药物不良反应侵权诉讼问题研究

药物不良反应侵权诉讼是一种特殊的民事侵权诉讼。药品的生产者、药品经营者以及医疗机构都可能成为诉讼中的被告。药物不良反应侵权诉讼中的许多案件事实实行举证倒置。主要举证倒置事实有:药品缺陷、因果关系、免责事由、医疗过错等。     

Inducing Vocal Verbal Behavior in Children with Severe Language Delays Through Rapid Motor Imitation Responding

We conducted two experiments demonstrating the use of a rapid motor imitation sequence to evoke echoic and independent mands in three preschoolers with no vocal verbal behavior, who were unresponsive to alternative procedures. We further tested the procedure in the induction of echoics and independent tacts. The dependent variables for both experiments were echoics, mands, and tacts. In Experiment 1, we used a within subject multiple baseline design, across two mand and two tact forms, which were introduced in a counterbalanced order. In Experiment 2 we used a multiple baseline across subjects design with a tandem tact and mand training schedule, during which opportunities for echoic and independent mand training were contingent upon correct echoic and independent tact responses. Results showed that the rapid motor imitation antecedent was successful in inducing echoic and independent mands and tacts. Tacts required fewer opportunities than mands for mastery during the first experiment.     

知识类别和特点对内隐序列学习的影响

用序列学习中的反应时和错误个数间接测量被试的内隐知识,用再认成绩和预测成绩直接测量被试的外显知识,通过倒转不同的规则探讨了知识类别和特点对内隐序列学习的影响。结果表明：(1)内隐学习和外显学习可能分别依赖于两个独立的学习系统,且互不干扰;(2)当内隐序列学习既包含运动知识又包含概念知识时,知识类别和特点影响被试对序列知识的获得,被试较易获得运动知识;(3)在内隐序列学习中练习的数量也影响被试对序列知识的获得,序列学习是一个动态的过程。     

Parental beliefs and practices concerning motor development: Testing new tools

The parental beliefs on motor development (PB-MD) and the motor habits (MOHAB) questionnaires are new instruments measuring parental beliefs, practices, infant MOHAB, and environmental features regarding motor development. Psychometric properties of these questionnaires were tested using data of parents of 268 Dutch and Israeli infants aged 1-to-8-months. Face- and convergent validity of both questionnaires, as well as internal consistency and test–retest reliability of the PB-MD were satisfactory. Exploratory factor analysis revealed five factors in the PB-MD. Altogether, both questionnaires are valid, reliable and culturally sensitive instruments potentially useful for research and clinical practice.     

Fine motor skills enhance lexical processing of embodied vocabulary: A test of the nimble-hands,nimble-minds hypothesis

Research suggests that fine motor skills (FMS) are linked to aspects of cognitive development in children. Additionally, lexical processing advantages exist for words implying a high body–object interaction (BOI), with initial findings indicating that such words in turn link to children’s FMS—for which we propose and evaluate four competing hypotheses. First, a maturational account argues that any links between FMS and lexical processing should not exist once developmental variables are controlled for. Second, functionalism posits that any link between FMS and lexical processing arises due to environmental interactions. Third, the semantic richness hypothesis argues that sensorimotor input improves lexical processing, but predicts no links between FMS and lexical processing. A fourth account, the nimble-hands, nimble minds (NHNM) hypothesis, proposes that having greater FMS improves lexical processing for high-BOI words. In two experiments, the response latencies of preschool children (n?=?90, n?=?76, ages?=?5;1) to 45 lexical items encompassing high-BOI, low-BOI, and less imageable words were measured, alongside measures of FMS, reasoning, and general receptive/expressive vocabulary. High-BOI words appeared to show unique links to FMS, which remained after accounting for low-BOI and less imageable words, general vocabulary, reasoning, and chronological age. Although further work is needed, the findings provide initial support for the NHNM hypothesis.     

Motor imagery in spinal cord injured people is modulated by somatotopic coding,perspective taking,and post‐lesional chronic pain

Motor imagery (MI) allows one to mentally represent an action without necessarily performing it. Importantly, however, MI is profoundly influenced by the ability to actually execute actions, as demonstrated by the impairment of this ability as a consequence of lesions in motor cortices, limb amputations, movement limiting chronic pain, and spinal cord injury. Understanding MI and its deficits in patients with motor limitations is fundamentally important as development of some brain–computer interfaces and daily life strategies for coping with motor disorders are based on this ability. We explored MI in a large sample of patients with spinal cord injury (SCI) using a comprehensive battery of questionnaires to assess the ability to imagine actions from a first‐person or a third‐person perspective and also imagine the proprioceptive components of actions. Moreover, we correlated MI skills with personality measures and clinical variables such as the level and completeness of the lesion and the presence of chronic pain. We found that the MI deficits (1) concerned the body parts affected by deafferentation and deefferentation, (2) were present in first‐ but not in third‐person perspectives, and (3) were more altered in the presence of chronic pain. MI is thus closely related to bodily perceptions and representations. Every attempt to devise tools and trainings aimed at improving autonomy needs to consider the cognitive changes due to the body–brain disconnection.     

Comparing response blocking and response interruption/redirection on levels of motor stereotypy: Effects of data analysis procedures

Autism spectrum disorder (ASD) is marked by deficits in social communication and the presence of restrictive and/or repetitive behaviors or interests. Motor stereotypy is a form of repetitive behavior that is common in ASD. Response Interruption and Redirection (RIRD) and response blocking (RB) are two interventions found to be efficacious in reducing motor stereotypy. However, the current literature presents with inconsistencies regarding the relative efficacy of these two procedures. Thus, we sought to replicate and extend previous literature by evaluating the efficacy of both interventions on reducing motor stereotypy among 3 individuals with ASD. We also sought to evaluate how variations in data analysis affected the interpretation of treatment outcomes. Results indicated that both interventions were equally efficacious at reducing stereotypy when analyzing data exclusive of treatment‐implementation time. However, when analyzing total session time data, RB produced greater and more sustained reductions in stereotypy across all participants. These results emphasize the importance of data analysis decision‐making in evaluating intervention outcomes.     

Cognitive Bias for the Distribution of Ball Landing Positions in Amateur Tennis Players (Cognitive Bias for the Motor Variance in Tennis)

This study aimed to investigate whether the isotropy bias (estimating one's own motor variance as an approximately circular distribution rather than a vertically elongated distribution) arises in tennis players for the estimation of the two-dimensional variance for forehand strokes in tennis (Experiment 1), as well as the process underlying the isotropy bias (Experiment 2). In Experiment 1, 31 tennis players were asked to estimate prospectively their distribution of ball landing positions. They were then instructed to hit 50 forehand strokes. We compared the eccentricity of the ellipse calculated from estimated and observed landing positions. Eccentricity was significantly smaller in the estimated ellipse than in the observed ellipse. We assumed that the isotropy bias for the estimated ellipse comes from the process of variance estimation. In Experiment 2, nine participants estimated the 95% confidence interval of 300 dots. Eccentricity was significantly smaller in their estimated ellipses than it was in the ellipses for the dots, though the magnitude of bias decreased for the estimation of dots. These results suggest that the isotropy bias in tennis ball landing position includes the bias of recognizing landing position and the bias of estimating the ellipse confidence interval from the recognized landing position.     

Motivational effects of enhancing expectancies and autonomy for motor learning: An examination of the OPTIMAL theory

The OPTIMAL theory proposes that enhancing expectancies and autonomy facilitate motor performance and learning (Wulf & Lewthwaite). Present study with two experiments aimed to examine this proposition by using a modified dart throwing as motor task. In both experiments, motor learning (i.e., retention test) was enhanced by practice conditions, which enhance expectancies for future performance and support learners’ autonomy. Moreover, they led to significantly superior self-efficacy scores during all acquisition phase, retention, and transfer tests. Findings of the present study provided support for propositions of the OPTIMAL theory. Results are discussed in terms of motivational aspects of enhancing expectancies and autonomy and their role on facilitating motor learning.     

Potential negative consequences of mindfulness in the moral domain

Mindfulness is a state of paying conscious and nonjudgmental attention to present-moment experiences. Previous research relates this state to more effective emotion regulation and less emotion reactivity. We therefore hypothesized an attenuating effect of a mindfulness exercise on moral reactions that usually results from a bad conscience when having caused harm. Across five studies, we experimentally induced mindfulness via a short breathing exercise and then assessed harm-based moral reactions. As hypothesized, participants in the mindfulness (vs. control) exercise condition showed (i) attenuated repair intentions after having read a scenario in which participants caused harm to a friend (Study 3) and (ii) attenuated intentions to change harm-causing eating habits (Study 4). Results of Studies 1, 2 and 5 did not provide evidence for our hypothesis. A following meta-analysis across all five studies yielded an overall significant effect of mindfulness in the harm-condition, providing preliminary evidence for a potential downside to mindfulness.