大脑视觉词形区及其在阅读神经网络中的作用

大脑梭状回中部被认为是视觉词形加工区(Visual Word Form Area, VWFA)。近年来的研究对VWFA的功能提出了质疑, 研究者开始关注VWFA作为复杂阅读网络的一部分与其它脑区的动态联结机制, 主要集中在三个方面：一是梭状回中部对于视觉词形选择性敏感的本质; 二是它在词汇阅读的神经网络中的作用; 最后是语言经验对于VWFA认知神经功能的塑造作用。结合以上研究的最新进展, 文中指明从动态神经网络的角度揭示大脑功能成为今后认知神经科学研究的最新取向。     

Religious Right,Religious Left,Both, or Neither? Understanding Religio‐Political Identification

In this article we analyze the effects of religious, political, socioeconomic, and demographic variables on religious Americans’ propensity to identify with religio‐political movements. Using data from the 2013 Economic Values Survey collected by the Public Religion Research Institute (PRRI), we sort nonsecular Americans into four categories: religious right, religious left, both religious right and religious left, or neither religious right nor the religious left. We estimate a multinomial logit model in which we depict religio‐political identification as a function of religious affiliation, worship attendance, religious embeddedness, religious convictions, political attitudes, and socioeconomic and demographic controls. We find that a wide range of religious, political, and socioeconomic/demographic variables affect individuals’ identification with the religious right and/or religious left. Our empirical results also permit us to analyze the seeming paradox of identifying with both the religious right and the religious left. We find that individuals who identify with both movements come from the ranks of the highly religious, those who believe that being moral requires one to believe in God, Tea Party supporters, strong partisans, those with lower education and income, older individuals, and blacks and Hispanics.     

TMS to the “occipital face area” affects recognition but not categorization of faces

The human cortical system for face perception is comprised of a network of connected regions including the middle fusiform gyrus (“fusiform face area” or FFA), the inferior occipital cortex (“occipital face area” or OFA), and the superior temporal sulcus. The traditional hierarchical feedforward model of visual processing suggests information flows from early visual cortex to the OFA for initial face feature analysis to higher order regions including the FFA for identity recognition. However, patient data suggest an alternative model. Patients with acquired prosopagnosia, an inability to visually recognize faces, have been documented with lesions to the OFA but who nevertheless show face-selective activation in the FFA. Moreover, their ability to categorize faces remains intact. This suggests that the FFA is not solely responsible for face recognition and the network is not strictly hierarchical, but may be organized in a reverse hierarchical fashion. We used transcranial magnetic stimulation (TMS) to temporarily disrupt processing in the OFA in neurologically-intact individuals and found participants’ ability to categorize intact versus scrambled faces was unaffected, however face identity discrimination was significantly impaired. This suggests that face categorization but not recognition can occur without the “earlier” OFA being online and indicates that “lower level” face category processing may be assumed by other intact face network regions such as the FFA. These results are consistent with the patient data and support a non-hierarchical, global-to-local model with re-entrant connections between the OFA and other face processing areas.     

A social neuroscience approach to self and social categorisation: A new look at an old issue

We take a social neuroscience approach to self and social categorisation in which the current self-categorisation(s) is constructed from relatively stable identity representations stored in memory (such as the significance of one's social identity) through iterative and interactive perceptual and evaluative processing. This approach describes these processes across multiple levels of analysis, linking the effects of self-categorisation and social identity on perception and evaluation to brain function. We review several studies showing that self-categorisation with an arbitrary group can override the effects of more visually salient, cross-cutting social categories on social perception and evaluation. The top-down influence of self-categorisation represents a powerful antecedent-focused strategy for suppressing racial bias without many of the limitations of a more response-focused strategy. Finally we discuss the implications of this approach for our understanding of social perception and evaluation and the neural substrates of these processes.     

错误相关负波的神经起源及其影响因素

与个体做出错误反应相伴的错误相关ERP成分叫错误相关负波 (error-related negativity, ERN),当前冲突监控理论、表征失匹配理论和强化学习理论从不同的角度对ERN的神经机制进行解释,各理论间并非完全相互排斥。目前大部分研究认为ERN定位于扣带回,部分研究则出现其它脑区的激活,然而,扣带回与其它脑区存在复杂的神经功能联系,ERN 电位很可能是多个脑区电活动在头颅的综合表现,而非某一脑区的单独表现。ERN的神经机制受到实验任务、被试年龄及其意识水平等因素的影响。未来要推动实验室研究走向临床应用,发现与诊断脑电波异常的病人和毒品易复吸人群。     

Brain lateralization of complex movement: Neuropsychological evidence from unilateral stroke

Complex movement (CM) refers to the representation of a goal-oriented action and is classified as either transitive (use of tools) or intransitive (communication gestures). Both types of CM have three specific components: temporal, spatial, and content, which are subdivided into specific error types (SET). Since there is debate regarding the contribution of each brain hemisphere for the types of CM, our objective was to describe the brain lateralization of components and SET of transitive and intransitive CM. We studied 14 patients with a left hemisphere stroke (LH), 12 patients with a right hemisphere stroke (RH), and 16 control subjects. The Florida Apraxia Screening Test-Revised (FAST-R, Rothi et al., 1988) was used for the assessment of CM. Both clinical groups showed a worse performance than the control group on the total FAST-R and transitive movement scores (p < 0.001). Failures in Spatial and Temporal components were found in both clinical groups, but only LH patients showed significantly more Content errors (p < 0.01) than the control group. Also, only the LH group showed a higher number of errors for intransitive movements score (p = 0.017), due to lower scores in the content component, compared to the control group (p = 0.04). Transitive and intransitive CMs differ in their neurocognitive representation; transitive CM shows a bilateral distribution of its components when compared to intransitive CM, which shows a preferential left hemisphere representation. This could result from higher neurocognitive demands for movements that require use of tools, compared with more automatic communication gestures.     

急性前壁心肌梗死患者直接PCI后阿托伐他汀不同用药剂量疗效比较

为探讨直接经皮冠状动脉介入治疗（PCI）首次急性前壁心肌梗死患者,在不同剂量他汀药物治疗后住院期间疗效比较,纳入首次诊断为急性前壁心肌梗死并接受直接PCI治疗的患者140例,随机分为强化治疗组和对照组。强化治疗组入院时顿服阿托伐他汀80mg,术后40mg／晚,直至出院;对照组口服阿托伐他汀20mg／晚。术前及术后、出院前测定心肌标记物,术前及出院前测定血浆氨基末端B型利钠肽前体（NT—proBNP）,采用彩色多普勒超声检测左室射血分数（LVEF）的变化,同时记录住院期间主要心脏不良事件（MACEs）的发生。结果出院时LVEF值差异无统计学意义（P=0．249）,NT—proBNP出院前较术前升高,对照组升高显著（P=0．000）。组间比较NT—proBNP,对照组显著高于强化组（P=0．020）。住院期间两组患者无MACEs发生。首次急性前壁心肌梗死患者直接PCI后,强化阿托伐他汀治疗短期内可改善左心功能。     

ECG诊断左室肥厚的临床价值

比较ECG的Sokolow-lyon标准和Cornell标准对诊断左室肥厚的敏感性和特异性,以评价其在高血压左室肥厚（Left Ventricular Hypertrophy,LVH）中的诊断价值。对188例高血压患者,根据超声心动图（Uhrasoniccardiogram,UCG）检查结果有无LVH分组,分别计算So...     

不同视觉区域OUP效应的眼动研究

摘 要 采用眼动方法,通过两个实验考察了不同视觉区域的OUP效应。结果显示：（1）当刺激材料分别平行呈现于左侧视觉区域和右侧视觉区域时,在右侧视觉区域产生了OUP效应,而在左侧视觉区域没有OUP效应,我们假设是由于左侧视觉区域首字母距离中央凹的不利位置影响了OUP效应的产生。（2）当垂直方向呈现刺激时,在两侧视觉区域均产生了明显的OUP效应,表明首字母距离中央凹处于有利位置时不会影响OUP效应的产生。实验结果支持了大脑左半球和右半球在词汇识别时的策略为系列加工,对左半球平行加工右半球系列加工的结论提出了质疑。     

BOLD response to motion verbs in left posterior middle temporal gyrus during story comprehension

A primary focus within neuroimaging research on language comprehension is on the distribution of semantic knowledge in the brain. Studies have shown that the left posterior middle temporal gyrus (LPMT), a region just anterior to area MT/V5, is important for the processing of complex action knowledge. It has also been found that motion verbs cause activation in LPMT. In this experiment we investigated whether this effect could be replicated in a setting resembling real life language comprehension, i.e. without any overt behavioral task during passive listening to a story. During fMRI participants listened to a recording of the story “The Ugly Duckling”. We incorporated a nuisance elimination regression approach for factoring out known nuisance variables both in terms of physiological noise, sound intensity, linguistic variables and emotional content. Compared to the remaining text, clauses containing motion verbs were accompanied by a robust activation of LPMT with no other significant effects, consistent with the hypothesis that this brain region is important for processing motion knowledge, even during naturalistic language comprehension conditions.