Impaired awareness of movement disorders in Parkinson’s disease

Background

This study analyzed the presence of awareness of movement disorders (dyskinesias and hypokinesias) in 25 patients with Parkinson’s disease (PD) and motor fluctuations (dyskinesias, wearing off, on–off fluctuations). Of the few studies that have dealt with this topic, none have analyzed the differences in the awareness of motor deficits by comparing the on and off states using motor scales and an extensive battery of tests to assess cognitive and behavioral functioning.

Methods

PD patients were compared on three different scales that we have devised to measure awareness of movement disorders: Global Awareness of Movement (GAM) Disorders, dyskinesia/hypo-bradykinesia rating scales.

Results

Data showed that PD patients had greater awareness and psychological suffering in the off state than in the on state. In particular, they were troubled by motor disabilities related to hypokinesias and had mood-related symptoms and a perception of disability in activities of daily living. Interestingly, patients only showed a selective reduction of awareness of movement disorders associated with executive functions and related to dyskinesias in the on state, compared to a preserved awareness of hypokinesias in the off state. On the contrary, no association with executive functions was found in the off state.

Conclusion

Our findings suggest that the dopaminergic overstimulation of mesocorticolimbic pathways may cause a dysfunction of prefrontal–subcortical connections related to the impaired insight.     

Fitts’ law holds for pointing movements under conditions of restricted visual feedback

Fitts’ law robustly predicts the time required to move rapidly to a target. However, it is unclear whether Fitts’ law holds for visually guided actions under visually restricted conditions. We tested whether Fitts’ law applies under various conditions of visual restriction and compared pointing movements in each condition. Ten healthy participants performed four pointing movement tasks under different visual feedback conditions, including full-vision (FV), no-hand-movement (NM), no-target-location (NT), and no-vision (NV) feedback conditions. The movement times (MTs) for each task exhibited highly linear relationships with the index of difficulty (r² > .96). These findings suggest that pointing movements follow Fitts’ law even when visual feedback is restricted or absent. However, the MTs and accuracy of pointing movements decreased for difficult tasks involving visual restriction.     

The influence of a long term exercise program on lower limb movement variability and walking performance in patients with peripheral arterial disease

The purpose of this study was to examine the effects of a 12 month exercise program on lower limb movement variability in patients with peripheral arterial disease (PAD). Participants (n = 21) with an appropriate history of PAD and intermittent claudication (IC) volunteered for this study and were randomly allocated to either a control group (CPAD–IC) (n = 11), which received normal medical therapy and a treatment group (TPAD–IC) (n = 10), which received normal medical therapy treatment and a 12 month supervised exercise program. All participants underwent 2D joint angular kinematic analysis during normal walking to assess lower limb movement variability and walking speed. Between-group differences were analyzed via mixed measures ANOVA. The 12 month supervised exercise program made no significant impact on the lower limb movement variability or walking speed of the TPAD–IC group as determined by either intralimb joint coordination or single joint analysis techniques. Long term supervised exercise programs do not appear to influence the lower limb movement variability of PAD–IC patients.     

Reaching the Champions of Social Justice

Since the formation of the World Council of Churches (WCC) in 1948, the ecumenical voice against social injustice in the church and society has been strengthening. As one expression of unity among the fellowship, the WCC embarked in 2013 on a Pilgrimage of Justice and Peace to work, pray, and walk together for life-affirming economies, climate change, nonviolent peace building, and reconciliation and human dignity. Champions of these issues exist within the ecumenical movement. Yet one also finds that champions of one theme are pushing back on another theme. Sometimes it is due to diversity of contexts and biblical and theological interpretations. At other times it is due to unconscious bias about the holistic nature of God's mission of justice for all God's people and creation. This paper grapples with this question: Why are people who are so alive to economic and ecological injustice sometimes blind to racial and gender injustice? To answer this, I explore the existence of conscious and unconscious bias despite the many powerful ecumenical statements that have been issued on racial justice.     

The Lambeth Appeal and the Appeal of Britain

In 1920, the Lambeth Conference of Anglican bishops issued the “Appeal to All Christian People.” While much has been written on its genesis in 1920 and its impact on the later ecumenical movement and on Anglicanism, much less has been written about the relationship of the sort of ecumenism espoused by the Lambeth Appeal to the international political developments of the time. This article assesses the impact of the First World War and the Versailles Settlement on some of the assumptions underlying the Lambeth Appeal, examining how the appeal was in many ways a by-product of a new form of internationalism, which itself was closely related to the reinterpretation of the British Empire that emerged during the war.     

积极心理学的繁荣与演变——阴阳辩证哲理的回归

积极心理学是研究人类在适应社会生活中的积极特质、积极主观体验以及实现积极自我和成长的适应性认知和行为的科学。由Seligman(1998)兴起的积极心理学运动经过十年繁荣,在三个研究支柱的基础上增加第四个支柱积极的关系。由于积极心理学拒绝消极作为其中的范畴,Wong(2011)掀起积极心理学第二次浪潮,转向研究积极-消极的共生关系。并且,引用中国哲学思想,把阴阳之间的辩证互动原则作为积极心理学第二次浪潮的基础,研究积极和消极之间的动态平衡,以实现人类美好幸福生活和繁荣。     

合理性对汉语阅读中双字词语义预视效益的优势作用：眼动研究

语义预视效益(SPB)对于揭示阅读中读者能否从副中央凹提取高水平信息具有重要意义。关于SPB的产生机制仍然存在争议。本研究通过同时操控预视词的合理性和语义相关性考察了二者对汉语阅读中双字词SPB的影响。结果发现,合理性主效应显著,合理预视下目标词的注视时间显著短于不合理预视;语义相关性主效应不显著,未发现二者的交互作用。研究结果支持了语境匹配假说,进一步说明了汉语阅读中预视词的合理性对SPB的优势作用。     

社会性线索对内隐和外显元认知监控的影响

本研究以词图匹配材料为学习材料,以“大多数人选择的情况”为社会性线索,通过分析行为表现和眼动指标,探讨了社会性线索对内隐和外显元认知监控的影响。结果显示：（1）第一次信心判断时,外显信心判断显著高估,内隐信心判断较为准确。第二次信心判断时,在线索一致条件下,外显信心判断等级显著高于内隐信心判断。（2）在提供社会性线索阶段和第二次再认阶段,与线索一致条件相比,线索不一致条件下被提示项的注视时间更短,而未提示项的注视时间更长,且个体改变选择的次数显著增多。结果表明：内隐和外显元认知监测存在分离,内隐监测的准确性更高,外显监测受社会性线索的影响更大;而内隐和外显的元认知控制受社会性线索的影响趋同。     

特质自我控制对食物线索注意偏向的影响及干预：来自眼动的证据

采用眼动技术,以BMI指数处于正常范围的女性为被试,考察特质自我控制对食物线索注意偏向的影响以及注意偏向训练在改变注意偏向强度上的干预效果。结果发现,对于高热量食物线索,低特质自我控制水平女性表现出了更强的注意偏向;注意偏向训练有效降低了低特质自我控制水平女性对高热量食物线索注意偏向的强度。上述结果表明,特质自我控制影响个体对食物线索的注意偏向,注意偏向训练能有效改变个体对食物线索注意偏向的强度。     

汉语阅读中词切分研究进展

词切分指读者在文本阅读过程中将词从句子或语篇中切分出来以促进文本阅读与加工的过程。本文对近20 年来汉语词切分研究成果总结发现:词间空格、词素特性、词意识、词汇预期均可作为词切分的依据; 汉语阅读存在词n和词n+1两种切分,两种切分过程中字词加工均遵循交互激活假设,切分词n过程中字词加工的交互激活特点表现为字词同等相互影响,切分词n+1过程中字词加工的交互激活特点更多表现为词汇加工影响字加工; 重叠歧义词切分遵循多重激活假设,其中被激活的单词之间的竞争机制符合竞争假设,左侧词汇在这一竞争中具有优势,此外,重叠歧义词的切分受到词频,语境的影响。