Molecular geneticists and moral responsibility: “maybe if we were working on the atom bomb I would have a different argument”

Senior molecular geneticists were interviewed about their perceptions of the ethical and social implications of genetic knowledge. Inductive analysis of these interviews identified a number of strategies through which the scientists negotiated their moral responsibilities as they participated in generating knowledge that presents difficult ethical questions. These strategies included: further analysis and application of scientific method; clarification of multiple roles; negotiation with the public through public debate, institutional processes of funding, ethics committees and legislation; and personal responsibility.     

Human–Computer Interaction in Face Matching

Automatic facial recognition is becoming increasingly ubiquitous in security contexts such as passport control. Currently, Automated Border Crossing (ABC) systems in the United Kingdom (UK) and the European Union (EU) require supervision from a human operator who validates correct identity judgments and overrules incorrect decisions. As the accuracy of this human–computer interaction remains unknown, this research investigated how human validation is impacted by a priori face‐matching decisions such as those made by automated face recognition software. Observers matched pairs of faces that were already labeled onscreen as depicting the same identity or two different identities. The majority of these labels provided information that was consistent with the stimuli presented, but some were also inconsistent or provided “unresolved” information. Across three experiments, accuracy consistently deteriorated on trials that were inconsistently labeled, indicating that observers’ face‐matching decisions are biased by external information such as that provided by ABCs.     

A computer-based program to teach braille reading to sighted individuals

Instructors of the visually impaired need efficient braille‐training methods. This study conducted a preliminary evaluation of a computer‐based program intended to teach the relation between braille characters and English letters using a matching‐to‐sample format with 4 sighted college students. Each participant mastered matching visual depictions of the braille alphabet to their printed‐word counterparts. Further, each participant increased the number of words they read in a braille passage following this training. These gains were maintained at variable levels on a maintenance probe conducted 2 to 4 weeks after training.     

Automated Integrative Complexity: Current Challenges and Future Directions

Automating integrative complexity is fraught with many challenges. To address these challenges, we discuss the tension between a specificity approach and a more flexible multiple‐pass approach, the multifaceted nature of the complexity construct, the gold standard for complexity measurement, the difficulty of human scoring and its consequences for automation, and some ways forward for creating the best complexity measurements. In so doing, we present new data demonstrating (1) initial evidence for the validity of a new automated system for measuring two different forms of complexity (elaborative and dialectical), (2) the danger of constructing measurements in a purely ad hoc fashion that ignores prospective testing, (3) human‐to‐computer correspondence is in part a function of human‐to‐human correspondence, (4) human‐to‐computer correspondence increases systematically as one uses tests with larger units of analysis, and (5) the lack of correspondence of different systems (both human and automated) may occur in part because they were designed for different units of analysis.     

直肠间质瘤致下消化道大出血1例报告

胃肠道间质瘤是一种发生于消化道的少见的间叶肿瘤,直肠间质瘤更为罕见,在直肠肿瘤中的发生率0．1％以下。直肠问质瘤的临床表现无特异性,与其他直肠肿瘤相似,随肿瘤逐渐增大可表现为排便习惯改变、便血、排便困难等。临床确定诊断困难。手术治疗是能够治愈直肠问质瘤的唯一方法。格列卫作为一线化疗药物对术前降期及改善预后都有良好疗效。本例患者因下消化道大出血入院,肿瘤近肛缘,术中病理考虑为直肠闻质瘤,完整切除肿瘤后行保肛术。术后应用格列卫,随诊3个月无复发、转移。     

The Association Between Psychological Well-Being and Problematic Use of Internet Communicative Services Among Young People

Previous studies on problematic Internet use have focused almost exclusively on the fact that presence of negative functioning, such as social anxiety, depressive symptoms, or loneliness, represents a risk factor for unhealthy use of the web. For this reason the aim of the present study was to investigate the association between psychological well-being dimensions and problematic use of Internet communicative services. In the current study 495 undergraduate students were recruited. The Italian adaptations of the Psychological Well-being Scales and the Generalized Problematic Internet Use Scale 2 (GPIUS2) were used to assess psychological well-being dimensions and generalized problematic Internet use, respectively. Psychological well-being dimensions explained a significant portion of variance for the GPIUS2 total score levels, after controlling for sex, age, and occupational status. The levels of Autonomy, Environmental Mastery, and Positive Relations with Others acted as significant negative predictors of the tendency to use the web for regulating negative feelings, compulsive use of the web, and the negative outcomes that can arise as a result. The overall findings of the present study provide preliminary evidence that low psychological well-being is associated with problematic use of Internet communicative services.     

An evaluation of computer-based programmed instruction for promoting teachers' greetings of parents by name

Although greeting parents by name facilitates subsequent parent-teacher communication, baseline measures revealed that 4 preschool teachers never or rarely greeted parents by name during morning check-in. To promote frequent and accurate use of parents' names by teachers, the effects of a fully automated computerized assessment and programmed instruction (CAPI) intervention were evaluated in a multiple baseline design. The CAPI intervention involved assessment and training of relations among parents' and children's pictures and names, and produced rapid learning of parent names. The CAPI intervention also resulted in substantial improvements in the classroom use of parents' names for 3 of the 4 teachers; however, a supervisor-mediated feedback package (consisting of instructions, differential reinforcement, and error correction) was necessary to maintain name use for 2 of those teachers. The practical strengths and limitations of computer-based teacher training are discussed.     

Linear instability signals the initiation of motion of a twin plane under load

This letter presents a study of the atomic mechanism of the initiation of motion of a static twin plane under applied mechanical load in a model shape-memory material. By tracking the deformation under load and using linear stability analysis, we find that the eigenvalues of the Hessian matrix provide an indicator of the initiation of motion of the twin plane. The initiation of motion is signaled by a linear instability and a drop in the lowest eigenvalue to zero as well as a sharp drop in higher eigenvalues. Additionally, by comparing with direct molecular dynamics, we see that the eigenmode associated with the zero eigenvalue is found to accurately predict the initial mode of motion. We also find that the initial motion occurs through the formation of a stacking fault just ahead of the existing twin plane and the broadening of the stacking fault drives further transformation.     

胃肠道肿瘤的分子靶向治疗:未来的方向?

分子靶向治疗是这几年来消化道肿瘤治疗领域的热门话题.这类新一代的分子靶向生物治疗模式,将在临床治疗肿瘤实践中具有广阔的应用前景.从事肿瘤研究的临床医务人员需要综合归纳这些信息,融汇入自己的认知将之合理应用于患者.我们将真正进入传统的细胞毒性药物攻击与非细胞毒性靶向性药物相结合使用的时代,真正实现延长患者的生命,改善其生活质量的目标.     

A goal model of catharsis

Although research in social psychology has repeatedly refuted the idea that aggression reduces subsequent aggression (e.g., Bushman, 2002), we suggest a more fine-grained analysis of catharsis. We will present and discuss a social-cognitive goal model of cathartic effects in aggression that predicts under which conditions aggression increases or reduces subsequent aggression. The model assumes that the accessibility of aggression-related constructs is a function of goal fulfilment: Prior to goal fulfilment constructs related to the goal are highly accessible in order to facilitate goal fulfilment. However, after goal fulfilment this heightened accessibility loses its functionality and aggressive constructs are consequently inhibited. In the present article we will review empirical work testing this model. Moreover, we will extend this model to the effects of violent computer games. Finally we will discuss theoretical challenges and applied relevance of our model for intervention strategies aimed at reducing aggression.