从不规范联合用药转变为单药治疗过程分析抗癫痫药物的选择策略

单药治疗或合理的联合用药是癫痫治疗的重要原则,本文运用抗癫痫药物的药代动力学知识,分析了1例复杂不规范的联合用药导致治疗失败的原因,系统讲解了将其转变为有效的传统或新型抗癫痫药物单药治疗的理论和实践过程,并以此展示抗癫痫药物的选择策略。     

儿童缺血性脑病的诊治策略

结合国内外文献资料,从儿童缺血性脑病的病因、临床表现、影像学特点、治疗方式及疗效等方面着手,进行分析和比较,加深医患对儿童缺血性脑病的了解,同时为该类疾病的临床诊断与治疗思路提供借鉴。     

克服肿瘤干细胞耐药性的策略和思路

肿瘤干细胞（cancersterncells,CSCs）是肿瘤细胞的祖细胞。已有的研究表明,肿瘤干细胞对多种化疗药物具有耐药性,是导致肿瘤治疗后复发的根源。研究针对肿瘤干细胞的治疗方法,克服肿瘤干细胞耐药性,将给肿瘤治疗模式带来全新的改变,有望彻底改善肿瘤患者的预后。     

《乾》卦爻辞与周文王克商方略

《乾》卦爻辞的思想与周文王克商的整体战略有许多契合之处,如:“潜龙勿用”,与文王根据实力采取战略守势;“见龙在田”,与文王对西土方国的团结怀柔;“夕惕若厉”,与文王小心翼翼地臣事段商王朝;“或跃在渊”,与文王对大邑商发动战略进攻;“飞龙在天”,与文王谋划灭商的战略决战;“亢龙有悔”,与文王认识到攻取之道不可久用;“群龙无首”,与文王设计从武功向文治的战略转移等,皆有相通相合的地方.《乾》卦爻辞与文王克商方略之间的诸多契合表明,殷周之际王朝更迭的沧桑巨变,深刻地影响了《乾》卦爻辞的撰作.其中,文王克商的方略及其过程,应是《乾》卦最为重要的思想渊源之一.     

巴蜀易学源流考

巴蜀易学素有渊源,两汉为滥觞期,六朝为续传期.唐代为总结期,两宋为高峰期,元明以下则为流衍期.自两汉迄清末,历代巴蜀易学著作约有180余种;数量虽然不多,然特征却很鲜明,流派众多,“四道”毕备,其“尚辞”者则有苏轼之《苏氏易传》,“尚象”“尚变”者则有李鼎柞之《集解》、来知德之《集注》,其“尚占”者则如汉严遵,而尤以卜筮易、道家易源远流长.至于《易》《老》兼治者,则有严遵、扬雄;发明图书易者,则如陈抟、胡世安;其以佛陀解《易》者,则有苏轼、龙昌期.至于仿圣拟经,由扬雄开其先(撰《太玄》),而王长文(攫《通玄经》)、卫元嵩(《元苞》)诸人继其事,成为巴蜀易学之一大特色.后之治《易》《玄》,谈《图》《书》者,皆以蜀学发其轫.刘成炘曰:“易学在蜀(伊川语),如诗之有唐矣.”(《蜀学论》)信然.     

内隐学习策略的存在及其外显转化

该研究采用＂乘法算式答案正误判断的实验室任务＂,以＂奇偶检查策略＂为具体策略研究对象,探查内隐奇偶检查策略的存在及其自动性特征。实验结果表明：（1）奇偶检查策略可以以内隐方式存在,但经过不断练习可最终上升到意识层面;（2）奇偶检查策略的外显和内隐使用表现出各自独立的优势效应。外显学习策略的优势效应主要表现在正确算式判断任务中,而内隐学习策略则在错误算式判断任务中表现出＂内隐优势效应＂的趋势;（3）内隐奇偶检查策略的人为外显化并不能促使个体增加使用该策略的频率,也不能有效提高策略的执行效率。     

小学傣汉双语者汉语词汇形音的语义通达特点

采用语义启动研究范式,探讨傣族小学2、4、6年级汉语词汇和语音的语义通达特点。结果表明：1）对图片语义的提取存在学习年龄效应,2年级的反应时显著长于4、6年级;2）汉语词汇和语音都能显著促进图片语义的提取,但语音促进作用更明显;3）汉语词汇对图片语义提取的促进作用随年级的升高而增加,汉语语音的促进作用随年级的升高而减少。     

Unconscious transfer of meaning to brands

We examine semantic conditioning in a consumer context. We subliminally paired neutral ideographs with attributes. In experiment 1, the ideographs served as primes during a lexical decision task and slowed down response times to target words with the opposite semantic meaning. In experiment 2, the ideographs served as brand names of beverages, and attitudinal responses to them were less favorable when the associated attributes were incongruent with existing schemas. These results showed that semantic conditioning (1) can occur unconsciously, (2) can have significant and meaningful consequences for brand evaluation, and (3) influences subsequent attitudinal responses via conceptual disfluency processes.     

Attentional orienting and awareness: evidence from a discrimination task

We used several cue–target SOAs (100, 500, 1000 ms) and three different degrees of cue predictability (Non-predictive-50%, Predictive-75%, Counter-predictive-25%), to investigate the role of awareness of cue–target predictability on cueing effects. A group of participants received instructions about the informative value of the cue, while another group did not receive such instructions. Participants were able to extract the predictive value of a spatially peripheral cue and use it to orient attention, whether or not specific instructions about the predictive value of the cue were given, and no matter their ability to correctly report it in a post-test questionnaire. In the non-predictive block, bad estimators who received no instructions showed regular cueing effects, while good estimators exhibited smaller and non-significant facilitatory effects at the short SOA and an absence of significant IOR at longer SOAs. However, for the instructions group, the pattern of results reversed.     

Unconscious structural knowledge of form-meaning connections

We investigated the implicit learning of a linguistically relevant variable (animacy) in a natural language context (namely, the relation of forms of determiners to semantics). Trial by trial subjective measures indicated that exposure to a form–animacy regularity led to unconscious knowledge of that regularity. Under the same conditions, people did not learn about another form–meaning regularity when a linguistically arbitrary variable was used instead of animacy (size relative to a dog). Implicit learning is constrained to acquire unconscious knowledge about features with high prior probabilities of being relevant in that domain.