严重脓毒症——评价指标带给我们的启示

目前,严重脓毒症的诊断指标已对脓毒症导致的临床情况作出较好的诠释,进一步寻找相关的指标将更有助于临床判断。我们评价了血流动力学和组织灌注参数,免疫紊乱、凝血障碍的相关参数以及前降钙素等指标在临床上的价值。目前所采用的一些指标确实有助于严重脓毒症的诊断,但是,我们需要更特异的指标来指导临床工作。     

Overconfidence and underconfidence: When and why people underestimate (and overestimate) the competition

It is commonly held that people believe themselves to be better than others, especially for outcomes under their control. However, such overconfidence is not universal. This paper presents evidence showing that people believe that they are below average on skill-based tasks that are difficult. A simple Bayesian explanation can account for these effects and for their robustness: On skill-based tasks, people generally have better information about themselves than about others, so their beliefs about others’ performances tend to be more regressive (thus less extreme) than their beliefs about their own performances. This explanation is tested in two experiments that examine these effects’ robustness to experience, feedback, and market forces. The discussion explores the implications for strategic planning in general and entrepreneurial entry in particular.     

Not so above average after all: When people believe they are worse than average and its implications for theories of bias in social comparison

Recent research calls into question the generally accepted conclusion that people believe themselves to be better than average. This paper reviews the new theories that have been proposed to explain the fact that better-than-average effects are isolated to common behaviors and abilities, and that people believe themselves to be below average with respect to rare behaviors and uncommon abilities. These new theories are then used to revisit prior findings of better-than-average effects. When viewed in light of recent work, the evidence suggests that prior findings overstated the degree to which people engage in self-enhancement by believing that they are better than others when in fact they are not. Prior studies have often confounded desirability with commonness and have used subjective measures of comparative judgment that capitalize on people’s tendency to conflate relative with absolute self-evaluation.     

Financial prospect relativity: context effects in financial decision‐making under risk

We report three studies in which methodologies from psychophysics are adapted to investigate context effects on individual financial decision‐making under risk. The aim was to determine how the range and the rank of the options offered as saving amounts and levels of investment risk influence people's decisions about these variables. In the range manipulation, participants were presented with either a full range of choice options or a limited subset, while in the rank manipulation they were presented with a skewed set of feasible options. The results showed that choices are affected by the position of each option in the range and the rank of presented options, which suggests that judgments and choices are relative. Copyright © 2006 John Wiley & Sons, Ltd.     

Calibration accuracy of a judgmental process that predicts the commercial success of new product ideas

We examine the accuracy of forecasts of the commercial potential of new product ideas by experts at an Inventor's Assistance Program (IAP). Each idea is evaluated in terms of 37 attributes or cues, which are subjectively rated and intuitively combined by an IAP expert to arrive at a forecast of the idea's commercialization prospects. Data regarding actual commercialization outcomes for 559 new product ideas were collected to examine the accuracy of the IAP forecasts. The intensive evaluation of each idea conducted by the IAP produces forecasts that accurately rank order the ideas in terms of their probability of commercialization. The focus of the evaluation process on case‐specific evidence that distinguishes one idea from another, however, and the corresponding neglect of aggregate considerations such as the base rate (BR) and predictability of commercialization for new product ideas in general, yields forecasts that are systematically miscalibrated in terms of their correspondence to the actual probability of commercialization. Copyright © 2007 John Wiley & Sons, Ltd.     

Second-order beliefs about intention and children's attributions of sociomoral judgment

Predicting how another person will evaluate the intention underlying an action involves consideration of second-order mental states. Children (ages 5-10 years) and college students (N=105) predicted an observer's belief about an actor's intention and evaluated the actor from both their own perspectives and the perspective of the observer. Younger children were more likely than older children and adults to attribute a belief to the observer that mismatched the actor's prior intention. Attributed beliefs about intention were more likely to match negative prior intentions than to match positive prior intentions and were also more likely to match prior intentions when the observer knew the actor's prior intention than when the observer did not know the actor's prior intention. The judgments attributed to the observer were based on the beliefs about intention attributed to the observer, showing use of second-order mental states to infer another's sociomoral judgments.     

The development of possibility judgment within and across domains

The ability to differentiate possible events from impossible ones is an invaluable skill when reasoning about claims that transcend the perceptual evidence at hand, yet preschool-aged children do not readily make this differentiation when reasoning about physically extraordinary events [Shtulman, A., &; Carey, S. (2007). Improbable or impossible? How children reason about the possibility of extraordinary claims. Child Development, 78, 1015–1032]. The present study sought to determine whether this failure stems from deficits in domain-specific knowledge or deficits in the domain-general procedure by which possibility judgments are made. Participants (48 children aged 4-9 years olds and 16 adults) were asked to judge the possibility of three types of extraordinary events – physical, psychological, and biological – and to justify their judgments of impossibility. Developmental changes in the ability to differentiate improbable events from impossible events were qualitatively similar across domains. Moreover, participants’ propensity to judge improbable events possible was significantly correlated with the quality of their justifications, both within and across domains. These findings suggest that modal development involves a domain-general change in how modal claims are evaluated.     

药物性肝损伤的诊断思维

药物性肝损伤（DILI）是指由于药物或其代谢产物引起的肝脏损害。DILI的诊断尚无金标准,目前国际上比较常用的诊断标准分别从数个不同方面各自进行量化评分,根据得分情况做出诊断。本文归纳DILI的产生机制、诊断标准、临床分型及病理类型,总结推论其临床诊断思维与决策,以供临床医生参考,提高诊断水平。     

Mysteries of morality

Evolutionary theories of morality, beginning with Darwin, have focused on explanations for altruism. More generally, these accounts have concentrated on conscience (self-regulatory mechanisms) to the neglect of condemnation (mechanisms for punishing others). As a result, few theoretical tools are available for understanding the rapidly accumulating data surrounding third-party judgment and punishment. Here we consider the strategic interactions among actors, victims, and third-parties to help illuminate condemnation. We argue that basic differences between the adaptive problems faced by actors and third-parties indicate that actor conscience and third-party condemnation are likely performed by different cognitive mechanisms. Further, we argue that current theories of conscience do not easily explain its experimentally demonstrated insensitivity to consequences. However, these results might be explicable if conscience functions, in part, as a defense system for avoiding third-party punishment. If conscience serves defensive functions, then its computational structure should be closely tailored to the details of condemnation mechanisms. This possibility underscores the need for a better understanding of condemnation, which is important not only in itself but also for explaining the nature of conscience. We outline three evolutionary mysteries of condemnation that require further attention: third-party judgment, moralistic punishment, and moral impartiality.     

How strong is the comparison‐to‐the‐strongest heuristic?: An empirical test of the comparison‐ to‐the‐strongest heuristic in probability judgment1,2

Abstract: Windschitl and Wells (1998 ) proposed that the pairwise comparison between the focal and strongest alternative outcomes plays an important role in probability judgment. However, their studies did not control the effects of alternative outcomes other than the strongest one. This article tested whether only the strongest alternative outcome would affect probability judgment, using a variable selection method in a multiple regression analysis. Study 1 reanalyzed the results of Windschitl and Young (2001 ) and showed that only the strongest alternative outcome affects probability judgment. In Study 2, a new experiment was conducted to modify the methodological problems in Study 1. The results of Study 2 were identical to those of Study 1. All these results consistently supported the comparison hypothesis.