Fixed-interval responding under second-order schedules of food presentation or cocaine injection.

Squirrel monkeys operated a key under second-order schedules in which every tenth completion of a 5-minute fixed interval resulted in either presentation of food or intravenous injection of cocaine. When a 2-second light was presented at the completion of the component fixed-interval schedules, positively accelerated responding developed and was maintained in each component. Over a tenfold range of doses of cocaine(30 to 300 microgram/kg/injection) and amounts of food (0.75 to 7.5 g/presentation); the second-order schedule of cocaine injection maintained higher average rates of responding than the second-order schedule of food presentation. Substituting saline for cocaine or eliminating food presentation decreased average rates of responding. When no stimulus change occurred at the completion of the first nine component fixed-interval schedules, but the 2-second light and food presentation or cocaine injection still occurred after the tenth component, only low and relatively constant rates of responding were maintained in each component. Patterns of responding characteristic of 5-minute fixed-interval schedules were maintained by the 2-second light paired with either cocaine injection or food presentation, though the maximum frequency of cocaine injection or food presentation was less than once per 50 minutes.     

The effects of different component response requirements in multiple and concurrent schedules

Six pigeons were trained on multiple and concurrent schedules. The reinforcement rates were varied systematically (a) when lever pressing was required in one component and key pecking in the successive component; (b) when lever pressing was required in both multiple components; (c) when key pecking was required in both multiple components; and (d) when key pecking was required on one schedule and lever pressing was required on the concurrently-available schedule. Only the absolute level of responding was changed by different response requirements. Analyzed by the generalized matching law, performance under different response requirements resulted in a bias toward key pecking, and the measured response bias was the same in multiple and concurrent schedule arrangements. The bias in time measures obtained from concurrent schedule performance was reliably smaller than the obtained response biases. The sensitivity to reinforcement-rate changes was ordered: concurrent key-lever; multiple key-key; multiple lever-key; and, the least sensitive, multiple lever-lever. The results confirm that requirements of different topographical responses can be handled by the generalized matching law mainly in the bias parameter, but problems for this type of analysis may be caused by the changing sensitivity to reinforcement in multiple schedule performance as response requirements are changed.     

Simultaneous auditory discrimination.

Stimuli in many visual stimulus control studies typically are presented simultaneously; in contrast the stimuli in auditory discrimination studies are presented successively. Many everyday auditory stimuli that control responding occur simultaneously. This suggests that simultaneous auditory discriminations should be readily acquired. The purpose of the present experiment was to train rats in a simultaneous auditory discrimination. The apparatus consisted of a cage with two response levers mounted on one wall and a speaker mounted adjacent to each lever. A feeder was mounted on the opposite wall. In a go-right/go-left procedure, two stimuli were presented on each trial, a wide-band noise burst through one speaker and a 2-kHz complex signal through the other. The stimuli alternated randomly from side to side across trials, and the stimulus correlated with reinforcement for presses varied across subjects. The rats acquired the discrimination in 400 to 700 trials, and no response position preference developed during acquisition. The ease with which the simultaneous discrimination was acquired suggests that procedures, such as matching to sample, that require simultaneous presentation of stimuli can be used with auditory stimuli in animals having poor vision.     

Food and cocaine self-administration by baboons: effects of alternatives.

The effects of the availability of an alternative reinforcer on responding maintained by food pellets or drug solutions were examined in 8 adult male baboons (Papio hamadrayas anubis). During daily 23-hr experimental sessions, baboons had access to both food pellets and fluid under a two-choice procedure, in which the response requirement, under a fixed-ratio schedule, differed for the two commodities. There were no restrictions on access to water, which was continuously available from a spout at the rear of each cage. In Experiment 1, the fixed-ratio requirement, or cost, for fluid delivery remained constant while the fixed-ratio requirement for pellets was changed every 2 or 3 days when (a) no fluid, (b) a dilute dextrose vehicle, (c) 0.008 mg/kg per delivery cocaine, (d) 0.016 mg/kg per delivery cocaine, or (e) 0.032 mg/kg per delivery cocaine was available concurrently. In Experiment 1, progressively increasing the response requirement for pellets decreased pellet intake, but for 4 baboons pellet intake at maximum pellet cost was lower when cocaine, compared to the vehicle, was available. Increasing the response requirement for pellets had variable effects on vehicle intake. However, increasing the response requirement for pellets increased intake of at least one dose of cocaine to a greater extent than vehicle in all 8 baboons. Thus, cocaine could be considered a more effective economic substitute than vehicle for pellets. Experiment 2 systematically varied the order in which the response requirements for a pellet delivery were presented and added a control condition in which cocaine doses, yoked to the amount self-administered, were given three times during the session by the experimenter. Again, pellet intake at maximal pellet cost was lower when cocaine, compared to the vehicle, was available. In contrast, experimenter-given cocaine doses did not alter responding maintained by pellets. Thus, the effects of self-administered cocaine on responding maintained by food pellets differed from the effects of experimenter-given cocaine on responding maintained by food pellets.     

EFFECT OF REINFORCER MAGNITUDE ON PERFORMANCE MAINTAINED BY PROGRESSIVE‐RATIO SCHEDULES

This experiment examined the relationship between reinforcer magnitude and quantitative measures of performance on progressive‐ratio schedules. Fifteen rats were trained under a progressive‐ratio schedule in seven phases of the experiment in which the volume of a 0.6‐M sucrose solution reinforcer was varied within the range 6–300 μl. Overall response rates in successive ratios conformed to a bitonic equation derived from Killeen's (1994) Mathematical Principles of Reinforcement. The “specific activation” parameter, a, which is presumed to reflect the incentive value of the reinforcer, was a monotonically increasing function of reinforcer volume; the “response time” parameter, δ, which defines the minimum response time, increased as a function of reinforcer volume; the “currency” parameter, b, which is presumed to reflect the coupling of responses to the reinforcer, declined as a function of volume. Running response rate (response rate calculated after exclusion of the postreinforcement pause) decayed monotonically as a function of ratio size; the index of curvature of this function increased as a function of reinforcer volume. Postreinforcement pause increased as a function of ratio size. Estimates of a derived from overall response rates and postreinforcement pauses showed a modest positive correlation across conditions and between animals. Implications of the results for the quantification of reinforcer value and for the use of progressive‐ratio schedules in behavioral neuroscience are discussed.     

Within-session Changes In Responding During Concurrent Variable-interval Schedules

Five rats and 4 pigeons responded for food delivered by several concurrent variable-interval schedules. The sum of the rates of reinforcement programmed for the two components varied from 15 to 480 reinforcers per hour in different conditions. Rates of responding usually changed within the experimental session in a similar manner for the two components of each concurrent schedule. The within-session changes were similar to previously reported changes during simple schedules that provided rates of reinforcement equal to the sum of all reinforcers obtained from the concurrent schedules. The number of changeovers also changed within sessions in a manner similar to the changes in instrumental responding. These results suggest that changeovers are governed by the same variables that govern instrumental responding. They also suggest that the within-session change in responding during each component of a concurrent schedule is determined by approximately the sum of the reinforcers obtained from both components when both components provide the same type of reinforcer.     

Tolerance to and residual effects of cocaine in squirrel monkeys depend on reinforcement-schedule parameter.

Lever pressing by 4 squirrel monkeys was maintained under a three-component multiple fixed-ratio schedule of food presentation; components differed with respect to ratio size. For each monkey, acute administration of cocaine (0.03 to 1.3 mg/kg, i.m.) produced dose-dependent decreases in overall response rate in each component. During repeated daily administration of 1.0 mg/kg of cocaine, tolerance developed to the rate-decreasing effects under each of the ratio contingencies, but developed to a greater extent and was evident in earlier parts of sessions for performance under the smaller ratios. Response rates of 2 monkeys increased above nondrug control levels despite the putative reinforcer not being consumed during the session. When saline or a smaller dose of cocaine was substituted for 1.0 mg/kg, response rates often were suppressed below nondrug control-level responding. This suppressive effect was observed in each monkey and was more likely to be observed and/or to be of greater magnitude in large-ratio components for 3 of the 4 monkeys. When saline was administered chronically at the end of the chronic-drug phase, response rates remained suppressed in the large-ratio component for 2 of the monkeys. There was, therefore, a schedule-dependent dissociation between behavioral tolerance and the residual effects: Tolerance was greater when small ratios were arranged, whereas the residual effects were more pronounced when larger ratios were arranged.     

Schedule-induced defecation by rats during ratio and interval schedules of food reinforcement.

Lever pressing in rats was maintained by continuous and intermittent schedules of food while defecation was monitored. In Experiment 1, reinforcement densities were matched across variable-ratio and variable-interval schedules for three pairs of rats. Defecation occurred in all 3 rats on the variable-ratio schedule and in all 3 rats on the yoked variable-interval schedule. In Experiment 2, fixed-ratio and fixed-interval schedules with similar reinforcement densities maintained lever pressing. Defecation occurred in 3 of 4 rats on the fixed-ratio schedule and in 4 of 4 rats on the fixed-interval schedule. Almost no defecation occurred during continuous reinforcement in either experiment. These results demonstrate that defecation may occur during both ratio and interval schedules and that the inter-reinforcement interval is more important than the behavioral requirements of the schedule in generating schedule-induced defecation.     

The long-term effect of high- and low-rate responding histories on fixed-interval responding in rats

Tell rats were given extended lever-press training on a fixed-interval (FI) 30-s food reinforcement schedule from the outset or following exposure to one or two previous reinforcement schedules. For 4 rats the previots schedule was either fixed-ratio 20, which generated high response rates, or differential-reinforcement-of-low-rate 20 s, which produced low response rates. For 4 additional rats the extended training on FI 30 s was preceded by experience with two schedules: fixed-ratio 20 followed by differential-reinforcement-of-low-rate 20 s; or the same two schedules in the reverse order. Fixed-interval response rates were initially affected by the immediately preceding schedule, but after 80 to 100 sessions, all traces of prior schedule history had disappeared. The results also showed no long-term effect of schedule history on the interfood-interval patterns of responding on the FI 30-s schedule. These results support one of the most central tenets of the experimental analysis of behavior: control by the immediate consequences of behavior.     

Effects of reinforcement history on response rate and response pattern in periodic reinforcement

Several researchers have suggested that conditioning history may have long-term effects on fixed-interval performances of rats. To test this idea and to identify possible factors involved in temporal control development, groups of rats initially were exposed to different reinforcement schedules: continuous, fixed-time, and random-interval. Afterwards, half of the rats in each group were studied on a fixed-interval 30-s schedule of reinforcement and the other half on a fixed-interval 90-s schedule of reinforcement. No evidence of long-term effects attributable to conditioning history on either response output or response patterning was found; history effects were transitory. Different tendencies in trajectory across sessions were observed for measures of early and late responding within the interreinforcer interval, suggesting that temporal control is the result of two separate processes: one involved in response output and the other in time allocation of responding and not responding.