用药动作线索诱发海洛因戒断者的镜像神经活动:一项fMRI研究

相关线索能够诱发药物依赖者的心理渴求,而健康人不会对相关线索产生心理渴求。15名海洛因成瘾者和12名没有任何物质滥用的健康被试参与实验,收集了他们在观看相关线索与对照线索时的脑神经活动。结果发现,药物线索能够诱发戒断者更多脑区的活动,包括扣带回和楔前叶。两组被试在对照动作线索刺激诱发作用下,其颞叶、顶叶均出现了较为一致的活动。在用药动作线索诱发作用下,戒断组双侧颞中回、双侧顶下小叶、左侧顶上小叶和右侧额下回显示出显著活动,并且与对照动作线索激活脑区一致;健康组被试除枕叶-颞叶联合区外,没有出现显著的脑区活动。以上结果表明,用药动作线索诱发了海洛因戒断者颞中回、顶下小叶、额下回等镜像神经系统的活动,这些脑区对不同类型的相关线索十分敏感,它们可能通过对用药动作的心理模拟,参与了用药动作线索的快速自动化加工。     

认知判断中手部动作模拟的fMRI研究

该研究采用功能磁共振成像技术,考察不同条件下进行工具认知判断时手部姿势对认知判断的影响及动作模拟的神经机制。实验发现：手部姿势存在显著的主效应,冲突手部姿势条件下反应时最慢,且冲突手部姿势条件下与不冲突手部姿势条件下、自然状态条件下反应时存在显著差异,自然状态条件与不冲突手部姿势条件下反应时不存在显著差异。另外,f MRI成像结果发现,额中回、额下回、顶下小叶以及辅助运动区在自然状态下有显著激活,表明个体在进行认知判断过程中有动作模拟过程;海马结构、扣带回及楔前叶等与记忆有关的脑区有显著激活,表明身体经验在认知过程的作用。总的研究表明,不同的手部姿势状态对认知判断有不同影响,冲突手部姿势会对动作模拟产生干扰作用,手部动作模拟的神经机制主要涉及镜像神经元区,且在认知判断时存在具身效应。     

Divided stimulus control: Which key did you peck,or what color was it?

Responding on concurrent schedules produced a conditional discrimination (Phases 1 and 2), asking either which peck produced the event, or which color the keys were when the event was produced. In Phases 3 and 4, reinforcer delivery or a delay in blackout was interpolated between responding and the conditional discrimination. In Phase 1, location versus color discrimination accuracy was controlled by the relative reinforcer frequency for correct responses to these questions (divided stimulus control). In Phases 2 to 4, relative reinforcer frequency for correct responses to these questions was .5, and the relative frequency with which concurrent‐schedule responses produced the questions was varied. This variation had no clear effect on the accuracy of reporting Location or Color. These results are consistent with the model of divided control suggested by Davison and Elliffe (2010). Arranging a 3‐s reinforcer between responding and choice decreased both color and location accuracy, but a 3‐s delay only decreased location accuracy. Thus, in concurrent‐schedule performance, both ambient stimuli prior to a reinforcer and the location of the just‐reinforced response are available as discriminative stimuli following the reinforcer. Control of postreinforcer responding is divided between these according to their association with the relative frequency of subsequent reinforcers.     

共情的神经机制

共情是社会认知中不可或缺的一部分,是维系积极社会关系的社会动机因素。近年来,脑成像技术的发展为共情的神经机制研究开拓了新的视野,共情的神经机制研究取得了很大的进展。共情神经机制的研究主要包括共情的"表征共享"基础、共情的镜像神经元特征、共情调节的早期、晚期评价模型、共情的调节因素以及特殊个体的共情研究。在此基础上指出现有研究中存在的问题和未来研究的方向。     

Emotions in action through the looking glass1

Abstract: The paper aims at highlighting how our primary understanding of others’ actions is rooted in the mirror mechanism. To this end, the anatomical architecture of the mirror neuron system for action will be outlined as well as its role in grasping goals and intentions in others’ motor behaviour. One further step through the looking glass of social cognition will be referring to the ubiquitous emotional colouring of actions and considering its links with the motor domain. This will allow a clearer perspective on the mechanism underlying our abilities for emotional understanding and on cases in which these abilities are amiss, as in autistic spectrum disorders.     

Mirrors and Misleading Appearances

Although philosophers have often insisted that specular perception is illusory or erroneous in nature, few have stressed the reliability and indispensability of mirrors as optical instruments. The main goal of this paper is to explain how mirrors can contribute to knowledge and at the same time be a source of systematic errors and misleading appearances. To resolve this apparent paradox, I argue that mirrors do not generate perceptual illusions or misperceptions, by defending a view of mirrors as transparent and invisible visual media. I then consider the reasons for which mirrors are said to be misleading. Contrary to the illusory account, I defend a nonperceptual approach to the errors attributable to mirrors, which analyses the kind of errors generated by the use of mirrors in terms of false judgments. I further show that a nonperceptual view of errors extends to all of the cases in which a sensorimotor adaptation is required, such as perception through magnifying or inversing lenses.     

康德宗教哲学对我们的启示

在这个演讲里,笔者试图从康德的哲学与宗教观里发现西方文化的心理镜像结构,并以此来参照对比中国文化的心灵结构,结合个人的经验对二者都有所论衡。     

Test-dependent expression of behavioral syndromes: A study of aggressiveness,activity, and stress of chub

Aggressiveness has been one of the behavioral traits most examined with various standard testing methods. We used two distinct methods (the mirror and the real opponent tests) to evaluate individual aggression and relate it to the activity and individual stress of chub (Squalius cephalus L.). Three hypotheses were formulated and tested: (a) there is a significant positive relationship between the aggressiveness of individuals measured with the mirror and the real opponent tests, indicating their convergent validity; (b) the irregularities in response to the aggressiveness and activity tests lead to the context-specific expression of the behavioral syndromes; and (c) there is a significant positive relationship between the stress induced in individuals by both tests of aggressiveness, demonstrating individually consistent stress-coping strategies. The first and the second hypothesis were confirmed, while the third hypothesis was rejected. Our results suggest that particular tests of aggressiveness could act as a situation with high strength, leaving little variation between individual responses. Thus, we propose that for the proper interpretation of various studies using different tests to study identical behavioral traits, it is important to consider the convergent validity of not only the tested behavioral traits but also the individual stress responses. The chub also showed stress relieve through aggressiveness, suggesting the species as a prospective animal model to the study interaction between the stress and the aggressiveness. A detailed aggression ethogram of chub was provided to facilitate the use of this specie in future studies.     

Models that allow us to perceive the world more accurately also allow us to remember past events more accurately via differentiation

Differentiation is a theory that originally emerged from the perception literature and proposes that with experience, the representation of stimuli becomes more distinct from or less similar to the representation of other stimuli. In recent years, the role of differentiation has played a critical role in models of memory. Differentiation mechanisms have been implemented in episodic memory models by assuming that information about new experiences with a stimulus in a particular context accumulates in a single memory trace and these updated memory traces become more distinct from the representations of other stimuli. A key implication of such models is that well encoded events are less confusable with other events. This prediction is particularly relevant for two important phenomena. One is the role of encoding strength on memory. The strength based mirror effect is the finding of higher hit rates and lower false alarm rates for a list composed of all strongly encoded items compared to a list composed of all weakly encoded items. The other is output interference, the finding that accuracy decreases across a series of test trials. Results from four experiments show a tight coupling between these two empirical phenomena such that strongly encoded target items are less prone to interference. By proposing a process model and evaluating the predictions of the model, we show how a single theoretical principle, differentiation, provides a unified explanation for these effects.