抑郁症的脑网络失调:来自图论分析的证据

以脑成像数据为支撑,基于图论的复杂脑网络分析实现了在大尺度上对于大脑的整体定量分析,克服了传统抑郁症病理改变研究仅关注少数几个脑区的缺点。本文主要总结了:(1)基于图论的脑网络分析的概念;(2)基于图论的抑郁症研究现状;(3)以往传统研究的不足,抑郁症脑网络研究的当前总结和未来展望。总体来说:抑郁症病人脑网络的小世界属性依旧存在,但在节点指标上存在明显的异常,且随疾病发展呈线性变化,整个网络趋向于随机化。区域性的异常主要存在于默认网络和前额叶?边缘系统环路。未来研究中,任务状态下的脑网络构建和"最小生长树"技术的应用可能会为抑郁症病人的脑网络异常提供更多的信息。     

Theosis and Human Enhancement

Recent theological work on the meaning of theosis or deification has largely ignored today’s cultural context in which ordinary Christians are expected to put theosis into practice. The widespread use of various technologies of human enhancement creates expectations that might distort the interpretation of theosis. Human enhancement technologies tend to feed off the desire to expand the self, while theosis is grounded in the idea that true divinization means becoming like God in God’s own kenosis of self-giving love. The theology of theosis is a call to empty the self, not to expand it. If theosis defines the Christian life, the use of human enhancement technology is largely a matter of indifference.     

Ethical Guidance for Selecting Clinical Trials to Receive Limited Space in an Immunotherapy Production Facility

Our aims are to (1) set forth a multiprinciple system for selecting among clinical trials competing for limited space in an immunotherapy production facility that supplies products under investigation by scientific investigators; (2) defend this system by appealing to justice principles; and (3) illustrate our proposal by showing how it might be implemented. Our overarching aim is to assist manufacturers of immunotherapeutic products and other potentially breakthrough experimental therapies with the ethical task of prioritizing requests from scientific investigators when production capacity is limited.     

Believing in one’s equal rights: Self-respect as a predictor of assertiveness

In the present research self-respect is defined as a person’s ability to see the self as someone who has the same basic rights and dignity as others. Self-respect fills a gap in previous theorizing on the self because unlike other self-concepts it can be linked to assertiveness and claim making. Self-respect was empirically distinguished from self-competence and self-confidence (Study 1) as well as from psychological entitlement, self-esteem and self-acceptance (Study 2). Self-respect predicted assertive responses above and beyond these other self-scales in two correlational studies (Studies 1 and 3) and one experiment (Study 2). As predicted, self-respect was not related to aggressive responses, but psychological entitlement was (Studies 2 and 3). Implications for future research are discussed.     

Negotiating the spaces: exploring issues of human rights in an Indian text

This article is an attempt to negotiate the spaces between a number of problematic positions concerning Hinduism and human rights through the close study of one particular text, the Rājadharmaparvan of the Mahābhārata. By examining safeguards and provisions for subjects articulated in the text’s discourse of kingly duty, it engages with some of the arguments forwarded in the theoretical literature on human rights. Here it interrogates, in particular, the idea that Hinduism is distinctively incompatible with these norms in a way other historical or cultural traditions are not. The article concludes by asking whether it is possible to counter Eurocentric tendencies in global debates without furthering illiberal agendas within local ones. Discussing the appropriation of ‘Raj dharma,’ and the texts that deal with it, by the Hindu Right, it briefly outlines some recent moves in human rights theory that help facilitate the reclamation of a rich and plural textual heritage.     

The feasibility of an automated eye-tracking-modified Fagan test of memory for human faces in younger Ugandan HIV-exposed children

Objective: The Fagan Test of Infant Intelligence (FTII) uses longer gaze length for unfamiliar versus familiar human faces to gauge visual-spatial encoding, attention, and working memory in infants. Our objective was to establish the feasibility of automated eye tracking with the FTII in HIV-exposed Ugandan infants.

Method: The FTII was administered to 31 perinatally HIV-exposed noninfected (HEU) Ugandan children 6–12 months of age (11 boys; M = 0.69 years, SD = 0.14; 19 girls; M = 0.79, SD = 0.15). A series of 10 different faces were presented (familiar face exposure for 25 s followed by a gaze preference trial of 15 s with both the familiar and unfamiliar faces). Tobii X2-30 infrared camera for pupil detection provided automated eye-tracking measures of gaze location and length during presentation of Ugandan faces selected to correspond to the gender, age (adult, child), face expression, and orientation of the original FTII. Eye-tracking gaze length for unfamiliar faces was correlated with performance on the Mullen Scales of Early Learning (MSEL).

Results: Infants gazed longer at the novel picture compared to familiar across 10 novelty preference trials. Better MSEL cognitive development was correlated with proportionately longer time spent looking at the novel faces (r(30) = 0.52, p = .004); especially for the Fine Motor Cognitive Sub-scale (r(30) = 0.54, p = .002).

Conclusion: Automated eye tracking in a human face recognition test proved feasible and corresponded to the MSEL composite cognitive development in HEU infants in a resource-constrained clinical setting. Eye tracking may be a viable means of enhancing the validity and accuracy of other neurodevelopmental measures in at-risk children in sub-Saharan Africa.     

Belonging without believing: religion and attitudes towards gay marriage and abortion rights in Northern Ireland

ABSTRACT

Same-sex marriage has become a divisive issue in established western democracies. As in earlier research on abortion, there is now a growing body of studies which suggests that religious factors, such as identity, belief and practice, are the most frequent predictors of opposition towards gay marriage. Yet, what we know about the combined influence of these religious factors remains unexamined. Mindful of this omission, this study examines the relationship between regular church attendance and a belief in God on attitudes towards same-sex marriage and abortion rights. Using the recent survey data from Northern Ireland, the results suggest that not only are those who belong but do not believe distinctive in terms of their demographic makeup, but they are also significantly more likely to adopt a liberal stance in relation to both these issues – gay marriage and abortion rights – than the most religiously devout, or those who both belong and believe.     

Neo-Naturalism: A Fresh Paradigm in International Law

Dhall (2010 Dhall, Amar. 2010. On the philosophy and legal theory of human rights in light quantum holism. World Futures: The Journal of General Evolution, 66: 1–25. [Taylor &; Francis Online] , [Google Scholar]) posited that quantum holism can provide an alternate justification for human rights. This article explores how such a foundation challenges aspects of international law and assertions of cultural relativism that have stymied the ongoing development of a universal human rights culture.     

An Evolutionary Approach Toward Exploring Altered States of Consciousness,Mind–Body Techniques,and Non-Local Mind

Humans are a part of the complex system including both natural and cultural-technological environment. Evolution of this system included self-amplifying feedbacks that lead to the appearance of human conscious mind. We describe the current state of the understanding of human brain evolution that stresses neurohormonal and biochemical changes rather than simple increase of anatomical substrate for the mind. It follows that human brain is strongly influenced by the state of the body and may operate at various levels of consciousness depending on its biochemical environment created by ingestion of various substances and by specific physical activities. Through the study of the widespread phenomenon of shamanism that uses mind-altering practices we argue that altered states of consciousness and non-local minds are not only real phenomena, but that they are products of natural evolution, valuable for human survival and development. Consideration of altered states of consciousness and broadening of the framework for understanding brain function beyond mechanistic interpretations is necessary to further develop human adaptations and provide a better way of fitting humans as parts of the interconnected system into the global and universal patterns.