伦理委员会持续审查制度建设探讨

持续审查作为伦理审查的重要环节, 是保护受试者的重要机制。但在我国的伦理审查实践中, 持续审查却一直没有得到应有的重视和规范。究其原因, 不仅是因为相关法律法规的缺失, 还因为在执行层面也缺少相对明确和具体的制度和标准操作规程。在借鉴美国持续审查制度建设相关经验的基础上, 结合北京大学生物医学伦理委员会制度建设实践, 对持续审查的范围、频率、形式、内容和标准等问题展开论述和探讨。     

父母差别对待与青少年问题行为的关系：一个有调节的中介模型

通过问卷调查的方式,采用同胞不同经历问卷、关系网络问卷和问题行为量表对开封市1179名初高中学生进行研究。研究结果显示：（1）父母差别对待与外/内化问题行为呈显著正相关;同胞关系与外/内化问题行为呈显著负相关;父母差别对待和同胞关系呈显著负相关。（2）同胞关系在父母差别对待与外/内化问题行为之间起部分中介作用。（3）“父母差别对待→同胞关系→外/内化问题行为”这一中介路径的前半段受出生顺序调节;与年幼个体相比,父母差别对待对年长个体的同胞关系影响更大。出生顺序会调节父母差别对待对同胞关系的影响,提示二胎家庭要更关注年长个体的变化。     

适宜技术与诊疗最优化的可行性研究

在案例分析的基础上,作出了医生是临床诊疗中适宜技术的主要选择者的判断;论证了运用适宜技术实现诊疗最优化的可行性;认为适宜技术难以选择和实施的主要原因是利益关系、责任心不强和管理措施不到位;提出了必须着力培育适合于适宜技术生长的土壤的对策,即:实行政策引导与资金支持、进一步加大监管力度、营造良好的氛围、高度重视并加强医生道德素质的培养。     

INCREASING CALORIE CONSUMPTION IN CHILDREN WITH CYSTIC FIBROSIS: REPLICATION WITH 2-YEAR FOLLOW-UP

Three mildly malnourished children with cystic fibrosis and their parents participated in a behavioral group-treatment program that focused on promoting and maintaining increased calorie consumption. Treatment included nutritional education, gradually increasing calorie goals, contingency management, and relaxation training, and was evaluated in a multiple baseline design across four meals. Children's calorie intake increased across meals, and total calorie intake was 32% to 60% above baseline at posttreatment. Increased calorie consumption was maintained at the 96-week follow-up (2 years posttreatment). The children's growth rates in weight and height were greater during the 2 years following treatment than the year prior to treatment. Increases in pace of eating and calories consumed per minute were also observed 1 year posttreatment. These findings replicated and extended earlier research supporting the efficacy of behavioral intervention in the treatment of malnutrition in children with cystic fibrosis.     

Assessing Preferences Among Behavioral Interventions With Japanese Parents of Children With Developmental Disabilities

As the cultural dynamic continues to become increasingly complex, it is critical to assess cultural factors that influence practice. The present study considers the treatment preferences of Japanese mothers of children with developmental disabilities. After answering demographic questions, each participant was given four scenarios and asked how they would respond by choosing one of four interventions (differential reinforcement, ignoring, reprimanding, and time-out). Overall, we found that parents preferred differential reinforcement strategies the most. Moreover, parents who reported that their children had a history of involvement with applied behavior analysis were especially likely to choose differential reinforcement. Implications for future research and practice are provided.     

二胎家庭的父母养育

随着我国全面二胎政策的实施,关于二胎家庭父母养育的问题越来越受到社会的广泛关注。但是,在我国这方面的研究极度稀缺。本文就二胎家庭父母养育的表现形式、影响因素及作用机制进行论述。二胎家庭父母养育的表现形式包括父母差别对待、协调同胞关系等。二胎家庭父母养育的影响因素包括父母养育第一胎的经验、婚姻质量、协同养育、儿童特点等。二胎父母养育的作用机制包括父母差别对待造成的儿童心理发展问题,以及父母在协调同胞关系中的作用。此外,本文结合已有文献,提出了一个"二胎家庭父母养育的过程机制"模型,揭示在二胎家庭情境下,各种因素是如何影响父母的养育模式,又通过哪些作用机制对家中的两个孩子产生影响。最后,强调未来我国的研究者应该重视本土化,关注社会变迁中二胎父母养育的特点。     

Family-Based Therapy for Adolescent Drug Abuse: Knowns and Unknowns

Family-based therapy is one of the most thoroughly studied treatments for adolescent drug abuse. Considerable empirical support exists for the efficacy of family-based therapy in curtailing adolescent drug use and cooccurring behavior problems. This article extends knowledge of the effects of family-based therapy for adolescent drug abuse by reviewing 16 controlled trials and 4 therapy process studies from a treatment development perspective. We articulate knowns and unknowns regarding the outcomes of treatment as well as the components, processes, mechanisms, moderators, and boundaries of effective family-based therapy for adolescent drug abuse. The review highlights areas of progress and future research needs within the specialty of family-based therapy for adolescent drug abuse.     

Social Desirability in Patients Seeking Surgical Treatment for Dentofacial Disharmony: Associations with Psychological Distress and Motivation for Treatment

The role of socially desirable responding in the report of treatment motivation and psychological distress by patients seeking surgical treatment for dentofacial disharmony was explored. Participants completed the Balanced Inventory of Desirable Responding (BIDR; Paulhus, 1988), which measures two components of socially desirable responding (SDR): impression management (IM), which is the purposeful tailoring of answers in order to create the most positive social image, and self-deceptive positivity (SDE), which is an honest, but overly positive self-presentation. When simple bivariate relationships were examined, statistically significant inverse associations were observed between socially desirable responding and specific motives for treatment and between SDR and psychological distress. However, the relationship between socially desirable responding and motives for treatment disappeared when the effect of psychological distress was controlled. The positive relationship between psychological distress and the report of social well-being, and self-image motives for treatment remained statistically significant even after the variance attributable to socially desirable responding was removed. Implications of the findings for the evaluation of psychological distress and treatment motivation in this population are discussed.     

Influence of Time in Treatment and Follow-Up Duration on Methadone Treatment Outcomes

Data for 422 methadone treatment clients in the National Treatment Improvement Evaluation Study (NTIES) were analyzed. Clients maintained continuously in methadone treatment for longer than 12 months and clients who leftbetween 3–12 months were compared with clients treated for less than 3 months. Additionally, clients treated for 3–12 months who had short follow-up periods (6-month average) were compared with 3–12-month clients with long follow-up periods (11-month average). Positive treatment outcomes includinglower drug use, reduced risk of viral infectionand sexually transmitted disease (through needle sharing and multiple sex partners), and less criminality wereassociated with both longer duration treatment and shorter follow-up periods. The findings suggested that continuous methadone treatment of 12 or more months is optimal, whereas stays of less than3 months may be ineffective. Furthermore, stays of 3–12 months are likelyto be beneficial over a relatively short time span, for example 6 months.