肿瘤疫苗治疗肿瘤的前景

肿瘤疫苗的发展已经历了一个多世纪,20世纪50年代,人们开始了自体肿瘤疫苗的研究.使肿瘤疫苗(主动性免疫治疗)成为继手术、放疗、化疗之后的肿瘤治疗方法.肿瘤疫苗作为主动特异性免疫治疗,在临床中起到越来越重要的作用,人们开始尝试利用多种方法制备肿瘤疫苗并利用其促进机体免疫应答,从整体细胞,分子水平调控机体对肿瘤的免疫.目前肿瘤疫苗的研制已取得很大进展,给人类战胜肿瘤提供很大希望.     

维度改变卡片分类任务中的负启动效应及其发生的条件

为了探讨负启动效应在学前儿童规则灵活转换中的作用, 用几个不同负启动版本的维度改变卡片分类任务(DCCS)研究了DCCS中的负启动效应及其在3、4岁儿童中的发展。实验一验证了儿童在负启动版本DCCS任务中的年龄发展趋势, 发现与标准版本一样, 大多数3、4岁儿童都不能通过, 但随着年龄增长负启动会逐渐减少, 更多的儿童能够顺利通过任务。实验二考察了DCCS中负启动发生的条件, 发现在任务的转换前阶段, 无论分类规则间存在冲突还是目标卡片与测试卡片间无关维度值上存在冲突, 负启动都会发生, 由此揭示出能引起选择性注意和主动抑制的冲突是负启动发生的关键。实验三探讨了负启动时主动抑制发生的层面, 发现儿童主动抑制的并非是无关维度中一个或某几个特定的值, 而是整个无关的维度, 表明抑制发生在维度这一更抽象的上位水平上。说明由抑制而产生的负启动或许也应成为儿童认知灵活性发展中需要克服的一个问题。     

Do aggression and rule‐breaking have different interpersonal correlates? A study of antisocial behavior subtypes,negative affect,and hostile perceptions of others

There is mounting evidence that physical aggression and nonaggressive, rule‐breaking delinquency constitute two separable though correlated subtypes of antisocial behavior. Even so, it remains unclear whether these behavioral subtypes have meaningfully different interpersonal correlates, particularly as they are subsumed within the same broad domain of antisocial behavior. To evaluate this, we examined whether hostile perceptions of others (assessed via exposure to a series of neutral unknown faces) were linked to level and type of antisocial behavior aggression vs. rule‐breaking, and moreover, whether this association persisted even when also considering the common association with negative affect (as manipulated via written recollection of one's best and worst life experiences). Analyses revealed that aggression, but not rule‐breaking, was uniquely tied to hostile perceptions of others. Furthermore, this association persisted over and above the common association of both hostile perceptions and aggression with negative affect (at both trait and state levels). Such results provide additional support for clinically meaningful differences between the behavioral subtypes of aggression and nonaggressive rule‐breaking and for the independent role of hostile perceptions in aggressive behavior. Aggr. Behav. 35:453–461, 2009. © 2009 Wiley‐Liss, Inc.     

THE HISTORICAL CONNECTION BETWEEN THE GOLDEN RULE AND THE SECOND GREATEST LOVE COMMAND

The golden rule, perhaps the most recognizable moral maxim in Western culture, is an inadequate basis for morality. In light of its flaws as a precept and its apparent lack of moral content, it is initially perplexing that the historic Judeo‐Christian tradition has often linked the golden rule with the second greatest command to love one's neighbor as oneself. However, after examining the presuppositions behind this link and investigating the biblical context of these sayings, it is clear that the Judeo‐Christian tradition is justified in making this connection. Although the golden rule and the love command should not be conflated and their distinctions should not be abandoned, the biblical intention of the golden rule can only be understood and properly practiced in connection with the love command.     

How to bring the news … peak-end effects in children’s affective responses to peer assessments of their social behavior

The retrospective evaluation of an event tends to be based on how the experience felt during the most intense moment and the last moment. Two experiments tested whether this so-called peak-end effect influences how primary school students are affected by peer assessments. In both experiments, children (ages 7–12) assessed two classmates on their behaviour in school and then received two manipulated assessments. In Experiment 1 (N ?=?30), one assessment consisted of four negative ratings and the other of four negative ratings with an extra moderately negative rating added to the end. In Experiment 2 (N ?=?44), one assessment consisted of four positive ratings, and the other added an extra moderately positive rating to the end. Consistent with the peak-end effect, the extended assessment in Experiment 1 and the short assessment in Experiment 2 were remembered as more pleasant and less difficult to deal with, which shaped children’s peer assessment preferences and prospective choices of which assessment to repeat. These findings indicate that the process of peer assessment can be improved by ending the feedback with the most positive part of the assessment.     

Production of Stress Retraction by Left- and Right-Hemisphere-Damaged Patients

An acoustic-perceptual investigation of a phonological phenomenon in which stress is retracted in double-stressed words (e.g., thirTEEN vs THIRteen MEN) was undertaken to identify the locus of functional impairments in speech prosody. Subjects included left-hemisphere-damaged (LHD) and right-hemisphere-damaged (RHD) patients and nonneurological controls. They were instructed to read sentences containing double-stressed target words in the presence of a clause boundary or its absence. Whereas all three groups of subjects were capable of manipulating the acoustic parameters that signal a shift in stress, there were some differences between the performance of the patient groups and that of the normal controls. Further, stress production deficits were more severe in LHD aphasic patients than in RHD patients. LHD speakers exhibited deficits in the control of both temporal and F0 cues. Their F0 disturbance appears to be secondary to a primary deficit in temporal control at the phase or sentence level, as an increased number of continuation rises found for the LHD patients seemed to arise from lengthy pauses within sentences. Findings are highlighted to address the nature of breakdown in speech prosody and the competing views of prosodic lateralization.     

汉语声调远距离规则的内隐学习及其迁移效应

内隐学习研究领域的一个重要问题是内隐学习获得的知识究竟是什么,即内隐学习获得的知识究竟是底层的抽象规则还是表面的特征.研究以汉语声调的远距离水平映射这一远距离规则为材料,通过对表面特征和底层规则之间的分离操作,在控制组块和重复结构等表面特征的条件下,探讨声调远距离规则的习得和迁移,结果发现被试能够内隐地习得和迁移汉语平仄声调的水平映射规则,证实了内隐学习确实能够获得底层的抽象规则,为内隐学习的抽象性问题提供了新的证据.