Conflicts of interest in science and medicine: the physician's perspective

The various statements and declarations of the World Medical Association that address conflicts of interest on the part of physicians as (1) researchers, and (2) practitioners, are examined, with particular reference to the October 2000 revision of the Declaration of Helsinki. Recent contributions to the literature, notably on conflicts of interest in medical research, are noted. Finally, key provisions of the American Medical Association’s Code of Medical Ethics (2000–2001 Edition) that address the various forms of conflict of interest that can arise in the practice of medicine are outlined. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002. The World Medical Association (WMA) is a global federation of National Medical Associations representing the millions of physicians worldwide. Acting on behalf of patients and physicians, the WMA endeavours to achieve the highest possible standards of medical care, ethics, education and health-related human rights for all people.     

Barbour's Fourfold Way: Problems with His Taxonomy of Science-religion Relationships

In this paper several problems are raised concerning Ian Barbour's four ways of interrelating science and religion—Conflict, Independence, Dialogue, and Integration—as put forward in such publications as his highly influential Religion in an Age of Science (1990) and widely adopted by other writers in this field. The authors argue that this taxonomy is not very useful or analytically helpful, especially to historians seeking to understand past engagements between science and religion.     

文本信息的激活与整合：阅读优生与差生的比较

探讨阅读优生与差生文本阅读过程中文本信息的激活与整合模式,包括3个实验。实验一通过运用不一致实验范式（inconsistent paradigm）考察阅读优生与阅读差生能否形成整体连贯性与局部连贯性。结果发现,阅读差生难以形成整体连贯性。实验二运用探测－核证范式（probe-verification paradigm）通过比较在三个位置后（人物特征描述、填充段落、目标句）的探测句的反应时间,探讨阅读差生不能形成整体连贯性的原因是由于不能激活先前的信息,还是整合信息时出现了问题。结果发现阅读差生与优生一样都可以激活先前的信息,说明阅读差生不能形成整体连贯性的原因可能是整合的问题。实验三进一步验证了阅读差生不能形成整体连贯性的原因是由于不能把已经激活的信息很好地加以整合所致。     

Rule following and rule use in the balance-scale task

Quinlan et al. [Quinlan, p., van der Mass, H., Jansen, B., Booij, O., & Rendell, M. (this issue). Re-thinking stages of cognitive development: An appraisal of connectionist models of the balance scale task. Cognition, doi:10.1016/j.cognition.2006.02.004] use Latent Class Analysis (LCA) to criticize a connectionist model of development on the balance-scale task, arguing that LCA shows that this model fails to capture a torque rule and exhibits rules that children do not. In this rejoinder we focus on the latter problem, noting the tendency of LCA to find small, unreliable, and difficult-to-interpret classes. This tendency is documented in network and synthetic simulations and in psychological research, and statistical reasons for finding such unreliable classes are discussed. We recommend that LCA should be used with care, and argue that its small and unreliable classes should be discounted. Further, we note that a preoccupation with diagnosing rules ignores important phenomena that rules do not account for. Finally, we conjecture that simple extensions of the network model should be able to achieve torque-rule performance.     

Comparing score tests and other local dependence diagnostics for the graded response model

Score tests for identifying locally dependent item pairs have been proposed for binary item response models. In this article, both the bifactor and the threshold shift score tests are generalized to the graded response model. For the bifactor test, the generalization is straightforward; it adds one secondary dimension associated only with one pair of items. For the threshold shift test, however, multiple generalizations are possible: in particular, conditional, uniform, and linear shift tests are discussed in this article. Simulation studies show that all of the score tests have accurate Type I error rates given large enough samples, although their small‐sample behaviour is not as good as that of Pearson's Χ² and M₂ as proposed in other studies for the purpose of local dependence (LD) detection. All score tests have the highest power to detect the LD which is consistent with their parametric form, and in this case they are uniformly more powerful than Χ² and M₂; even wrongly specified score tests are more powerful than Χ² and M₂ in most conditions. An example using empirical data is provided for illustration.     

Independence and dependence in human causal reasoning

Causal graphical models (CGMs) are a popular formalism used to model human causal reasoning and learning. The key property of CGMs is the causal Markov condition, which stipulates patterns of independence and dependence among causally related variables. Five experiments found that while adult’s causal inferences exhibited aspects of veridical causal reasoning, they also exhibited a small but tenacious tendency to violate the Markov condition. They also failed to exhibit robust discounting in which the presence of one cause as an explanation of an effect makes the presence of another less likely. Instead, subjects often reasoned “associatively,” that is, assumed that the presence of one variable implied the presence of other, causally related variables, even those that were (according to the Markov condition) conditionally independent. This tendency was unaffected by manipulations (e.g., response deadlines) known to influence fast and intuitive reasoning processes, suggesting that an associative response to a causal reasoning question is sometimes the product of careful and deliberate thinking. That about 60% of the erroneous associative inferences were made by about a quarter of the subjects suggests the presence of substantial individual differences in this tendency. There was also evidence that inferences were influenced by subjects’ assumptions about factors that disable causal relations and their use of a conjunctive reasoning strategy. Theories that strive to provide high fidelity accounts of human causal reasoning will need to relax the independence constraints imposed by CGMs.     

Situating Standards in Practices: Multi Drug-Resistant Tuberculosis Treatment in India

Public health care needs to cope with a basic dilemma between providing standardized care within public programmes across entire and at times resource-constrained countries and adapting this care locally when responding to individual needs. This tension between standardization and local adaptation becomes particularly obvious for the prolonged and complicated treatment of multidrug-resistant tuberculosis (MDR-TB). Situated standardization, as introduced by Zuiderent-Jerak [2007a, 2007b] offers a way out of this dilemma. It helps to focus on how standards need to be situated in practice rather than viewing standardization and local adaptation as mutually exclusive practices. How do actors relate standardization and individual care in their practices of treating MDR-TB? Results from qualitative fieldwork at the first MDR-TB treatment sites of the Indian TB programme show that actors situate standards in a particular way. They assess the role of guidelines in a particular situation and on that basis recognize the core recommendations of guidelines or go beyond the guidelines. This allows actors to negotiate how standards should be situated and reconciles the dilemma between local adaptation and standardization. Having guidelines internalized, as is common for Indian TB control, bears both promises and pitfalls for engaging in standardization processes in a situated manner. The results contribute to science and technology study scholarship on guideline development. They highlight how actors coordinate the situating of standards and how this depends upon cultures of control. This illustrates the potential of qualitative studies on local adaptation for guideline developers by revealing existing practices of relating and negotiating local adaptation and standardization.     

题组反应理论及其在中学英语考试中的应用研究

题组作为众多测验中的一种常见题型,由于项目间存在一定程度的依赖性而违背了局部独立性假设,若用项目反应模型进行参数估计将会出现较大的偏差.题组反应理论将被试与题组的交互作用纳入到模型中,解决了项目间相依性的问题.笔者对题组反应理论的发展、基本原理及其相关研究进行了综述,并将其应用在中学英语考试中.与项目反应理论相对比,结果发现：（1）题组反应模型与项目反应模型在各参数估计值的相关系数较强,尤其是能力参数和难度参数;（2）在置信区间宽度的比较上,题组反应模型在各个参数上均窄于项目反应模型,即题组反应模型的估计精度优于项目反应模型.     

Testing day: The effects of processing bias induced by Navon stimuli on the strength of the Müller-Lyer illusion

Explanations for the cognitive basis of the Müller-Lyer illusion are still frustratingly mixed. To date, Day’s (1989) theory of perceptual compromise has received little empirical attention. In this study, we examine the merit of Day’s hypothesis for the Müller-Lyer illusion by biasing participants toward global or local visual processing through exposure to Navon (1977) stimuli, which are known to alter processing level preference for a short time. Participants (N = 306) were randomly allocated to global, local, or control conditions. Those in global or local conditions were exposed to Navon stimuli for 5 min and participants were required to report on the global or local stimulus features, respectively. Subsequently, participants completed a computerized Müller-Lyer experiment where they adjusted the length of a line to match an illusory-figure. The illusion was significantly stronger for participants with a global bias, and significantly weaker for those with a local bias, compared with the control condition. These findings provide empirical support for Day’s “conflicting cues” theory of perceptual compromise in the Müller-Lyer illusion.     

Absolute and relative pitch: Global versus local processing of chords

Absolute pitch (AP) is the ability to identify or produce notes without any reference note. An ongoing debate exists regarding the benefits or disadvantages of AP in processing music. One of the main issues in this context is whether the categorical perception of pitch in AP possessors may interfere in processing tasks requiring relative pitch (RP). Previous studies, focusing mainly on melodic and interval perception, have obtained inconsistent results. The aim of the present study was to examine the effect of AP and RP separately, using isolated chords. Seventy-three musicians were categorized into four groups of high and low AP and RP, and were tested on two tasks: identifying chord types (Task 1), and identifying a single note within a chord (Task 2). A main effect of RP on Task 1 and an interaction between AP and RP in reaction times were found. On Task 2 main effects of AP and RP, and an interaction were found, with highest performance in participants with both high AP and RP. Results suggest that AP and RP should be regarded as two different abilities, and that AP may slow down reaction times for tasks requiring global processing.