排序方式: 共有101条查询结果,搜索用时 15 毫秒
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Arne Öhman 《Current directions in psychological science》2002,11(2):62-66
The human face is an evolved adaptation for social communication. This implies that humans are genetically prepared to produce facial gestures that are automatically decoded by observers. Psychophysiological data demonstrate that humans respond automatically with their facial muscles, with autonomic responses, and with specific regional brain activation of the amygdala when exposed to emotionally expressive faces. Attention is preferentially and automatically oriented toward facial threat. Neuropsychological data, as well as a rapidly expanding brain-imaging literature, implicate the amygdala as a central structure for responding to negative emotional faces, and particularly to fearful ones. However, the amygdala may not be specialized for processing emotional faces, but may instead respond to faces because they provide important information for the defense appraisal that is its primary responsibility. 相似文献
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ABSTRACT— A growing body of evidence suggests emotion boosts memory accuracy to an extent but affects the subjective sense of recollection even more. The result is vivid memories for emotional events that are held with confidence but that may be surprisingly inaccurate in their details. We examine the neural circuitry underlying emotion's impact on memory and the subjective sense of recollection to provide insight into this puzzling phenomenon. This research suggests that for emotional stimuli the quality and strength of memory for a few details may mediate judgments of recollection, whereas for neutral stimuli the quantity of contextual details may be more important. Finally, we speculate that the enhanced subjective sense of recollection with emotion, in the absence of absolute veridicality, may have evolved to enable fast and unambiguous decision making in emotional situations. 相似文献
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Luiz Pessoa 《Trends in cognitive sciences》2017,21(5):357-371
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Ribeiro AM Barbosa FF Munguba H Costa MS Cavalcante JS Silva RH 《Neurobiology of learning and memory》2011,95(4):433-440
Numerous studies have suggested that the amygdala is involved in the formation of aversive memories, but the possibility that this structure is merely related to any kind of fear sensation or response could not be ruled out in previous studies. The present study investigated the effects of bilateral inactivation of the amygdaloid complex in rats tested in the plus-maze discriminative avoidance task. This task concomitantly evaluates aversive memory (by discrimination of the two enclosed arms) and innate fear (by open-arm exploration). Wistar rats (3-5 months-old) were implanted with bilateral guide cannulae into basolateral amygdala. After surgery, all subjects were given 1 week to recover before behavioral experiments. Afterwards, in experiment 1, 15 min prior to training, 0.5 μl of saline or muscimol (1 mg/ml) was infused in each side via microinjection needles. In experiment 2 the animals received injections immediately after the training session and in experiment 3 rats were injected prior to testing session (24 h after training). The main results showed that (1) pre-training muscimol prevented memory retention (evaluated by aversive arm exploration in the test session), but did not alter innate fear (evaluated by percent time in open arms); (2) post-training muscimol impaired consolidation, inducing increased percent in aversive arm exploration in the test session and (3) pre-testing muscimol did not affect retrieval (evaluated by aversive enclosed arm exploration in the test session). The results suggest that amygdala inactivation specifically modulated the learning of the aversive task, excluding a possible secondary effect of amygdala inactivation on general fear responses. Additionally, our data corroborate the hypothesis that basolateral amygdala is not the specific site of storage of aversive memories, since retention of the previously learned task was not affected by pre-testing inactivation. 相似文献
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Munguba H Cabral A Leão AH Barbosa FF Izídio GS Ribeiro AM Silva RH 《Neurobiology of learning and memory》2011,95(4):527-533
Endocannabinoids (eCBs) modulate a variety of brain functions via activation of the widely expressed CB1 receptor. One site of high density of this receptor is the basolateral amygdala (BLA), a structure involved in the formation of aversive memories. The activation and blockade of CB1 receptors by systemic or hippocampal drug administrations have been shown to modify memory processing. However, little is known about the role of the BLA endocannabinoid system in aversive memories. Additionally, BLA endocannabinoid transmission seems to be related to emotional states, but the relevance of these effects to memory formation is still unknown. In this study we investigated the effects of the eCB anandamide (AEA) and the CB1 antagonist/inverse agonist AM251 infused into the BLA on the acquisition of an aversive memory task, concomitantly evaluating basal anxiety levels in rats. Male rats received pre-training micro-injection of AEA, AM251 or vehicle bilaterally into the BLA, and were studied with the plus-maze discriminative avoidance task (a paradigm that allows concomitant and independent evaluation of anxiety-like behavior and the memory of an aversive task). Our results showed that AEA into the BLA before training prevented memory retrieval 24 h later, as evaluated by exploration of the aversive arm of the maze, while AM251 into the BLA did not interfere with animals' performance. In addition, AEA had no effect on anxiety-like behavior (as evaluated by open arm exploration and risk assessment), while AM251 induced an anxiogenic effect. Our data indicate an important role of BLA CB1 receptors in aversive memory formation, and suggest that this involvement is not necessarily related to a possible modulation of anxiety states. 相似文献
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前瞻记忆是指对预定事件或行为的记忆。本文总结了前瞻记忆脑机制相关的文献,介绍了前额皮层、丘脑,内侧颞叶等脑区域在前瞻记忆中的作用,并通过分析注意缺陷多动障碍儿童、老年痴呆症患者、酒精依赖症和内侧颞叶癫痫患者前瞻记忆的表现,从临床角度深入探讨了前瞻记忆神经机制的问题。证据表明,前额皮层参与前瞻记忆的编码、提取和监控过程,与意向保持也有密切的关系;丘脑与意向的执行有关,并且与前额叶互动在前瞻记忆监控中起着重要的作用;内侧颞叶与编码来源的提取和意向的激活都有密切的关系。研究认为前额皮层在前瞻记忆加工过程中起着核心的作用,同时与丘脑、内侧颞叶等区域相互作用,共同成为前瞻记忆编码、保持、提取、执行的神经基础。 相似文献
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在个体生命早期遭遇的长期或重大的应激经历会显著增加个体罹患抑郁、焦虑等心理疾患的风险, 而情绪调节能力的损伤是引发这些心理疾患的重要因素之一。以人类为对象的行为实验和调查研究表明, 早期应激不仅会影响日常生活中情绪调节策略的使用, 还会对情绪调节能力造成影响, 其影响方向可能与早期应激的严重程度有关。目前, 大部分研究表明严重的早期应激会损伤情绪调节能力, 但中度的早期应激也可能提高情绪调节能力。更为整合性的研究表明情绪调节能力中介了早期应激和各类疾患之间的关系。进一步, 我们从神经层面上阐述了早期应激对情绪调节相关脑区和神经环路的影响。未来研究应当注意控制无关变量, 进一步探究不同早期应激对于情绪调节的影响。 相似文献
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The Neural Basis of Implicit Attitudes 总被引:1,自引:0,他引:1
Damian Stanley Elizabeth Phelps Mahzarin Banaji 《Current directions in psychological science》2008,17(2):164-170
ABSTRACT— Evidence that human preferences, beliefs, and behavior are influenced by sources that are outside the reach of conscious awareness, control, intention, and self-reflection is incontrovertible. Recent advances in neuroscience have enabled researchers to investigate the neural basis of these implicit attitudes, particularly attitudes involving social groups. From this research, a model with three identified neural components related to the automatic activation and regulation of implicit attitudes is beginning to emerge. The amygdala is implicated in the automatic evaluation of socially relevant stimuli, while the anterior cingulate and dorsolateral prefrontal cortices are involved in the detection and regulation, respectively, of implicit attitudes. Further support for this model comes from the inclusion of these regions in current models concerning the cognitive regulation of emotion and the detection of conflict. The identification of a putative neural substrate for implicit attitudes has had a direct impact on psychological research into their nature and operational characteristics. We discuss how this emerging neural model has influenced current research on implicit attitudes and describe the importance of such models for directing future research. 相似文献