克服肿瘤干细胞耐药性的策略和思路

肿瘤干细胞（cancersterncells,CSCs）是肿瘤细胞的祖细胞。已有的研究表明,肿瘤干细胞对多种化疗药物具有耐药性,是导致肿瘤治疗后复发的根源。研究针对肿瘤干细胞的治疗方法,克服肿瘤干细胞耐药性,将给肿瘤治疗模式带来全新的改变,有望彻底改善肿瘤患者的预后。     

冠脉介入治疗时期氯吡格雷抵抗的认识与思考——抓住本质，全面获益

急性冠脉综合征已步入药物洗脱支架进行血运重建的时期,双联抗血小板治疗是接受PCI治疗的常规手段。临床发现部分患者不能从氯吡格雷治疗中获益,存在氯吡格雷抵抗的现象。笔者就氯吡格雷抵抗的发生机制、临床意义及治疗对策进行描述,反映相关研究的趋势和方向,为未来更优化抗血小板治疗提出一种策略。     

Within-subject testing of the signaled-reinforcement effect on operant responding as measured by response rate and resistance to change

Response rates under random-interval schedules are lower when a brief (500 ms) signal accompanies reinforcement than when there is no signal. The present study examined this signaled-reinforcement effect and its relation to resistance to change. In Experiment 1, rats responded on a multiple random-interval 60-s random-interval 60-s schedule, with signaled reinforcement in only one component. Response resistance to alternative reinforcement, prefeeding, and extinction was compared between these components. Lower response rates, and greater resistance to change, occurred in the component with the reinforcement signal. In Experiment 2, response rates and resistance to change were compared after training on a multiple random-interval 60-s random-interval 60-s schedule in which reinforcer delivery was unsignaled in one component and a response-produced uncorrelated stimulus was presented in the other component. Higher response rates and greater resistance to change occurred with the uncorrelated stimulus. These results highlight the significance of considering the effects of an uncorrelated signal when used as a control condition, and challenge accounts of resistance to change that depend solely on reinforcer rate.     

Employee Cynicism and Resistance to Organizational Change

We offer a reconceptualization of employee cynicism and present the results of two studies to test the hypotheses that (a) cynicism about an organizational change is distinguishable from skepticism about the change, more general forms of cynicism (disposition and management), and trust in management, (b) change-specific cynicism and skepticism relate differently to personal and situational antecedent variables, and (c) change-specific cynicism accounts for variance in employees intention to resist change not explained by skepticism, trust, and more general forms of cynicism. Study 1 was conducted with employees (N=65) from several organizations undergoing various changes, and Study 2 with employees (N=701) from a single organization undergoing restructuring and culture change. Results were generally consistent with prediction. Implications for future research and for the management of change are discussed.     

Analyzing Thorndike's Law Of Effect: The Question Of Stimulus-response Bonds

The stimulus—response bond postulated by Thorndike's (1911) law of effect is not required in a functional account of behavior in relation to its consequences. Moreover, the notion of a bond has been challenged by the findings of several experiments. Nevertheless, it remains viable in the light of reanalyses of those findings. Thorndike's suggestion that the strength of the bond depends on the magnitude of satisfaction is consistent with current research on resistance to change.     

Why Don't Continents Move? Why Don't People Change?

People don't change because they can't, don't want to, don't know how, or don't know what to change. The transtheoretical model provides an integ-rative model for understanding reasons for not changing, as well as readiness to change. Stages and levels of change guide therapists in their work in helping clients change. Clients in the precontemplative stage typically cannot change without special help. Those in the contemplation stage are not sure they want to change. Those in the preparation stage are afraid they do not know how to successfully change. The levels of change help guide therapists and clients on what to change.     

Assuming a Position: Women and Men as Moral Critics in Their Own War Zone

In their search for an authentic moral self, women and men may at some time in their lives assume a position of resistance. Men are most likely to assume this position in the sphere of war. It is not clear, however, where or when women would be expected to assume such a position or what the nature of that position might be, and how far it could be likened to that of the resisting man. This paper explores the idea that choosing to be a single mother can be a position by and from which women can voice their moral criticism. Such position is comparable to the (known and well-studied) position taken by men who show their moral criticism by refusing to participate in a specific battle during a morally controversial war. The paper begins with an examination of the philosophical and psychological concepts of separate and connected moral positions available to resisting men and women in the spheres of war and family. The conclusions are based on data from two samples of resisters in the spheres of war and the family: 36 soldiers (30 years old on average) who decided to take a stand as selective conscientious objectors (SCOs) during a morally controversial war and 50 (biologically) mature single women (over age 30) who chose to become pregnant and to remain unwed mothers. The conceptual and methodological questions regarding this comparison are discussed.     

Religious Ethics and the Spirit of Undomesticated Dissent

The field of religious ethics contributes to practices of resistance and hope in broader society. In advancing my claim that religious ethics contributes to practices of resistance and hope today, I first tell a story about the changing demographics in the field of religious ethics and why this demographic shift is important. I next focus on womanist religious scholarship as an exemplary discourse in religious ethics and how it has contributed to practices of resistance and hope in the academy and within contemporary society. While a few scholars in JRE over the last 50 years have cited and engaged womanist ethicists like Katie Cannon and Emilie Townes, I want to offer a more explicit argument on how the womanist idea has contributed to practices of resistance and hope. I maintain that womanist religious scholarship embodies the practice of undomesticated dissent and that such dissent might be understood as a contribution to larger humanistic inquiry within the academy. Finally, I briefly consider an objection to my argument through engaging Stanley Fish's claim that the purposes and ends of institutions of higher education should not be oriented toward activism.     

Juggling Multiple Roles and the Act of Resistance

This article addresses some ways mothers cope with the multiple stresses associated with their dual roles as workers and primary family caregivers. During the often stressful family life-cycle when adolescent children are individuating, a mother's active resistance can call attention to her need for support and validation of her efforts. While both parents are in the process of negotiating the intricate balance between letting go and forming new collaborative relationships with their soon to be adult children, heavy responsibilities associated with the maternal role can be especially challenging. In addition to gender-sensitive family interventions, mutual support groups for women who parent can help explore ways to effectively respond to cross-generational conflicts and problem solving.     

Parent as Saboteur in the Therapeutic Treatment of Children

Children present some unique challenges to the therapist regarding treatment. Unlike adult patients, they are obviously still dependent upon the parent for transportation, the payment of fees, and the success or failure of treatment. Thus the parents make the ultimate decision to continue or terminate treatment. But sometimes a parent's characterological problems are activated by their child's treatment. These diagnostic problems can be classified as envy, jealousy, competition, and narcissism. When any or all of these unresolved parental issues are touched by the treatment of their child, some parents become determined to sabotage therapy, despite the necessity of the treatment for their child. The author's intent is to identify the parental characterological issues for sabotaging therapy through both a theoretical analysis and a discussion of the particular methods parents employ to achieve this end. Identification of the various strategies for handling hostile parents and elaboration of various methods that the therapist may employ are discussed when parental sabotaging of treatment becomes a problem. Recommendations for particular interventions are suggested to illuminate the challenges the therapist faces with those parents whose intent is to sabotage treatment.