Chronic amphetamine exposure during the preweanling period does not affect avoidance learning or novelty-seeking of adult rats

The purpose of the present study was to determine whether exposure to amphetamine during the preweanling period would impact the learning or reward processes of rats tested in adulthood. In three experiments we examined whether amphetamine treatment (0-10 mg/kg per day) on postnatal days 11-17 altered the subsequent performance of adult Sprague-Dawley rats on a step-down passive avoidance, active avoidance, or novelty-seeking task. There was no evidence that postnatal amphetamine exposure affected performance on any of these tasks. These results suggest that the long-term impact of pre- and postnatal psychostimulant exposure differs, because in utero stimulant treatment is known to produce learning deficits and decrease reinforcement efficacy of rats tested in adulthood.     

Client Advocacy and Collaboration with Insurance and Laboratory Testing Agencies: A Case Study Illustrating Genetic Counselor Roles

Genetic counseling and the many roles a genetic counselor must assume to provide quality genetic health care are becoming increasingly complex, especially when the genetic condition is rare, and DNA testing is costly and not yet routinely used. A case study of a couple with a family history of retinoblastoma and their pursuit of DNA testing for prenatal diagnosis is presented. The case study illustrates the instrumental role of the genetic counselor in advocating for clients for genetic services such as DNA testing and in educating insurance companies in the nature and importance of such services to achieve improved client health care outcomes.     

Effects of the Novel Acetylcholinesterase InhibitorN-Octyl-1,2,3,4-tetrahydro-9-aminoacridine on Locomotor Activity and Avoidance Learning in Mice

The acetylcholinesterase reversible inhibitorN-octyl-1,2,3,4-tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1–5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2–2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes.     

Eternity in an hour: experiences of time related to psychotherapy sessions

In this paper I consider the individual nature of the way a person develops senses of time. I suggest that something of a patient's early, unvoiced, experience is revealed through the temporal rhythms of interaction with the therapist. I refer to development, cycles of experience, metabolism, transgenerational emotions, experiences of beginnings and endings, early interactions with (m)other, together with narrative and its relation to unconscious processes. Experiences of time within the session indicate the nature of the feelings that are being lived, or refused life. I consider the paradox of living in the present and its relation to chronology. Lastly I give an example of the difficulty of timing comments when there is no flow of feeling, which is, itself, a communication.     

心理学的想象力与行动力

本文由心理学与内卷化问题切入讨论,提出心理学应该具备想象力与行动力.想象力的培养可以借助人类学、历史学、哲学等学科的视野.行动力则需要树立相应的观念,面向社区、生活与人民群众.知行合一或许是可能的选择.     

时-空整合影响图形识别的眼动研究

采用眼动追踪的方法对在不同方向(上、下、左与右)及距离(2.0°‘和4.0°视角)上先后出现的特征组合不同的图形识别过程进行了研究。结果表明。首先,对由不同颜色和形状构成的图形的识别受到图形特征组合的影响,视觉系统对颜色和形状的加工存在明显差异,与颜色加工相比,视觉系统需要更多的时间才能完成形状识别。此外,虽然图形识别的速度和准确性受运动方向与距离的影响较小,但在不同运动方向和距离上,视觉系统是通过改变眼动的时间和空间特性来完成识别任务的,视觉系统在识别过程中的这种时间与空间的整合特点还有待于进一步研究。     

Picture interpretation and Jungian typology

This study examined a Jungian picture interpretation schema, which utilizes a specific quadrant method. This proposed schema, which is used in training at the C. G. Jung Institute in Zürich, attaches significance to specific areas of a drawing. The upper left of a drawing is associated with the father; the lower left with the unconscious; the lower right with the mother; and the upper right with the future. Three questions served as the foci of this study: Is the schema valid? Do certain types within Jung's personality theory respond better than others to the schema? Does the schema work best when it elicits a strong affective response from the person who created the picture? Subjects took one of two tests: a space domain test, or a colour associative test. The results revealed only two significant effects: a positive association (in the space domain test) between unconscious material with the unconscious quadrant and a negative association (in the colour associative test) of mother material with the mother quadrant. These results suggest that the Jungian quadrant schema used to interpret drawings is invalid and of minimal practical utility. Other methods of picture interpretation are discussed as well as suggestions for future research that would be helpful to this field.     

ALZHEIMER'S DISEASE AND SOCIALLY EXTENDED MENTATION

Abstract: The leading accounts of the ethics of proxy decision making implicitly draw on internalist conceptions of the philosophy of mind, or so this essay tries to demonstrate. Using the views of Ronald Dworkin as its jumping-off point, the essay argues that accepting the sort of externalism associated with writers such as Putnam and Burge would alter Dworkin's conclusions concerning how we should respond to the current or precedent decisions of people suffering from dementia. Building on the views of Agnieszka Jawarska, it argues that accepting "active" externalism à la Clark and Chambers would provide currently competent people with new resources for establishing the authority of their present values over inconsistent values they might come to entertain should they become demented.     

European Bioethics II--Disparate Hopes and Fears: An Introduction

This introduction supplies further bearing points for the conceptualmap, which the introduction to the previous issue on Europeanbioethics (2008/1) had provided for sorting out the variousdimension in which the essays collected in these issues resembleand differ from each other. Special attention is devoted tocommunication, as diverse Christianities attend to differentpurposes, problems, and opportunities for normatively engaging(persuading, influencing, ruling, opposing, and converting)their surrounding secularized cultures. These differences reflectincompatible ways of conceiving Christ's acts of healing, asthese provide a model for His disciples' bioethics. These differencesalso reflect diversely rationalist and noetic epistemologies.The subtext concerns the haunting question about the enduringsustainability of a specifically Christian bioethics in Europe.As Schotsmans opts for a Roman Catholicism that is not recognizedas such by his Magisterium, as Muller transforms Protestantisminto a religiously nonhostile laicity, as Messer and Silva daBarbosa hope for the prophetic impact of communal "cities onthe hill," and as the Orthodox pursue the conversion of WesternEurope in Greek, Russian, and Rumanian, ongoing Divine miraclespresent the most realistic hope.     

儿童运动视觉表象操作水平的发展及影响因素

采用计算机软件控制实验,以暴露运动一段行程后进入遮蔽的光点为刺激物,光点以三种不同运动速度、三种不同运动行距组合呈现,要求儿童判断光点到达目标位置时按键反应。结果表明：5—19岁儿童运动视觉表象操作水平的发展存在5一8岁、11—14岁两个加速期;客体运动速度对运动视觉表象操作绩效有显著影响,5、8、11岁组快速较中速下．5．8岁组中速较慢速下操作准确性均有显著降低;客体运动行距对运动视觉表象操作绩效也有显著的影响．5、8、11岁组右目标位置下较中目标位置下操作准确性显著降低;性别对运动视觉表象操作水平无显著影响。