Principles for Designing Randomized Preventive Trials in Mental Health: An Emerging Developmental Epidemiology Paradigm

An emerging population-based paradigm is now being used to guide the design of preventive trials used to test developmental models. We discuss elements of the designs of several ongoing randomized preventive trials involving reduction of risk for children of divorce, for children who exhibit behavioral or learning problems, and for children whose parents are being treated for depression. To test developmental models using this paradigm, we introduce three classes of design issues: design for prerandomization, design for intervention, and design for postintervention. For each of these areas, we present quantitative results from power calculations. Both scientific and cost implications of these power calculations are discussed in terms of variation among subjects on preintervention measures, unit of intervention, assignment, balancing, number of pretest and posttest measures, and the examination of moderation effects.     

TREATING CHRONIC FOOD REFUSAL IN YOUNG CHILDREN: HOME-BASED PARENT TRAINING

We evaluated the effects of a behavioral parent training program on parent and child feeding-related behaviors in the home. We trained mothers to initiate regular offerings of previously rejected (target) foods and to provide contingent attention (i.e., specific prompts, positive reinforcement) to increase their child's acceptance of nonpreferred foods. For 1 subject, we also directed training at increasing self-eating. Results of a nonconcurrent multiple baseline design across 3 mother-child dyads demonstrated that, with training, all mothers increased offerings of target foods and use of specific prompts, and 2 mothers increased levels of positive attention. In turn, children increased their acceptance of target foods and self-eating, thus demonstrating the functional effects of parent training on in-home mealtimes. Temporary increases in food refusals occurred when treatment was initiated but declined as treatment continued. We discuss the results in terms of the potential benefits and limitations of a home-based treatment model.     

SELECTIVE ASSOCIATIONS PRODUCED SOLELY WITH APPETITIVE CONTINGENCIES: THE STIMULUS-REINFORCER INTERACTION REVISITED

In studies reporting stimulus-reinforcer interactions in traditional conditioning paradigms, when a tone-light compound was associated with food the light gained stimulus control, but when the compound was paired with shock avoidance the tone gained control. However, the physical nature of the reinforcerrelated events (food vs. shock) presented in the presence of the tone-light compound was always confounded with the conditioned hedonic value of the compound's presence relative to its absence. When the compound was paired with shock, its presence was negative relative to its absence (which was shock-free). In contrast, when the compound was paired with food, its presence was positive relative to its absence (which was food-free). The present experiment dealt with this confounding effect by conditioning a tone-light compound to be positive or negative, relative to its absence, solely with food reinforcement. One group of rats received food for responding in the presence of the tone-light compound and no food in its absence. The other group also responded in the presence of the compound, but received food only in its absence. These rats were trained on a chained schedule in which responding in the presence of the tone-light compound produced a terminal link signaled by the absence of the compound; responding ceased in the terminal link because it delayed food delivery. In a test session to assess stimulus control by the elements of the compound, tone and light were presented separately under extinction conditions. Rats that had been exposed to a positive correlation between food and the compound emitted almost double the responses in the presence of the light as in the presence of the tone. In comparison, rats that had been exposed to a negative correlation emitted only two thirds as many responses in the presence of the light as in the presence of the tone. Because this selective association was produced using only food, it appears that the contingencies under which a reinforcer is presented, rather than (or as well as) its physical properties, can generate the selective associations previously attributed to “stimulus-reinforcer interactions.” This could mean that regardless of the class of reinforcer that ultimately maintains responding (appetitive or aversive), the contingency-generated hedonic value of the compound stimulus may influence the dominant modality of stimulus control.     

Responding to distressed infants: Does mothers’ positive versus negative affect matter for infants' behavior and physiology?

How mothers respond to infants’ distress has implications for infants’ development of self-regulation and social competence. In a sample of 35 mothers and their 4- to 8-month-old infants, we induced infant distress using an arm restraint task and compared infants’ observed affect and physiological responses under two conditions, when mothers were instructed to respond with: 1) positive affect and 2) negative affect. Based on theoretical and empirical support, we empirically evaluated two opposing hypotheses. Based on the Mutual Regulation Model and work on affect matching, we predicted that when mothers respond with negative affect versus positive affect, distressed infants’ duration of negative affect would be smaller, negative affect would be less intense, and respiratory sinus arrythmia (RSA) withdrawal would be lower. Based on social referencing theory and research, we expected that when mothers respond with positive affect versus negative affect, distressed infants’ duration of negative affect would be smaller, negative affect would be less intense, and RSA withdrawal would be lower. We found that when mothers responded to their distressed infants with negative affect versus positive affect, infants spent significantly more time in negative affect, their intensity of expressed negative affect was greater, and their RSA withdrawal was greater, suggesting that mothers’ display of mild positive affect when infants are distressed may be helpful for infants. The current findings add to accumulating evidence that mothers’ positive relative to negative affective response to their infants’ distress can produce observable differences in infants’ duration and intensity of negative affect, as well as their physiology. Findings have the potential to inform future research that investigates how mothers can most effectively reduce their infants’ distress and intervention that targets the moment-to-moment behaviors in mother-infant reciprocal interactions.     

Infants’ behaviours elicit different verbal,nonverbal, and multimodal responses from caregivers during early play

Caregivers use a range of verbal and nonverbal behaviours when responding to their infants. Previous studies have typically focused on the role of the caregiver in providing verbal responses, while communication is inherently multimodal (involving audio and visual information) and bidirectional (exchange of information between infant and caregiver). In this paper, we present a comprehensive study of caregivers’ verbal, nonverbal, and multimodal responses to 10-month-old infants’ vocalisations and gestures during free play. A new coding scheme was used to annotate 2036 infant vocalisations and gestures of which 87.1 % received a caregiver response. Most caregiver responses were verbal, but 39.7 % of all responses were multimodal. We also examined whether different infant behaviours elicited different responses from caregivers. Infant bimodal (i.e., vocal-gestural combination) behaviours elicited high rates of verbal responses and high rates of multimodal responses, while infant gestures elicited high rates of nonverbal responses. We also found that the types of verbal and nonverbal responses differed as a function of infant behaviour. The results indicate that infants influence the rates and types of responses they receive from caregivers. When examining caregiver-child interactions, analysing caregivers’ verbal responses alone undermines the multimodal richness and bidirectionality of early communication.     

Effects of quantity and quality of home proximal processes on Dutch,Surinamese–Dutch and Turkish–Dutch pre‐schoolers’ cognitive development

This study examines the effects of mother–child literacy and problem solving interactions on 3–4‐year‐old children's cognitive development in a sample of Dutch middle‐class, Dutch lower‐class, Surinamese and Turkish immigrant families (n=130). Following the bioecological model of Bronfenbrenner and Ceci, mother–child book reading and problem solving interactions are viewed as proximal processes actualizing genetic cognitive potential. Interactions are studied from a quantitative perspective, based on questionnaire data, concerning frequency of exposure to these interactions, and a qualitative perspective, based on observational data, concerning affective quality and cognitive content. The study was designed as a 1 year longitudinal study. It was found that effects of mother–child interactions on cognitive development differed across the groups, controlling for earlier cognitive competence and family's SES. The findings are interpreted within the frame of the bioecological model and the behavioral genetic research paradigm. Copyright © 1999 John Wiley & Sons, Ltd.     

Achievement Goals in Social Interactions: Learning with Mastery vs. Performance Goals

Little work has studied achievement goals in social interaction situations. The present experiment aimed at contributing to this matter by showing the potential of social interaction (in particular disagreement) to moderate the effects of achievement goals on learning. Participants were led to think they interacted with a partner, sharing opinions about a text that they were studying. Mastery and performance goals were manipulated. During the “interaction,” they received either disagreement or agreement from this bogus partner. Results showed that a condition in which mastery goals were induced led to better learning than a performance goal condition only when the partner disagreed. No differences between goal conditions were observed when the partner agreed. Implications for achievement goal research are discussed. Part of this work was conducted during Céline Darnon’s doctoral dissertation under the supervision of Fabrizio Butera, and was written during Céline Darnon’s post-doctorate at the University of Wisconsin-Madison, USA, thanks to a Fulbright fellowship.     

事件性前瞻记忆的加工机制：来自ERP的证据

采用事件相关电位技术,对前瞻记忆的加工机制——主要是执行前的加工机制进行研究。控制条件为单纯的背景任务,实验条件为背景任务含前瞻记忆任务,对两种条件下非靶线索的行为数据进行比较,结果表明实验条件下被试的反应时显著长于控制条件,可能说明两种条件的认知过程存在差异,这种差异在ERPs上主要体现为刺激呈现200ms以后,两种条件的波形和脑地形图存在显著差异。结果支持预备注意加工和记忆加工理论,也部分支持多重加工理论     

Multi-criteria evaluation of climate policy interactions

The effectiveness of a national climate policy instrument is affected by the presence of policy interactions with other instruments that were not forecasted before its implementation. The problem can be confronted during the design of the instrument by determining forms, types and size of emerging interactions. This paper presents a systematic approach for evaluating the aggregate effect of interactions using a combination of three multi-criteria methods, the analytical hierarchy process, the multi-attribute utility theory and the Simple Multi-Attribute Ranking Technique. The first is used for determining the weight coefficients for interaction forms and sub-criteria. The other two are used for grading policy interactions under a set of three criteria and their sub-criteria. The method is tested for two pairs of interactive instruments, IPPC and EU-ETS, EU-ETS and policies for the promotion of RES, within the Hellenic climate policy framework. Consistency and robustness tests are performed. Results are commented. Copyright © 2007 John Wiley & Sons, Ltd.