奖赏环路与阿片成瘾:喙内侧被盖核的调节作用

喙内侧被盖核(RMTg)位于腹侧被盖区(VTA)的尾部, 富含抑制性的γ-氨基丁酸(GABA)能神经元.RMTg是中脑边缘多巴胺系统的一个综合调节器.它的GABA能神经元接受外侧缰核(LHb)的输入, 然后投射到VTA多巴胺能神经元, 进而抑制多巴胺的释放.这三个脑区是奖赏环路的重要组成部分, 其中RMTg在阿片类物质激活的奖赏环路中尤为重要.阿片类物质主要通过抑制RMTg GABA能神经元使VTA多巴胺能神经元去抑制, 进而激活奖赏系统.因此, RMTg有望成为治疗药物成瘾(尤其是阿片成瘾)的一个重要靶点.此外, 胆碱类物质作用于RMTg的毒蕈碱受体能够抑制阿片类物质诱导的奖赏效应.未来研究应深入探讨RMTg调控的负性奖赏环路, 这对弱化觅药动机,促进消退和戒断具有重要意义.     

A Systems Approach to the Treatment of Chemical Addiction

Therapists are increasingly considering chemical addiction from a family systems perspective. Effects of chemical dependency upon the family are discussed and intervention approaches aimed toward assisting the family as families redefine themselves and change their structure are considered. The integration of chemical dependency treatment and the family therapy is also discussed as it is practiced in an intensive outpatient program at a psychiatric hospital.     

The observational study of adolescent gambling in UK amusement arcades

In the UK, excessive fruit machine playing is the most documented form of pathological gambling amongst adolescents. Although there have been a few retrospective questionnaire studies in adolescent fruit machine gambling, there has been very little systematic observational fieldwork into the behaviour. The studies reported explore the social world of fruit machine playing using data collected via the monitoring of 33 UK amusement arcades employing participant and non-participant observation methodologies. The basic aims were to observe the arcade clientele and their behavioural characteristics, and to examine motivations for machine playing. Results suggest that level of adolescent gambling depends upon both time of day and time of year, and regular players conform to rules of etiquette and display stereotypical behaviours when playing fruit machines. The results also suggest that adolescents play fruit machines for a wide range of reasons including fun, to win money, to socialize, to escape and for excitement, and that inland and coastal arcades are frequented by different clienteles, probably as a function of the amusement machine available.     

Reflections 10 Years Post–Hurricane Katrina: Implications for Addiction Counseling

Ten years post–Hurricane Katrina, the authors reflected on the aftermath through the eyes of addiction treatment professionals to become better prepared for future tragedies. The lessons learned, the authors' personal reflections, and implications for clinical practice and counselor education are provided.     

Substance Use Assessment Instruments: 13 Years Later

The authors surveyed Master Addiction Counselors and members of the International Association of Addictions and Offender Counselors (N = 131) about their use of substance use disorder and process addiction screening and assessment instruments. The results are compared with those of Juhnke, Vacc, Curtis, Coll, and Paredes ( 2003 ).     

神经质人格与大学生网络小说成瘾关系:叙事传输和沉浸感的中介作用

本研究以502名大学生为被试,探讨神经质人格与网络小说成瘾的关系以及叙事传输和沉浸感在其中的序列中介作用。结果发现:(1)网络小说成瘾与神经质人格、叙事传输和沉浸感之间均呈显著正相关;(2)神经质人格不仅可以直接影响网络小说成瘾,还可以通过叙事传输和沉浸感的中介作用对其产生影响,且该中介作用包含了两条路径——沉浸感的单独中介作用以及叙事传输-沉浸感的序列中介作用。这一结论有助于引导大学生健康阅读网络小说,预防成瘾。     

Attachment to the Missing Object: Infidelity and Obsessive Love

In an object relations study on infidelity and obsessive love, the author observes that in relationships marked by chronic, repetitive infidelity and obsession, the lover is enamored with that which they can not have and that the psychological development of such individuals may have been traumatized by early attachment disturbances in the primary dyad. Tenacious, unsatisfying love-attachments as seen in sexual addictions and obsessional love may result from the internalization of an absent or intermittent object relationship—a morbid attachment to the missing object of infancy. Such patients often demonstrate depressive/addictive traits and schizoid defenses and typically have difficulty forming an attachment bond with the analyst, perceiving the analyst as a dangerous, rejecting agent who will recapitulate the original trauma. In the clinical case of Gretchen, the author uses Winnicott's (1960) concept of holding to create a progressive therapeutic bond, as toxic resistant forces are gradually resolved.     

Behavioral perspectives on the neuroscience of drug addiction

Neuroscientific approaches to drug addiction traditionally have been based on the premise that addiction is a process that results from brain changes that in turn result from chronic administration of drugs of abuse. An alternative approach views drug addiction as a behavioral disorder in which drugs function as preeminent reinforcers. Although there is a fundamental discrepancy between these two approaches, the emerging neuroscience of reinforcement and choice behavior eventually may shed light on the brain mechanisms involved in excessive drug use. Behavioral scientists could assist in this understanding by devoting more attention to the assessment of differences in the reinforcing strength of drugs and by attempting to develop and validate behavioral models of addiction.     

Sex Differences in Social Support and Self-Efficacy Within a Recovery Community

This study examined similarities and differences in social support and self-efficacy for abstinence between women and men recovering from substance addiction. The sample consisted of 87 residents of Oxford House (OH) self-run, community-based recovery homes. Analyses revealed similarities between women and men in terms of the composition and utilization of support networks and abstinence self-efficacy. Also, for both sexes, length of residency in OH was significantly related to decreased social support for alcohol and drug use and increased self-efficacy for abstinence. However, multiple-group SEM analyses demonstrated that social support for alcohol/drug use fully mediated the link between length of residency and abstinence self-efficacy for women, but not for men. Findings suggest that the process of gaining self-efficacy to remain abstinent is distinct for women and men, and that social support plays a different role in women's recovery than it does in men's.     

青少年外向/宜人性人格、互联网服务偏好与"网络成瘾"的关系

该研究采用问卷法,以481名中学生为被试,通过无约束结构方程模型分析方法探讨了外向性、宜人性人格特征与互联网服务偏好的交互作用对网络成瘾的影响。研究发现在对网络成瘾的影响上,青少年宜人性人格特征与互联网社交服务偏好存在显著的交互作用,但与互联网娱乐、信息和交易服务偏好的交互作用不显著。外向性人格特征与互联服务偏好不存在显著的交互作用。(1)从平均影响来看,外向性、宜人性、互联网社交、娱乐和交易使用偏好能够正向预测网络成瘾,互联网信息使用偏好对网络成瘾没有显著的预测效果;(2)在宜人性高分组中,互联网社交服务偏好与PIU的正向关系要强于宜人性低分组。斜率检验表明对于低宜人性人格的青少年来说,互联网社交服务偏好不易导致其成瘾,而对高宜人性人格的青少年而言,互联网社交服务偏好反而容易导致其成瘾。