移植免疫中微嵌合现象给我们的思考

随着移植免疫学研究的不断深入发展,诱导免疫耐受克服移植排斥反应已成为器官移植的主要研究目标。Starzl提出“双向移植排斥理论”并阐述临床使用免疫抑制药物下移植排斥反应的特点,突破了原有单向移植排斥理论的框架。“双向移植排斥理论”及理论内存在的问题给予我们众多有益的思考,在移植免疫学研究中,只有坚持用系统原则动态的看待事物间的联系与矛盾,进行科学实践,才能获得正确的理论,从而进一步推动移植免疫学的发展。     

从认知范式到人本范式 --创造性心理学研究范式的整体性转型

长期以来,认知范式创造性心理学将研究的重心放在个体创造性思维的发散性运演与转化上,排斥价值性研究。而人本范式创造性心理学将研究重心放在个体的人性建设上,从根本上实现了创造性心理学研究范式的整体性转型。本文对人本范式创造性心理学的哲学基础、主要观点、方法论思想、影响及局限作了简明扼要的阐释。     

Artificial intelligence for the measurement of vocal stereotypy

Both researchers and practitioners often rely on direct observation to measure and monitor behavior. When these behaviors are too complex or numerous to be measured in vivo, relying on direct observation using human observers increases the amount of resources required to conduct research and to monitor the effects of interventions in practice. To address this issue, we conducted a proof of concept examining whether artificial intelligence could measure vocal stereotypy in individuals with autism. More specifically, we used an artificial neural network with over 1,500 minutes of audio data from 8 different individuals to train and test models to measure vocal stereotypy. Our results showed that the artificial neural network performed adequately (i.e., session-by-session correlation near or above .80 with a human observer) in measuring engagement in vocal stereotypy for 6 of 8 participants. Additional research is needed to further improve the generalizability of the approach.     

The examination of factors influencing the recognition of affective states associated with tennis players’ non-verbal behaviour

In tennis, the non-verbal behaviours shown after a rally may indicate the affective state of players. The purpose of the present study was to assess whether (a) the point outcome, (b) the duration of video-excerpts, and (c) the tennis expertise of the participants would influence the recognition rates of the affective state. To that end, 115 participants were shown non-verbal behaviour of tennis players after a point and asked to rate whether the player had just won or lost a point. The results indicate that the recognition rates were higher for lost than for won points. Moreover, participants who were members of a tennis club had a higher recognition rate. Finally, there was no difference in the recognition rate regarding the duration of video excerpts. The findings point to a negativity bias and the bio-cultural framework in relation to the recognition of affective states associated with non-verbal behaviour.     

The Destiny of Creation: Theological Ethical Reflections on Laudato Si'

In this essay, I ask what the precise relation is between Laudato si's theology and its claims about our individual and corporate responsibility for the environment and the plight of the poor. To do so, I first clarify the relationship between the theological claims and its account of moral norms, situating the text within the history of western ethical theory. I then turn to reconstruct the submerged theology of the encyclical, focusing on Pope Francis's accounts of the techno‐economic paradigm and the possibility of an “integral ecology” paradigm. I end by assessing the text in terms of the coherence and plausibility of its argument as an ethical and theological statement.     

Finding Empathy: How Neuroscientific Measures,Evidence and Conceptualizations Interact

ABSTRACT

Questions about how empathy should be conceptualized have long been a preoccupation of the field of empathy research. There are numerous definitions of empathy that have been proposed and that often overlap with other concepts such as sympathy and compassion. This makes communication between research groups or across disciplines difficult. Many researchers seem to see the diversity of definitions as a problem rather than a form of benign pluralism. Within this debate about conceptualization, researchers sometimes suggest that more neuroscientific evidence will make the problem go away – that uncovering the processes underlying empathy will thereby also sort out conceptual difficulties. In this paper, I challenge this assumption by examining how neuroscientists studying empathy use concepts in practice – both in the development of their measures and in the interpretation of their data. I argue that this neuroscientific literature demonstrates that continuity and stability comes from the use of certain established measures, while progress comes from expansion upon those measures and the flexibility of stated concepts. We do not ‘find’ empathy through increased neuroscientific evidence but we do get closer to understanding empathic processes, flexibly understood.     

Reliability and validity of measures of anger/hostility in singapore: Cook & Medley Ho Scale, STAXI and Buss-Durkee hostility inventory

As part of a larger research programme concerned with the role of anger/hostility in heart disease in Singapore, three commonly used measures of anger/hostility (Cook & Medley Ho Scale, STAXI, Buss-Durkee Hostility Inventory) were examined for reliability and validity in an Asian population. A total of 968 Singaporean Chinese, Malay and Indian respondents completed one or more of these measures together with measures of symptom and illness experience. In addition, blood pressure and heart rate measures were taken for 201 respondents. Overall, the Ho and STAXI measures had reasonably high internal consistency and test-retest reliability. Internal consistency and test-retest reliability for the Buss Durkee measure were high for the total score but variable for the component scales. Correlation and regression showed that the Ho and STAXI appeared to be tapping a common core of variance, which can be characterized as trait anger. Correlations of the Ho and STAXI with health measures produced modest but statistically significant correlations for measures of symptom and illness experience and generally low and non-significant correlations for heart rate and blood pressure.     

Examining Individual Differences in Interpersonal Influence: On the Psychometric Properties of the Generalized Opinion Leadership Scale (GOLS)

Opinion leadership describes an individual's tendency to informally influence others’ attitudes and overt behaviors. In contrast to contemporary views of opinion leadership as a highly domain-specific trait, this paper introduces a multi-faceted personality trait, generalized opinion leadership (GOL) that characterizes exceptionally influential individuals independent of a specific subject area. Two studies report on the psychometric properties of a scale to assess GOL. Study 1 is based on three independent samples (N = 1,575, N = 1,275, and N = 231) and demonstrates the factorial structure of the instrument and its measurement invariance across sex, age, and educational levels. Study 2 (N = 310) analyzes multitrait-multiinformant data to highlight the scale's discriminant validity with regard to innovativeness and trendsetting.     

Exceptionalism or Chinamerica: Measuring Religious Change in the Globalizing World Today

Religion is changing fast in this era of globalization. Major global trends include the growth of Muslims, the shrinking percentage of unaffiliated, and the rapid rise of Christianity in global China. By 2030, China is likely to become the largest Christian country in the world while retaining large numbers of Buddhists, Muslims, and folk religious believers. To capture religious changes more accurately, social scientists of religion must sharpen their measurement tools regarding religiosity; pay more attention to the reality of nonalignment among religious identity, belief, and practice; and acknowledge the reality of nonexclusive/multiple religious beliefs, practices, and identities. Scholars must also take responsibility for developing a clear and nuanced definition of religion, abandon exceptionalist thinking, and seek to discover common patterns of religious change across societies. Conceptual and measurement tools at the disposal of social scientists of religion should enable us to perceive and understand the converging changes of religion in China, the United States, and other societies, without ignoring their historical differences and contemporary particularities.