氟哌啶醇干扰决策过程中前扣带回神经元的放电活动

运用在体多通道神经元放电同步记录技术, 观察和记录大鼠在完成T-迷宫成本效益决策任务时前扣带回神经元放电和局部场电位的变化及氟哌啶醇对此的改变, 在细胞水平上探讨前扣带回在决策中的作用以及多巴胺递质系统对决策的作用机制。结果显示, 经过一段时间的训练, 10只大鼠中有8只偏好高付出-高奖赏端, 且在选择高付出-高奖赏端时的神经元放电频率要显著高于选择低付出-低奖赏端时的频率, 同时局部场电位也呈现出事件相关性; 腹腔注射多巴胺受体拮抗剂氟哌啶醇后, 大鼠不再偏好高付出-高奖赏端, 对该端的选择显著减少, 而对低付出-低奖赏端的选择显著增加, 且神经元的放电频率和局部场电位显著降低, 神经元放电和局部场电位的特征性也消失。研究提示, 前扣带回和多巴胺在努力相关决策任务中有着至关重要的作用。     

Religious Right,Religious Left,Both, or Neither? Understanding Religio‐Political Identification

In this article we analyze the effects of religious, political, socioeconomic, and demographic variables on religious Americans’ propensity to identify with religio‐political movements. Using data from the 2013 Economic Values Survey collected by the Public Religion Research Institute (PRRI), we sort nonsecular Americans into four categories: religious right, religious left, both religious right and religious left, or neither religious right nor the religious left. We estimate a multinomial logit model in which we depict religio‐political identification as a function of religious affiliation, worship attendance, religious embeddedness, religious convictions, political attitudes, and socioeconomic and demographic controls. We find that a wide range of religious, political, and socioeconomic/demographic variables affect individuals’ identification with the religious right and/or religious left. Our empirical results also permit us to analyze the seeming paradox of identifying with both the religious right and the religious left. We find that individuals who identify with both movements come from the ranks of the highly religious, those who believe that being moral requires one to believe in God, Tea Party supporters, strong partisans, those with lower education and income, older individuals, and blacks and Hispanics.     

赌博游戏中的near-miss效应

near-miss效应是指在赌博中, 与一般的输钱和赢钱相比, “几乎赢(near-miss)”的输钱会诱发个体更高的生理唤醒和更强的赌博动机, 从而导致个体持续赌博的一种现象, 是导致赌博成瘾的主要诱因之一。针对这种现象的研究范式大致有三种：老虎机/类老虎机任务、轮盘任务和刮刮乐彩票任务。这种现象的理论解释目前主要有认知曲解假说、控制幻觉理论和受挫假说。near-miss效应的脑机制和病理研究才刚刚起步, 所涉及到的脑功能区域主要包括脑岛、腹侧纹状体等。未来的研究应在near-miss效应发生机制的理论模型建构、研究范式多样化、研究技术多模态化、病理机制和临床干预等方面进一步展开。     

非球面人工晶状体临床应用的启示

非球面人工晶状体是波前像差技术与现代白内障手术完美结合的产物,也是多学科联合发展的结果。非球面人工晶状体较传统球面人工晶状体可明显改善白内障患者的视功能。倘若能实现个体化设计,非球面人工晶状体有望取代球面人工晶状体成为人工晶状体的主流。     

Attentional control in the aging brain: insights from an fMRI study of the stroop task

Several recent studies of aging and cognition have attributed decreases in the efficiency of working memory processes to possible declines in attentional control, the mechanism(s) by which the brain attempts to limit its processing to that of task-relevant information. Here we used fMRI measures of neural activity during performance of the color-word Stroop task to compare the neural substrates of attentional control in younger (ages: 21-27 years old) and older participants (ages: 60-75 years old) during conditions of both increased competition (incongruent and congruent neutral) and increased conflict (incongruent and congruent neutral). We found evidence of age-related decreases in the responsiveness of structures thought to support attentional control (e.g., dorsolateral prefrontal and parietal cortices), suggesting possible impairments in the implementation of attentional control in older participants. Consistent with this notion, older participants exhibited more extensive activation of ventral visual processing regions (i.e., temporal cortex) and anterior inferior prefrontal cortices, reflecting a decreased ability to inhibit the processing of task-irrelevant information. Also, the anterior cingulate cortex, a region involved in evaluatory processes at the level of response (e.g., detecting potential for error), showed age-related increases in its sensitivity to the presence of competing color information. These findings are discussed in terms of newly emerging models of attentional control in the human brain.     

Comprensión del lenguaje y potenciales evocados

Resumen

En este trabajo se pretende dar cuenta de los últimos adelantos en el campo de los procesos relacionados con la comprensión del lenguaje y los potenciales evocados. Estos han mostrado ser herramientas útiles para el estudio de dichos procesos. Para ello se revisan una serie de estudios relacionados con los componentes que clásicamente han venido recibiendo una mayor atención. Así, el Potencial de Reconocimiento y la N400, parecen guardar relación con aspectos semánticos. Por otro lado, la Negatividad Izquierda Anterior Temprana y la P600 estarían más relacionados con los sintácticos. También se mencionan otros componentes, como la P300 y algunos que ha recibido menor atención.     

Brain lateralization of complex movement: Neuropsychological evidence from unilateral stroke

Complex movement (CM) refers to the representation of a goal-oriented action and is classified as either transitive (use of tools) or intransitive (communication gestures). Both types of CM have three specific components: temporal, spatial, and content, which are subdivided into specific error types (SET). Since there is debate regarding the contribution of each brain hemisphere for the types of CM, our objective was to describe the brain lateralization of components and SET of transitive and intransitive CM. We studied 14 patients with a left hemisphere stroke (LH), 12 patients with a right hemisphere stroke (RH), and 16 control subjects. The Florida Apraxia Screening Test-Revised (FAST-R, Rothi et al., 1988) was used for the assessment of CM. Both clinical groups showed a worse performance than the control group on the total FAST-R and transitive movement scores (p < 0.001). Failures in Spatial and Temporal components were found in both clinical groups, but only LH patients showed significantly more Content errors (p < 0.01) than the control group. Also, only the LH group showed a higher number of errors for intransitive movements score (p = 0.017), due to lower scores in the content component, compared to the control group (p = 0.04). Transitive and intransitive CMs differ in their neurocognitive representation; transitive CM shows a bilateral distribution of its components when compared to intransitive CM, which shows a preferential left hemisphere representation. This could result from higher neurocognitive demands for movements that require use of tools, compared with more automatic communication gestures.     

急性前壁心肌梗死患者直接PCI后阿托伐他汀不同用药剂量疗效比较

为探讨直接经皮冠状动脉介入治疗（PCI）首次急性前壁心肌梗死患者,在不同剂量他汀药物治疗后住院期间疗效比较,纳入首次诊断为急性前壁心肌梗死并接受直接PCI治疗的患者140例,随机分为强化治疗组和对照组。强化治疗组入院时顿服阿托伐他汀80mg,术后40mg／晚,直至出院;对照组口服阿托伐他汀20mg／晚。术前及术后、出院前测定心肌标记物,术前及出院前测定血浆氨基末端B型利钠肽前体（NT—proBNP）,采用彩色多普勒超声检测左室射血分数（LVEF）的变化,同时记录住院期间主要心脏不良事件（MACEs）的发生。结果出院时LVEF值差异无统计学意义（P=0．249）,NT—proBNP出院前较术前升高,对照组升高显著（P=0．000）。组间比较NT—proBNP,对照组显著高于强化组（P=0．020）。住院期间两组患者无MACEs发生。首次急性前壁心肌梗死患者直接PCI后,强化阿托伐他汀治疗短期内可改善左心功能。     

一期颈椎后前路手术治疗伴有后凸畸形的多节段颈椎管狭窄的临床研究

为了研究与探讨一期颈椎后前路联合手术治疗伴有后凸畸形的多节段颈椎管狭窄的临床疗效,回顾性研究2011年3月至2013年2月在我院由同一组外科医生治疗且符合标准纳入研究的患者32例,比较术前与术后的 JOA 评分,颈髓功能改善率,Borden 氏测量法的 D 值,Vas 评分,评估一期颈椎后前路联合手术治疗该疾病的临床疗效。患者术后均随访12个月,患者接受一期后前路手术治疗后双臂双手麻木、间歇性跛行、走路有踩棉花感、肢体感觉障碍症状均有明显改善。一期颈椎后前路联合手术治疗伴有后凸畸形的多节段颈椎管狭窄症,可有效地矫正颈椎的后凸畸形,恢复颈椎正常的生理弯曲,解除颈髓压迫,恢复颈椎生理曲度,是安全有效的手术方法。     

ECG诊断左室肥厚的临床价值

比较ECG的Sokolow-lyon标准和Cornell标准对诊断左室肥厚的敏感性和特异性,以评价其在高血压左室肥厚（Left Ventricular Hypertrophy,LVH）中的诊断价值。对188例高血压患者,根据超声心动图（Uhrasoniccardiogram,UCG）检查结果有无LVH分组,分别计算So...