比较视阈的中美医学伦理学教学——以武汉大学与芝加哥大学为例

中美两国都很重视医者人文素质的培养, 都重视医学伦理学教学。在与芝加哥大学的交流活动中, 武汉大学积极总结经验, 锐意改革, 取得了若干成果。其值得推广的经验包括:注重医学伦理教育的持续性, 构建长效教育机制;注重医学基础课程的道德教化功能, 形成隐性的医德渗透机制;注重临床医生的参与, 确立理论与实践的融通机制;审视中国传统文化特色与医疗现状, 培育域外教学方法的本土化机制;重视医学伦理学学科建设, 建立生命伦理学与医学伦理学的整合机制。     

视觉空间伪忽视与表征伪忽视神经机制的异同

伪忽视是指个体存在的轻微偏左的不对称空间注意,而视觉空间伪忽视和表征伪忽视是其两种主要表现形式。研究初期,研究者认为两种伪忽视基于相同的注意定向左偏机制,但近年来研究发现,它们存在神经机制的差异。本文主要从两种伪忽视神经机制的异同出发,梳理近期研究结果,以期增进对伪忽视的理解。未来研究可以从认知时间进程角度或设计更为完善的研究范式进一步探讨这两种伪忽视神经机制的异同。     

Improving Delivery Behaviors During Exposure for Pediatric OCD: A Multiple Baseline Training Trial With Community Therapists

This study tested whether a new training tool, the Exposure Guide (EG), improved in-session therapist behaviors (i.e., indicators of quality) that have been associated with youth outcomes in prior clinical trials of exposure therapy. Six therapists at a community mental health agency (CMHA) provided exposure therapy for 8 youth with obsessive–compulsive disorder (OCD). Using a nonconcurrent multiple baseline design with random assignment to baseline lengths of 6 to 16 weeks, therapists received gold-standard exposure therapy training with weekly consultation (baseline phase) followed by addition of EG training and feedback (intervention phase). The primary outcome was therapist behavior during in-session exposures, observed weekly using a validated coding system. Therapist behavior was evaluated in relation to a priori benchmarks derived from clinical trials. Additional outcomes included training feasibility/acceptability, therapist response to case vignettes and beliefs about exposure, and independent evaluator-rated clinical outcomes. Three therapists reached behavior benchmarks only during the EG (intervention) phase. Two therapists met benchmarks during the baseline phase; one of these subsequently moved away from benchmarks but met them again after starting the EG phase. Across all therapists, the percentage of weeks meeting benchmarks was significantly higher during the EG phase (86.4%) vs. the baseline phase (53.2%). Youth participants experienced significant improvement in OCD symptoms and global illness severity from pre- to posttreatment. Results provide initial evidence that adding the EG to gold-standard training can change in-session therapist behaviors in a CMHA setting.     

错失恐惧对亲社会行为的影响

网络信息的纷繁复杂,让人们担忧因错失信息而导致自身的利益受损,本研究探讨这种现象的加剧对个体的亲社会行为的影响。本研究分别使用问卷法（研究1）和实验法（研究2）,探究错失恐惧对亲社会行为的影响以及在其过程中人际安全感的中介作用和基本心理需要满足的调节作用。结果发现：（1）个体的错失恐惧程度负向预测了其亲社会行为;（2）人际安全感在错失恐惧对亲社会行为的影响中起中介作用,高的错失恐惧水平会降低个体的人际安全感,从而减少个体的亲社会行为;（3）基本心理需要满足在错失恐惧对亲社会行为的负向预测作用中起调节作用,当个体的基本心理需要满足程度低的时候,错失恐惧对亲社会行为的消极影响显著增强。     

双眼视差的神经机制与知觉学习效应

双眼瞳距使得空间某物体在左右眼视网膜的成像存在微小位置差异, 这种差异被称为双眼视差(binocular disparity), 是立体视知觉的重要信息来源。对双眼视差的心理物理学研究始于18世纪初, 迄今已有接近两百年的历史。近年来, 双眼视差研究主要集中在两方面。其一是用电生理、脑成像技术考察双眼视差在视觉背、腹侧通路的模块化表征, 其脑区表征反映出视觉系统的层级式、平行式加工规律。其二是应用知觉学习范式研究双眼视差的可塑性。未来研究应综合脑成像和神经调控技术考察双眼视差的神经机制及其学习效应, 包括双眼视差与多种深度线索间的信息整合和交互作用。应用方向上, 可结合虚拟现实等技术优化训练范式, 实现立体视力的康复和增强。     

孤独症儿童动作发展障碍的神经机制

动作发展障碍(Developmental motor disorders)是孤独症谱系障碍的常见特征。通过系统回顾孤独症儿童动作发展障碍的神经科学研究, 发现γ-氨基丁酸和5-羟色胺浓度的改变及γ-氨基丁酸相关蛋白和Shank蛋白的表达异常不仅会损害中枢神经系统的发育, 而且还能导致突触兴奋性与抑制性失衡, 进而改变孤独症儿童小脑和大脑皮层运动区的功能连接。孤独症儿童小脑、基底神经节和胼胝体结构的改变对全脑的连通性产生了负面影响。神经生化机制和脑结构的异常共同导致了脑功能的异常, 最终造成孤独症儿童的动作发展障碍。此外, 动作发展障碍与孤独症核心症状共同的神经基础主要包括镜像神经元系统紊乱, 丘脑、基底神经节和小脑异常以及SLC7A5和PTEN 基因突变。未来研究需要关注与运动密切相关的其他神经递质, 如乙酰胆碱和多巴胺; 探索动作发展障碍神经网络的动态机制及其形成; 剖析该障碍的神经机制和自闭症核心症状神经机制的相互作用。     

How our work influences who we are: Testing a theory of vocational and personality development over fifty years

This study examines the developmental influences of occupational environments on personality traits from childhood to adulthood. We test aspects of a theory of vocational and personality development, proposing that traits develop in response to work experience following corresponsive and noncorresponsive mechanisms. We describe these pathways in the context of situations of vocational gravitation and inhabitation. In a sample from the Hawaii personality and health cohort (N = 596), we examined associations of childhood and adulthood personality traits, with occupational environments profiled on the RIASEC model. Mediations tests confirmed that work influenced personality development from childhood to adulthood for Openness/Intellect. We observed multiple reactivity effects of occupation environments on adulthood traits that were not associated with corresponding selection effects.     

Maximizing data quality and shortening survey time: Three-form planned missing data survey design

Simulation studies have shown the three-form planned missing data design efficiently collects high quality data while reducing participant burden. This methodology is rarely used in sport and exercise psychology. Therefore, we conducted a re-sampling study with existing sport and exercise psychology survey data to test how three-form planned missing data survey design implemented with different item distribution approaches effect constructs’ internal measurement structure and validity. Results supported the efficacy of the three-form planned missing data survey design for cross-sectional data collection. Sample sizes of at least 300 (i.e., 100 per form) are recommended for having unbiased parameter estimates. It is also recommended items be distributed across survey forms to have representation of each facet of a construct on every form, and that a select few of these items be included across all survey forms. Further guidelines for three-form surveys based upon the results of this resampling study are provided.     

内隐创业领导与多层次积极追随力的互动机制

多层次积极追随力是创业企业成长的重要保证。已有研究强调不同显性领导对积极追随力的影响, 结论存在较多争议。对此, 以内隐领导理论为基础, 构建了“内隐创业型领导-积极追随力”的多层次互动模型。根据此模型, 内隐创业型领导通过关系认同和领导代表性对个体与团队积极追随力产生促进作用; 团队积极追随力通过积极心理资本塑造内隐创业型领导; 团队差序氛围、员工传统性和领导特质调节焦点是互动关系重要的边界条件。     

老年人视听觉整合的影响因素及其神经机制

老年人的视听觉整合能力强于还是弱于年轻人, 目前尚存在很大争议。对老年人视听觉整合脑机制的研究, 将为老年人脑保健提供一种科学的跨通道整合方案。基于已有研究成果从两方面进行论述：1)影响老年人视听觉整合的因素, 包括刺激的物理属性、刺激呈现的时空关系以及刺激得到的注意资源。2)老年人视听觉整合效应。研究表明, 一方面, 老年人表现出更高的功能连接性、网络效率和较强的视听觉整合效应, 如：老年人在后顶叶、内侧前额叶和左前额叶等脑区有较强的激活, 额中央区的P2振幅表现出超加性; 老年人比年轻人的视听觉整合发生较早并有较长的延伸。另一方面, 老年人有较长的反应时和较弱的整合促进, 以及对视听觉刺激进行反应时颞上回脑区的振幅弱于年轻人。简单刺激诱发的老年人视听觉整合为进一步揭示整合机制提供了可靠的基础, 但是对于复杂情景下的视听觉信息整合加工机制仍待探究。