth of interest in how signals from different sensory modalities are integrated in the brain to form the unified percepts that fill our daily lives. Research on multisensory interactions between vision, touch, and proprioception has revealed the existence of multisensory spatial representations that code the location of external events relative to our own bodies. In this review, we highlight recent converging evidence from both human and animal studies that has revealed that spatially-modulated multisensory interactions also occur between hearing and touch, especially in the space immediately surrounding the head. These spatial audiotactile interactions for stimuli presented close to the head can affect not only the spatial aspects of perception, but also various other non-spatial aspects of audiotactile information processing. Finally, we highlight some of the most important questions for future research in this area.     

Know thy sound: Perceiving self and others in musical contexts

This review article provides a summary of the findings from empirical studies that investigated recognition of an action's agent by using music and/or other auditory information. Embodied cognition accounts ground higher cognitive functions in lower level sensorimotor functioning. Action simulation, the recruitment of an observer's motor system and its neural substrates when observing actions, has been proposed to be particularly potent for actions that are self-produced. This review examines evidence for such claims from the music domain. It covers studies in which trained or untrained individuals generated and/or perceived (musical) sounds, and were subsequently asked to identify who was the author of the sounds (e.g., the self or another individual) in immediate (online) or delayed (offline) research designs. The review is structured according to the complexity of auditory–motor information available and includes sections on: 1) simple auditory information (e.g., clapping, piano, drum sounds), 2) complex instrumental sound sequences (e.g., piano/organ performances), and 3) musical information embedded within audiovisual performance contexts, when action sequences are both viewed as movements and/or listened to in synchrony with sounds (e.g., conductors' gestures, dance). This work has proven to be informative in unraveling the links between perceptual–motor processes, supporting embodied accounts of human cognition that address action observation. The reported findings are examined in relation to cues that contribute to agency judgments, and their implications for research concerning action understanding and applied musical practice.     

Rational Actions and the Integration of Knowledge

Summary  The paper emphasizes the role of knowledge dimensions of an action which could be regarded as rational. Rational action usually results of specific decision – making process including selection, evaluation and acceptance of a preferred alternative. This process should integrate not only various types of knowledge but also the interdisciplinary or interdepartmental knowledge integration. The integration of knowledge may cover various forms, especially integration of knowledge relating to different domains, of different quality, of knowledge connected with different goal-orientations. The paper stresses the role of the hitherto known and recognized alternatives. The integration procedures should also include the integration of various spheres and types of knowledge with accepted and justified systems of values.