药物性肝损伤的临床处置策略

本文讨论了药物性肝损伤治疗的相关临床问题,概括出以下几点：（1）可预知性与不可预知性肝毒性药物的临床处置方法,强调治疗的关键是停止肝毒性药物的使用以及停药的具体指征;（2）支持治疗不应被忽视,以及如何实施;（3）解毒药物的概念和种类;（4）保肝药物应用中存在的问题,主要是不按药理机理选择和多重用药,介绍了保肝药的不同机理和代表药物,阐述不要多种保肝药联合的基本原则;（5）根据肝损伤临床类型选择不同的治疗方案,肝细胞损伤以保肝药物治疗为主,胆汁淤积以利胆治疗为主,对重症肝损伤者应人工肝支持治疗,必要时进行肝移植.     

Optimism as a predictor of the effects of laboratory‐induced stress on fears and hope

The objective of the current study is to explore optimism as a predictor of personal and collective fear, as well as hope, following laboratory‐induced stress. Students (N = 107; 74 female, 33 male) were assigned randomly to either the experimental (stress—political violence video clip) or the control group (no‐stress—nature video clip). Questionnaires of fear and hope were administered immediately after the experiment (Time 1) and 3 weeks later (Time 2). Structural equation modeling indicated the following: (a) Optimism significantly predicted both fear and hope in the stress group at Time 1, but not in the no‐stress group. (b) Optimism predicted hope but not fear at Time 2 in the stress group. (c) Hope at Time 1 significantly predicted hope at Time 2, in both the stress and the no‐stress groups. (d) Gender did not predict significantly fear at Time 1 in the stress group, despite a significant difference between genders. This study supports previous studies indicating that optimism plays an important role in people's coping with stress. However, based on our research the data raise the question of whether optimism, by itself, or environmental stress, by itself, may accurately predict stress response.     

Saintliness and the Moral Life

Drawing on the work of Raimond Gaita, the paper considers the role that may be played by the lives of the saints, both in alerting us to the moral standing of other human beings, and in helping us to articulate the concept of “humanity” understood in a morally rich sense. The paper considers whether Gaita's treatment of these themes presents something like a natural law ethic, in the sense of supplying arguments which favour broadly Christian conclusions without depending upon explicitly Christian premises. It also considers whether Gaita's view, contrary to his own belief, invites extrapolation in the direction of a more religiously engaged stance. In these ways, the paper aims to address the question of the relationship between religious and moral understanding in terms that are arguably more fruitful than those suggested by the dominant ethical theories.     

Permissible killing and the irrelevance of being human

This is a review essay of Jeff McMahan's recent book The Ethics of Killing: Problems at the Margins of Life (OUP: 2002). In the first part, I lay out the central features of McMahan's account of the wrongness of killing and its implications for when it is permissible to kill. In the second part of the essay, I argue that we ought not to accept McMahan's rejection of species membership as having any bearing on whether it is permissible to kill a particular individual, as there are ways of understanding its relevance that are more plausible than McMahan allows. A review essay of Jeff McMahan. The Ethics of Killing: Problems at the Margins of Life (Oxford: Oxford University Press, 2002).     

The contribution of category‐based and contextual suppression towards retrieval‐induced forgetting1

Abstract: This study examines whether both context‐related and category‐related memory impairment can be found using a retrieval‐induced forgetting procedure. One group of participants was tested using a standard retrieval‐practice paradigm, whereas for the no‐practice group the retrieval practice was replaced by irrelevant filler activity. The results showed that the within‐participant baseline items were recalled more poorly by the practice group than by the no‐practice group, whereas the practice group showed the standard retrieval‐induced forgetting effect. Thus, retrieval practice impaired recall for both within‐category and baseline items, although it impaired the former to a greater extent. This finding suggests that it is necessary to consider not only categorical relationships between items, but also context information shared by items when exploring retrieval‐induced forgetting.     

Parental Responsibility and the Morality of Selective Abortion

It is now a common opinion in Western countries that a child's impairment would probably place an unexpected burden on her parents, a burden that the parents have not committed themselves to dealing with. Therefore, selective abortion is in general a morally justified option for the parents. I argue that this view is based on biased information about the quality of life of individuals with impairments and their families. Also, a conscious decision to procreate should bring about conscious assent to assuming obligations as a parent. This implies a duty of caring for any kind of child. Consequently, if the child's condition is not such that it would make its life not worth living, and if the parents live in an environment where they are able to provide their child and themselves an adequate well-being, they do not have a morally sufficient reason to terminate the pregnancy on the grounds of fetal abnormality.     

Abortion and the human animal.

I discuss three topics. First, there is a philosophical connecting thread between several recent trends in the abortion discussion, namely, the issue of our animal nature, and physical embodiment. The philosophical name given to the position that you and I are essentially human animals is "animalism." In Section II of this paper, I argue that animalism provides a unifying theme to recent discussions of abortion. In Section III, I discuss what we do not find among recent trends in the abortion discussion, namely "the right to privacy." I suggest some reasons why the right to privacy is conspicuous by its absence. Finally, I address Patrick Lee's claim that the evil of abortion involves "the moral deterioration that the act brings to those who are complicit in it, and to the culture that fosters it."     

Subcellular interactions between parallel fibre and climbing fibre signals in purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an incrase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation byCa ²⁺, diacylglycerol (DAG), and arachidonic acid (AA) is developed.Ca ²⁺ elevation is due to CF stimulation and IP3 inducedCa ²⁺ release (IICR). DAG andIP ₃ result from PF stimulation, while AA results from phospholipase A2 (PLA ₂). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.     

Thinking about “why” eliminates retrieval‐induced forgetting: Levels of construal affect retrieval dynamics

The present study examined how levels of construal affect retrieval‐induced forgetting. Higher‐level construal is associated with the focus on the similarities among stimuli, suggesting that high‐level construal promotes relational processing. Based on this fact, retrieval‐induced forgetting may be reduced or eliminated under high‐level construal condition because of the effect of relational processing. Two experiments were conducted using a retrieval‐practice paradigm with different stimuli while priming the level of construal. A meta‐analysis synthesizing the results showed that retrieval‐induced forgetting occurred under the low‐level construal condition, whereas forgetting did not occur under the high‐level construal condition. These results suggest that abstract thinking can eliminate retrieval‐induced forgetting because of relational processing, demonstrating the role of the levels of construal on memory inhibition.     

The Epistemology of Communitarian Bioethics:Traditions in the Public Debates

I consider the problem liberalism poses for bioethics.Liberalism is a view that advocates that the state remain neutralto views of the good life. This view is sometimes supported by askeptical moral epistemology that tends to propel liberalismtoward libertarianism. I argue that the possibilities for sharedagreement on moral matters are more promising than is sometimesappreciated by such a view of liberalism. Using two examples ofpublic debates of moral issues, I show that commonly sharedintuitions may ground moral principles even if they may be givendifferent weight by persons of different moral and religioustraditions. Nevertheless, the fact that the intuition andprinciple is widely shared may be sufficient to chart somedirections for public policy or cooperative action even if theydo not lead to complete agreement. As a result, I argue that aliberal communitarianism that presupposes a fairly minimalistepistemology is a legitimate approach to achieving sharedagreement in a pluralistic society.