Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework

CRISPR germline editing therapies (CGETs) hold unprecedented potential to eradicate hereditary disorders. However, the prospect of altering the human germline has sparked a debate over the safety, efficacy, and morality of CGETs, triggering a funding moratorium by the NIH. There is an urgent need for practical paths for the evaluation of these capabilities. We propose a model regulatory framework for CGET research, clinical development, and distribution. Our model takes advantage of existing legal and regulatory institutions but adds elevated scrutiny at each stage of CGET development to accommodate the unique technical and ethical challenges posed by germline editing.     

Career decision-making profiles and career decision-making difficulties: A cross-cultural comparison among US,Israeli, and Chinese samples

Assessing individuals' career decision-making difficulties and career decision-making profile (style) allows counselors to help them make better career decisions. The present study focused on the associations between the Career Decision-Making Profiles (CDMP) questionnaire and the Career Decision-making Difficulties Questionnaire (CDDQ) in four large samples: American adults (N = 601), Israeli young adults (N = 623), American students (N = 915), and Chinese students (N = 929). The pattern of associations between the 12 CDMP dimensions and the 10 CDDQ scales was generally replicated across the four samples, and indicated that certain CDMP dimensions were associated with career decision-making difficulties. Additionally, in all four samples, the higher an individual's career decision-making adaptability, as derived from the CDMP, the fewer difficulties he or she encountered prior to and during the career decision-making process. However, a few unique patterns of associations between the CDMP and the CDDQ emerged in some samples.     

Development of Japanese version of the long‐term mating orientation scale (LTMO‐J)

The purpose of this study was to validate the 7‐item long‐term mating orientation scale (LTMO) as translated into Japanese. Two samples of Japanese adults (N = 2000; 50.0% male; Mage = 40.9 for the first survey; N = 300; 54.7% male; Mage = 42.4 for the second survey) completed a web‐based questionnaire, including the Japanese translation of the LTMO. The results showed that the psychometric properties of the Japanese LTMO scale were comparable to those of the original English version. The scale had adequate reliability based on Cronbach's α and McDonald's ω. Convergent validity was demonstrated by the correlation between the LTMO scores and related variables: human life history strategies, short‐term sociosexual orientation, attitude to infidelity, romantic attachment style, and so on. The translated scale provides a valid and reliable instrument in Japanese that measures human mating strategy.     

Experience and Life as Ever‐Present Constraints on Knowledge

This essay argues that acknowledging the existence of mind‐independent facts is a matter of vital importance, in that acquiescence before the layout of the world is something demanded of knowing agents from the most elementary empirical deliverance to the most abstract construct. Building on the idea that normativity requires the presence of more than one option to choose from, the essay shows how the cessation of one's life is the disjunctive alternative of any experiential episode. This much has been missed, it argues, because of a generalized failure to appreciate how even the simplest atomic contents embroil their subjects in acts of assent. Its account thus casts a new light on relativism and skepticism, revealing them to be provisional luxuries supported only by the cognitive labor of others.     

An Examination of the Personality Constructs Underlying Dimensions of Creative Problem‐Solving Style

This study investigated the personality facets that underpin the construct of problem‐solving style, particularly when approaching more creative kinds of problem‐solving. Cattell's Sixteen Personality Factors Questionnaire and VIEW—An Assessment of Problem Solving Style were administered to 165 students from the Norwegian Business School. We explored relationships through correlational and regression analysis. Personality profiles were derived for each of VIEW's three dimensions and were in generally expected directions. Those with an Explorer preference were more imaginative and idea oriented, open to change, unconventional, freethinking, and flexible than Developers. Those with a Developer preference were more practical and solution oriented, more traditional, rule conscious, conservative, and respecting of traditional ideas. Those with an External preference were more group oriented, affiliative, socially bold, warm, and attentive to others than those with an Internal preference. Those with a more Task‐oriented preference were more impersonal, detached, utilitarian, and tough minded than those with Person‐oriented preference. We outlined implications and suggestions for further research.     

The Symptom as Ally,not Enemy

The practice of the Western medicine often identifies the symptom with the disease itself, but a current of thought and medical practice considers it as the important message of an organic imbalance. In fact, in standard therapies symptoms are usually suppressed, thus interrupting a normal physiological process and risking severe reactions due to the organic imbalance. Dr. Hahnemann, the father of homeopathy, founded his diagnostic and therapeutic model on the interpretation of the symptoms and maintained that symptoms are an expression of altered physiology. The same concept is to be found in Dr. Reckeweg's “reactivity” and homotoxicology; he believed that diseases are the expression of the struggle of the body against toxins. Reckeweg's contribution was particularly important in considering the inflammation process as a biologic process through which the body restores its health. Also PNEI (psycho-neuro-endocrino-immunology) proposes a model where the symptom is interpreted as information and as the result of an imbalance. Several other medical approaches address particular attention to the meaning of symptoms. The Bach Flower Therapy, for instance, is guided exclusively by the negative moods, which can become the cause of functional and organic diseases; balance is restored thanks to superior harmonic energetic vibrations conveyed by the superior energy living in some flowers. This interpretation of the nature of symptoms is becoming a more and more relevant issue among both the specialistic and the general public.     

Well-being on campus: testing the effectiveness of an online strengths-based intervention for first year college students

The present research examined the effectiveness of an 8-week online strengths-based intervention in promoting subjective and psychological well-being of first year university students. The intervention was composed of five modules pertaining to (a) finding and cultivating on character strengths, (b) regulation of emotions and increasing positive emotions, (c) constructive communication, establishing social connectedness and positive relationships (d) effective decision-making and problem solving and (e) achieving flow and practicing gratitude. A total 92 students volunteered to participate in the study. They were randomly assigned to either the intervention or a control group. Students’ quality of life (psychological health and social relations domains), life satisfaction, subjective happiness and ontological well-being were measured before and after the intervention. Significant improvements in well-being of intervention group participants were observed over an 8-week period whereas control group participants did not show a significant increase in any of these well-being variables.     

THE MODERN INVENTION OF “SCIENCE‐AND‐RELIGION”: WHAT FOLLOWS?

I am grateful to the four reviewers of The Territories of Science and Religion for their careful and insightful readings of the book, and their kind words about it. They all got the central arguments pretty much right, and thus any critical comments are not the result of fundamental misunderstandings. While there are some common themes in the assessments, each reviewer, happily, has offered a distinct perspective on the book. For this reason I will deal with their comments in turn, but with a focus throughout on a generally expressed concern about the broader implications of the book's historical analysis, and what positive or concrete proposals might follow from it.     

The role of body mass index,weight change desires and depressive symptoms in the health-related quality of life of children living in urban disadvantage: Testing mediation models

Objectives: This study was undertaken to ascertain whether or not the body mass index (BMI) of urban disadvantaged children indirectly affects their health-related quality of life (HRQoL) through weight change desires and depressive symptoms and whether such mediation is conditional upon age and gender.

Design: A total of 255 children aged 7–12 years (50% male) were recruited from 7 schools in urban disadvantaged districts in Ireland using consecutive sampling. A prospective longitudinal design was employed whereby children completed, at two time points, the Kidscreen-27, the Children’s Depression Inventory, and the Health Related Behaviour Questionnaire, and had their BMI measured. The analyses involved multiple-, half-longitudinal- and moderated-mediation.

Results: Results showed that the depressive symptoms of children wanting to change their weight may have lead, in large part, to poorer HRQoL (specifically psychological well-being when considering longitudinal data) rather than weight status per se. The mediation effect of weight change desires occurred regardless of age or gender.

Conclusions: Childhood obesity programmes that traditionally focus on the negatives of obesity and the need to control weight may need to take a more positive approach to health and well-being by, for example promoting intuitive eating, an active lifestyle, body acceptance and good mental health.     

Caregiving in multiple sclerosis and quality of life: A meta-synthesis of qualitative research

Objective: The lack of adequate conceptualisation and operationalisation of quality of life (QoL) limits the ability to have a consistent body of evidence to improve QoL research and practice in informal caregiving for people with multiple sclerosis (MS). Thus, we conducted a meta-synthesis of qualitative research to improve the conceptual understanding of the experiences of MS carers and to identify factors that affect carers’ QoL.

Design: Systematic searches of five electronic databases yielded 17 qualitative studies which were synthesised using the principles of meta-ethnography.

Results: The synthesis resulted in nine inter-linking themes: Changes and losses; challenges revolving around MS; caregiving demands; burden of care; future concerns; external stressors; experiences of support; strategies used in managing the caregiving role; and motivating factors. Our findings suggest that MS carers can have both positive and negative experiences which may bring challenges and rewards to the carers.

Conclusion: We present a proposed QoL model for MS caregiving which can be used to inform the development of interventions for MS carers to improve their QoL. However, further empirical research is needed to examine the utility of this model and to explore the concept of QoL in MS carers in more detail.