浅析生命质量在药物评价中的作用

随着医学模式的转变及心身医学的发展,近年来,生命质量的评定已成为一些药物评价的重要指标。由于生命质量的评定较好地反映了药物对患者身体、情感、社会心理等方面的影响,从而能够较为全面地评价药物疗效,有助于有效地指导临床选择用药。本文阐述了生命质量的定义,在药物评价中应考虑其对生命质量的影响以及通过实例说明如何进行生命质量的评定     

Stressful Life Events: A Revision and Update of the Social Readjustment Rating Scale

The widely used and cited Social Readjustment Rating Scale developed by Holmes and Rahe (1967) was comprehensively revised and updated. The new instrument, containing 51 major life events, was administered to a national sample of 5000. Respondents were asked to rate the stressfulness of each life event on a 1–100 scale. Completed surveys were returned by 3122 individuals (62.4%). Responses were analyzed using repeated measures MANOVA and profile analysis. Major results included: (a) statistically and practically significant differences in mean ratings for the 51 life events; (b) five overlapping themes in the top 20 rated life events—death and dying, healthcare, crime and the criminal justice system, financial/economic issues, and family-related issues; and (c) an amazing level of agreement concerning perceived life event stressfulness, regardless of gender, age, or income level.     

On the Relation Between Job Characteristics and Depression: A Longitudinal Study

The current study assumes that workers actively influence the characteristics of their work environment. Not only will one's work environment (job characteristics) affect personal characteristics, such as feelings of depression; depression in turn is expected to affect the characteristics of one's work environment as well. Using a sample of 593 young Dutch workers, a longitudinal model relating feelings of depression and job characteristics to each other was tested using structural equation modeling. The results largely supported our expectations. Depressive workers were less likely to experience a job transition than non-depressive workers. If depressive workers did experience a job transition, work outcomes were less positive than for nondepressive workers. Thus, it appears that the relation between job characteristics and depression can be construed as a reciprocal relation. Implications and limitations of the study are discussed.     

双耳分听和补笔对立即回忆延迟回忆影响的实验研究

通过两个实验探讨集中注意和补笔练习对立即回忆、延迟回忆的影响。实验一以英语单词为学习材料,使用组间设计方法,实验组采用附加追随程序和补笔练习;控制组为自定学习方式。学习结果表明：在自由回忆英文单词、听写英文单词和中译英三个方面,实验组的学习成绩明显高于控制组;实验组的学习方式更有利于低分组学生的学习。实验二的学习方式与实验一相同,通过４次测试的回归分析发现,实验组的学习发展水平明显高于控制组。     

遗忘症患者外显与内隐记忆分离的实验研究：自由回忆与再认任务

采用WMS－CR和MMSE筛选了9名遗忘症患者,采用自由回忆和再认两项任务观察了他们及正常对照组的外显记忆。结果发现：遗忘症患者两项外显记忆任务操作呈分离现象,自由回忆任务操作明显受损,再认任务的操作尽管较对照组低,但与对照组差异未达显著性水平。推论;①外显记忆受患者损伤的颞叶或间脑结构调节。②再认任务至少包含两种性质不同的潜在加工过程,一种为意识性重组加工,另一种为无意识自动加工,两者相互独立地贡献再认任务的操作。正常人意识性重组加工的贡献占优势,掩盖了无意识的作用。遗忘症患者意识性重组加工损伤,无意识自动加工部分代偿作用。③先前研究未对遗忘症患者进行认知功能的筛选,患者对再认障碍可能源于其他认知功能障碍,而非记忆障碍之故。     

重点中学与普通中学学生非智力因素的比较研究

本研究分别对重点中学与普通中学初一、初三年级学生的非智力因素状况进行调查,结果表明初一年级学生的非智力因素水平在两类学校之间不存在差异,而初三年级学生的非智力因素水平在两类学校之间存在着显著性差异（Ｐ＜０．０５）。随着年龄的增长,重点中学与普通中学学生的非智力因素水平都有所发展,但重点中学的学生发展得更好。本研究表明学校的教育环境影响着学生非智力因素的发展。     

初中一,二年级学生的亲子冲突

本研究选取北京市两所普通中学１９２名初一和初二学生为被试,通过学生对８个方面亲子冲突的评价,探讨初中生亲子冲突的特点。研究发现,（１）初中生早期的亲子冲突处于较低水平;（２）与母亲的冲突多于与父亲的冲突,女生尤其如此;（３）多数亲子冲突随年级而增加;（４）在多数冲突上,男生与父母的冲突多于女生;（５）亲子冲突最多的三个方面为日常生活安排、学业和家务,而冲突最少的为隐私。     

Coping styles in adults with cystic fibrosis: implications for emotional and social quality of life

As life expectancy increases, interest has grown surrounding the factors that may influence quality of life (QOL) for people with cystic fibrosis (CF). The aim of the current study was to examine which specific coping styles were positively or negatively associated with social and emotional QOL in a CF sample. One hundred and twenty-two respondents aged 18 and over were recruited through an online support group. Respondents completed the ‘CF Questionnaire-Revised (CFQ-R)’ and the ‘Brief COPE’. The CFQ-R is a disease-specific instrument designed to measure the impact of CF on nine QOL domains and the Brief COPE is a 28 item questionnaire which assesses 14 coping scales. A multivariate regression model revealed that higher substance abuse and disengagement was associated with lower emotional QOL whereas greater use of religion, instrumental coping and acceptance was positively associated with emotional QOL. Active coping was linked to better social QOL and a negative association was reported between distraction coping with both emotional and social domains. Given the burden of CF, ascertaining which factors enhance or diminish emotion and social well-being is now an integral component of QOL research. The current findings may therefore have value in informing clinical interventions which aim to cater for the psychological needs of individuals with CF.     

Quality of life and mental health among women with ovarian cancer: examining the role of emotional and instrumental social support seeking

The purpose of the present study was to examine the role of emotional and instrumental social support seeking in the quality of life (QOL) and mental health of women with ovarian cancer. Participants were recruited through the Pennsylvania Cancer Registry, and one hundred women took part in a mail questionnaire that collected information on their demographics, medical status, social support seeking, QOL and mental health including anxiety, depression and stress. Hierarchical linear regression analyses were conducted to assess the influence of emotional and instrumental social support seeking on QOL and mental health. After controlling for remission status, greater emotional social support seeking was predictive of higher overall QOL, social/family QOL, functional QOL and lower depression scores. Instrumental social support seeking was not significant in the models. The results illustrate that social support seeking as a coping mechanism is an important consideration in the QOL and mental health of women with ovarian cancer. Future studies should examine the psychological and behavioral mediators of the relationship to further understand the QOL and mental health of women with ovarian cancer.