铁过度负荷与疾病

铁是机体微量元素中含量最多的一种,是血红蛋白、肌红蛋白、细胞色素系统、呼吸链的主要复合物、过氧物酶和过氧化氢酶等的重要组成部分,广泛参与机体生理功能和生化反应,缺铁可导致贫血等疾病。体内铁过多,称为铁过度负荷。随着医疗条件改善、生活水平提高,源于生理性因素、病理性因素和外源性铁剂应用(治疗性应用、预防性应用),铁过度负荷相关疾病日益增多。铁过度负荷可对内分泌代谢、心血管、神经系统、肾脏、肝脏等系统器官产生损害,导致多种疾病或使疾病加重。目前铁过度负荷相关疾病的治疗措施主要有放血疗法和药物治疗。放血疗法,只可作于短期治疗。去铁胺作为目前较为有效的去铁剂,由于价格昂贵,不能广泛应用于临床。铁过度负荷对人体的影响和相关疾病尚未外起医学界的重视。深入研究以铁过度负荷为主要和次要病因相关疾病,探索正确补铁措施,是预防铁过度负荷相关疾病、增进人体健康的重要措施,也是临床面临床的新课题。     

试论张仲景辩病结合辩证的辨证论治方法的先进性

张仲景辩病结合辩证的辨证论治方法,与现代医学认识疾病的思想非常近似,通过比较现代医学认识疾病思想与张仲景疾病认识概念在疾病诊治过程中的相似性,为研究<金匮要略>古代疾病与西医现代病的对应性结合、提高病证结合论治在临床的效验,有很大意义.     

从幽门螺旋杆菌的发现看中西医结合模式

从幽门螺旋杆菌的发现及中西医对其与胃炎、上消化道溃疡乃至胃癌的关系研究,探讨中西医不同的看法及结论,提出并证明对中西医结合必须要：１．超然于东西方传统文化观念之上,超脱于整体观与还原论之外;２．建主结构精确,逻辑严密的系统与模式;３．在基本理论和概念上有所取舍,有所发扬,有所更新。     

辩证思维在心脏外科疾病诊治中的应用

辩证思维是最普遍适用,最重要的科学思维方法之一.介绍尝试将辩证思维应用于心脏外科工作中的心得,并用具体案例介绍了在心脏外科疾病的诊断与治疗中辩证思维常用的基本原则.     

一个新的中医研究范式:从非线性动力学的角度解读中医

西方对中医的研究多是利用随机控制试验来检验其疗效。通过讨论,认为这类研究有其局限性。同时探讨一种新的研究范式,即非线性动力学理论。认为这一理论能够提供理论依据来设计适合中医特征的临床试验,并可望得出为西方医学界所接受的研究结果。     

从SARS到EV71：国外传染病疫情监测预警经验及其启示

英国、美国和法国在传染病疫情监测预警方面积累了丰富的经验,本文从不同角度简要介绍了这三个国家的传染病监测经验,并从疫情监测形式、检验检测水平、专业人员能力、疫情信息报告等方面分析了我国疫情监测预警系统存在的问题和差距,最后针对性地提出了一些政策建议。     

Improving Service Evaluation in Clinical Genetics: Identifying Effects of Genetic Diseases on Individuals and Families

Outcome measurement in clinical genetics is challenging. Outcome attributes used currently have been developed by service providers or adapted from measures used in other areas of healthcare. Many of the ‘patients’ in clinical genetics are healthy but at risk of developing or transmitting a condition. Usually no pharmacological or surgical treatment is offered, although information-giving is an objective of most consultations. We argue that services should be evaluated on the basis of how well they alleviate the effects of disease, from a patient perspective. This paper describes a qualitative study using seven focus groups with health professionals, patients and patient representatives. Social and emotional effects of genetics diseases were identified. Some differences emerged between the effects identified by health professionals and those identified by patients. These findings will be used to inform the evaluation of existing outcome measures and develop robust measures of outcome for clinical genetics services.     

Abuse Experiences in a Community Sample of Young Adults: Relations with Psychiatric Disorders, Sexual Risk Behaviors, and Sexually Transmitted Diseases

This study documents significant associations among lifetime abuse experiences, psychiatric diagnoses, and sexual risk behaviors in a multiethnic community sample of young men and women (N = 1803) in South Florida. Self-report data were collected via structured interviews as part of a longitudinal follow-up of a larger school-based study. Participants were grouped according to extent of lifetime abuse experiences. Cumulative lifetime abuse experiences were associated with increased risk for a broad range of individual lifetime psychiatric disorders, as well as cumulative lifetime psychiatric disorders. Both cumulative abuse experiences and cumulative psychiatric disorders were independently associated with (a) higher levels of sexual risk behaviors and (b) higher risk for lifetime sexually transmitted diseases (STDs). Implications for selective prevention of sexual risk behaviors and STDs among young adults with histories of abuse and psychiatric disorders are discussed.     

Coping strategies of mother carers of children living with chronic illness and disease in a rural South African community

The present study explored the coping strategies used by mother carers of children living with chronic illness and disease (CID) in a rural South African community. Ten mothers (age range = 30 to 56 years) were selected through snowball sampling to participate in the present study. They provided care to their children, a majority (50%) of whom had epilepsy, followed by asthma (20%) and other conditions. Data on the coping strategies used by mothers of children living with CID were collected using semi-structured interviews and analysed thematically. The results showed that mother carers tended to use three types of coping strategies, namely: appraisal-focused, problem-focused and emotion-focused strategies. Appraisal-focused was commonly used by mother carers whose children had epilepsy, whilst mother carers of children with asthma tended to use problem-focused coping strategies. All mother carers were found to use emotion-focused strategies to varying degrees in coping with the chronic diseases of their children.     

消化系统疾病与精神心理因素的辩证关系

消化系统疾病与精神心理因素相互影响,其相互作用呈现个体化差异,这与个体间的内环境以及外环境差别有关。主要病理生理学机制之一为"脑-肠轴"及"脑肠互动"学说。临床医生需要认识到二者之间辩证关系的普遍性和重要性,及时发现躯体症状背后潜藏的精神心理问题,综合运用各种心理干预和药物治疗手段。