Neural functional organization of hallucinations in schizophrenia: Multisensory dissolution of pathological emergence in consciousness

Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas.     

A multilevel moderated mediational model of the daily relationships between hassles,exhaustion, ego-resiliency and resulting emotional inertia

Negative emotional inertia refers to the degree of which a current emotional state can be predicted by a previous emotional state and it represents a relevant marker of psychological maladjustment. The current study tested a theoretical model in which the dynamic impact of daily hassles on negative emotional inertia is mediated by exhaustion, and moderated by individuals’ level of ego-resiliency. Participants were 173 sophomore students (60% females) who completed two diaries per day (every morning and evening) for 18 days. In line with our predictions, the results suggest that ego-resiliency is a key personal resource that might be able to buffer the detrimental effects of daily stressors on individuals’ negative emotional inertia. In addition, our study introduced exhaustion as a potential antecedent of inertia of negative emotions. Overall, our results support the value of exhaustion as the mediator, and of ego resiliency as the moderator, of the longitudinal relation between daily hassles and emotional inertia.     

The impact of different product formats on inaction inertia

ABSTRACT

The inaction inertia effect describes situations in which a person rejects an opportunity after having forgone a relatively superior opportunity. This study explores whether product format (hedonic vs. utilitarian) affects the inaction inertia effect. The authors build on previous findings that show comparisons of utilitarian benefits are easier than hedonic benefits, and hedonic consumption (vs. utilitarian consumption) usually generates greater pleasure. The authors propose that people show higher inaction inertia after they have missed a superior utilitarian consumption opportunity than after they have missed a superior hedonic consumption opportunity. This prediction was tested and supported in three different experiments. Moreover, the authors found that differences in comparability between products, rather than the hedonic pleasure, explain differences in inaction inertia effects. These findings contribute to the inaction inertia literature and marketing practice.     

Inaction inertia

Inaction inertia occurs when bypassing an initial action opportunity has the effect of decreasing the likelihood that subsequent similar action opportunities will be taken. This overview of the inaction inertia literature demonstrates the impact of inaction inertia on decision making. Based on research on the causes of inaction inertia, we show that it is a multi-determined phenomenon, explained by both valuation and regret considerations. Moreover, we demonstrate how a sour grapes explanation of inaction inertia might integrate these two accounts. Furthermore, we explain when inaction inertia is most likely to occur and how it can be prevented. We conclude that the inaction inertia literature does not only add to our understanding of this intriguing phenomenon, but also contributes to related social psychological phenomena, such as the sunk cost effect, sequential decision making, decision avoidance (e.g., choice deferral, status quo bias, decisional conflict), and procrastination.     

任务切换理论争议新证据

任务切换是研究认知控制的主要范式之一。大量研究发现切换试次比重复试次的反应时更长,错误率更高,这种差异称为切换代价。任务切换时所产生切换代价的理论解释主要有惯性论、重构论和联结论。近十年来,这些理论均获得新的实验支持和发展,但其争议依旧,没有哪一理论能成功解释任务切换的所有效应。未来研究可以建立整合模型,以准确描述切换代价产生的认知机制。     

White matter development during adolescence as shown by diffusion MRI

Previous volumetric developmental MRI studies of the brain have shown white matter development continuing through adolescence and into adulthood. This review presents current findings regarding white matter development and organization from diffusion MRI studies. The general trend during adolescence (age 12–18 years) is towards increasing fractional anisotropy (FA) with age and decreasing mean diffusivity (MD) with age, findings primarily due to decreasing radial diffusivity with age. However, results of studies vary as to the regional specificity of such age-related changes, likely due in part to methodological issues. Another general trend is for FA to positively correlate and MD to negatively correlate with cognitive function. This trend is however region-specific, task-specific, and population-specific; some studies have in fact found negative correlations of FA and positive correlations of MD in specific regions with specific measures of cognitive performance. There are also published reports of sexual dimorphism in white matter development, indicating differing developmental trajectories between males and females as well as differing relationships developmentally between white matter architecture and cognitive function. There is a need for more research to further elucidate the development of white matter and its relation to cognitive function during this critical developmental period.     

The effects of social comparison on inaction inertia

In this paper, we examine inaction inertia in a social context where the decision-maker is among others who are faced with similar current and past opportunities. We specifically investigate whether the likelihood of taking advantage of a current opportunity after having missed a previous, relatively superior opportunity depends on whether a referent other did or did not take advantage of the previous opportunity. We report results from three studies that provide evidence for the interplay between the past actions and inactions of a referent other and the extent of inaction inertia displayed by a focal decision-maker. We also show that the proximity of the other and the valence of the relationship between the decision-maker and the other influence the extent to which the decision of the other impacts the likelihood to take action. And, finally, we show that regret mediates the relationship between the decision of the other with respect to the past opportunity and the decision-maker's likelihood of taking advantage of the current opportunity.     

经典力学革命中的概念图式变化

经典力学革命中起核心作用的是运动概念的变化。亚里士多德力学把运动理解成位移,这种运动概念与因果解释图式一起,限定了力学解释的基本特征。为了解决抛体问题而引入的冲力理论是一个过渡,伽利略在用冲力理论解释自由落体运动时改变了思考问题的方向,转向新的运动概念——运动就是瞬时运动。这个概念结合力学解释的因果图式预告了惯性定律。     

Dealing with missed opportunities: Action vs. state orientation moderates inaction inertia

Inaction inertia refers to the effect that missing a more attractive opportunity decreases the likelihood to act on an attractive current opportunity in the same domain. We studied the influence of how people cope with negative decision outcomes (i.e., action vs. state orientation) on this inaction inertia effect. Experiment 1 used an experimental induction of action vs. state orientation and confirmed our prediction that state oriented people showed more inaction inertia than action oriented people. Experiment 2 replicated these results with a measure of chronic action orientation and showed a mediating effect of valuation of the current opportunity. Experiment 3 showed that temporal segregation of the current from the missed opportunity decreased inaction inertia effects for state oriented, but not for action oriented people. We discuss the implications of these results for the inaction inertia and action vs. state orientation literatures.     

扩散张量成像在弱视中应用的探讨

弱视是儿童常见眼科疾病,发病机制目前尚不完全清楚。扩散张量成像（diffusion tensor imaging,DTI）是MRI技术的一个新应用,将DTI引入弱视发病机制的研究使人们能更加直观地研究弱视患者视路相关结构有否解剖改变。正确运用哲学观点、充分发挥创新能力并灵活选用适宜技术与高新技术以期达到弱视诊断的最优化。