难治性丙型肝炎研究新进展

随着聚乙二醇化干扰素(IFN)的普及应用和慢性丙型肝炎规范化治疗的开展,其治愈率不断提高.但疗效不佳的慢性丙型肝炎患者不断积累,难治性慢性丙型肝炎患者成为临床医生必须面对的挑战.难治性丙型肝炎患者应当分为两类,第一类为“难治疗”性慢性丙型肝炎患者,该类患者由于宿主条件限制,不能耐受IFN联合利巴韦林(RBV)的标准治疗,如儿童和老年人、慢性肾功能衰竭患者等.第二类为“难治愈”性慢性丙型肝炎患者,该类患者可以耐受标准治疗方案,但按照应答指导的治疗原则(RGT)治疗后,效果仍然不佳或复发.本文就近年关于难治性丙型肝炎的研究进展,从难治性丙型肝炎的定义、机制、治疗诸方面作一综述.     

Can Muslims Befriend Non-Muslims? Debating al-walāʾ wa-al-barāʾ (Loyalty and Disavowal) in Theory and Practice

This article analyzes the polemic on the concept of al-walā? wa-al-barā? (commonly translated as “loyalty and disavowal”). While existing academic literature focuses on the usages of this concept by jihad activists, the article centers on the role “loyalty and disavowal” plays in debates between contemporary salafī and wasa?ī jurists and theologians, specifically in their conflicting agendas for Muslims living as minorities. Salafīs, relying on several qur'anic verses and Prophetic traditions, promote an understanding of “loyalty and disavowal” that requires Muslims to refrain from befriending or loving non-Muslims, or imitating their beliefs and customs. Relying on counter-verses and traditions, in particular Q 60.8, wasa?īs have interpreted the concept of “loyalty and disavowal” more narrowly, arguing that it applies only to non-Muslims who fight against Muslims; as part of their integration-oriented doctrine for Muslims in the West, they have in recent years dedicated considerable efforts to refuting the salafī interpretation of al-walā? wa-al-barā?. The article examines the juristic methodologies utilized in the debate, and how it has affected religious decisions (fatwās) on Islamic life in Western societies.     

Problematic,absent and stigmatizing diagnoses in current mental disorders classifications: Results from the WHO-WPA and WHO-IUPsyS Global Surveys

This study examined English- and Spanish-speaking psychologists’ and psychiatrists’ opinions regarding problematic, absent and stigmatizing diagnoses in current mental disorders classifications (ICD-10 and DSM-IV), and their perceived need for a national classification of mental disorders. Answers to open-ended questions included in WHO-WPA and WHO-IUPsyS surveys were examined using an inductive content-analysis method. A total of 3,222 participants from 35 countries were included. The most problematic diagnostic group was personality disorders, especially among psychiatrists, because of poor validity and lack of specificity. Complex posttraumatic stress disorder was the most frequent diagnosis suggested for inclusion, mainly by psychologists, to better account for the distinct processes and consequences of complex trauma. Schizophrenia was the diagnosis most frequently identified as stigmatizing, particularly by psychiatrists, due to lack of public understanding or knowledge about the diagnosis. Of the 14.4% of participants who perceived a need for a national classification system, two-thirds were from Africa or Latin America. The rationales provided were that mental disorders classifications should consider cultural and socio-historical diversity in the expression of psychopathology, differences in the perception of what is and is not pathological in different nations, and the existence of culture-bound syndromes. Implications for ICD-11 development and dissemination are discussed.     

Implicit Association Test (IAT) Studies Investigating Pitch-Shape Audiovisual Cross-modal Associations Across Language Groups

Previous studies have shown that Chinese speakers and non-Chinese speakers exhibit different patterns of cross-modal congruence for the lexical tones of Mandarin Chinese, depending on which features of the pitch they attend to. But is this pattern of language-specific listening a conscious cultural strategy or an automatic processing effect? If automatic, does it also apply when the same pitch contours no longer sound like speech? Implicit Association Tests (IATs) provide an indirect measure of cross-modal association. In a series of IAT studies, conducted with participants with three kinds of language backgrounds (Chinese-dominant bilinguals, Chinese balanced bilinguals, and English speakers with no Chinese experience) we find language-specific congruence effects for Mandarin lexical tones but not for matched sine-wave stimuli. That is, for linguistic stimuli, non-Chinese speakers show advantages for pitch-height congruence (high-pointy, low-curvy); no congruence effects were found for Chinese speakers. For non-linguistic stimuli, all participant groups showed advantages for pitch-height congruence. The present findings suggest that non-lexical tone congruence (high-pointy, low-curvy) is a basic congruence pattern, and the acquisition of a language with lexical tone can alter this perception.     

Propiedades psicométricas de un test adaptativo informatizado de vocabulario inglés

Resumen

Se aplicó el modelo logístico de tres parámetros de la TRI a un banco de items de vocabulario inglés. Se compararon los niveles de habilidad estimados a partir del banco completo con los estimados a partir de una TAI basado en el principio de máxima información y con el rendimiento en el Oxford Placement Test (Allan, 1992). La principales conclusiones fueron: a) El banco de items resulta especialmente informativo para niveles medios de habilidad, b) Las distribuciones de los tres parámetros resultan adecuadas, c) Como resultaba previsible, existe una relación lineal elevada (r = 0.9) entre las estimaciones realizadas a partir de las respuestas al banco completo y al TAI, d) Ambas estimaciones se predicen significativamente a partir de las dos puntuaciones que proporciona el Oxford Placement Test.     

ART伦理督导的实践与评价

在生殖中心(医院)中,将伦理原则的学习与技术规范的掌握相结合,将伦理学评价与员工的奖惩机制相结合,将伦理学研究与管理骨干的培养相结合,将伦理原则的贯彻与工作总结相结合;发挥医学伦理委员会监督的权威作用,重视群众监督手段的督促作用,借助国家行政督导机构和行业法规的震慑作用,是ART增强道德约束能力的有效机制。     

Do you get what you pay for? Preventing insufficient effort responding in MTurk and student samples

Previous research has developed multiple indices to detect instances of insufficient effort responding (IER; Huang et al., 2015, 0.1037/a0038510). Although these techniques are largely successful, conflation between effort and insufficient effort leads to unnecessary data removal, thus warranting investigation into IER prevention strategies such as warning statements. For example, Brühlmann et al. (2020, 10.1016/j.metip.2020.100022) reported that close to 60% of participants were flagged for IER on at least one IER detection index. The current study used positive, negative, and no warning statements in two samples (MTurk and university participant pool) to examine their impact on two types of IER. Results do not support the use of warning statements to reduce IER covertly, overtly, or overall. Although slightly more university participants were flagged for IER for two of five IER indices, the remaining three indices did not differ between samples. This finding represents an important contribution to survey research literature by directly comparing samples on a variety of IER indices. Implications for survey research necessitate the examination of additional prevention strategies and sample differences in IER.     

心理账户:缘起、理论及应用

心理账户深刻地体现了心理学和经济学的结合,是在行为经济学的大背景下开始研究的。心理账户是人们在心理上对结果,尤其是经济结果的编码,分类和估价的过程,它反映了人们在进行资金财富决策过程中的心理认知过程。心理账户与经济账户的运算法则不同,它具有非替代性。心理账户与金融投资结合形成了行为资产组合理论,心理账户与消费经济结合,形成了行为生命周期理论。