The Ethics of Type 1 Diabetes Prediction and Prevention Research

There are approximately one million cases oftype 1 diabetes in the US, and the incidenceis increasing worldwide. Given that two-thirdsof cases present in childhood, it is criticalthat prediction and prevention research involvechildren. In this article, I examine whethercurrent research methodologies conform to theethical guidelines enumerated by the NationalCommission for the Protection of Human Subjectsof Biomedical and Behavioral Research, andadopted into the federal regulations thatprotect research subjects. I then offer twopolicy recommendations to help researchersdesign studies that conform to these ethicalrequirements.     

Emotionally arousing pictures increase blood glucose levels and enhance recall

Arousal enhances memory in human participants and this enhancing effect is likely due to the release of peripheral epinephrine. As epinephrine does not readily enter the brain, one way that peripheral epinephrine may enhance memory is by increasing circulating blood glucose levels. The present study investigated the possibility that emotionally arousing color pictures would improve memory and elevate blood glucose levels in human participants. Blood glucose levels were measured before, 15 min, and 30 min after male university students viewed 60 emotionally arousing or relatively neutral pictures. Participants viewed each picture for 6 s and then had 10 s to rate the arousal (emotional intensity) and valence (pleasantness) of each picture. A free-recall memory test was given 30 min after the last picture was viewed. Although the emotionally arousing and neutral picture sets were given comparable valence ratings, participants who viewed the emotionally arousing pictures rated the pictures as being more arousing, recalled more pictures, and had higher blood glucose levels after viewing the pictures than did participants who viewed the neutral pictures. These findings indicate that emotionally arousing pictures increase blood glucose levels and enhance memory, and that this effect is not due to differences in the degree of pleasantness of the stimuli. These findings support the possibility that increases in circulating blood glucose levels in response to emotional arousal may be part of the biological mechanism that allows emotional arousal to enhance memory.     

The ‘redefinition of death’ debate: Western concepts and western bioethics

Biomedicine is a global enterprise constructed upon the belief in the universality of scientific truths. However, despite huge scientific advances over recent decades it has not been able to formulate a specific and universal definition of death: In fact, in its attempt to redefine death, the concept of death appears to have become immersed in ever increasing vagueness and ambiguity. Even more worrisome is that bioethics, in the form of principlism, is also endeavouring to become a global enterprise by claiming neutrality. It appears that the discourse within both disciplines have similarly manipulated the boundaries of death to include the “dying”. This paper argues that the redefinition of death debate in biomedicine reveals a concept of personhood which is profoundly western in origin and which is in accordance to the concept adhered to within principlism. Biomedicine and bioethics do not appear to acknowledge the limitations of their own world view and hence lack an understanding of their applicability and appropriateness in diverse social and cultural contexts; a situation which adds credence to claims as to the hegemonic and imperialistic nature of all such global enterprises. Ms. Jones is an intensive care clinical nursing specialist. Dr. Kessel is a public health physician and medical ethicist.     

The ‘Medical Body’ As Philosophy's Arena

Medicine, as Byron Good argues, reconstitutes thehuman body of our daily experience as a medical body,unfamiliar outside medicine. This reconstitution can be seen intwo ways: (i) as a salutary reminder of the extent to which thereality even of the human body is constructed; and (ii) as anarena for what Stephen Toulmin distinguishes as theintersection of natural science and history, in which many ofphilosophy's traditional (and traditionally abstract) questionsare given concrete and urgent form.This paper begins by examining a number of dualities between themedical body and the body familiar in daily experience. Toulmin's epistemological analysis of clinical medicine ascombining both universal and existential knowledge is thenconsidered. Their expression, in terms of attention,respectively, to natural science and to personal history, isexplored through the epistemological contrasts between themedical body and the familiar body, noting the traditionalphilosophical questions which they in turn illustrate.     

God and Contemporary Science: Philip Clayton's Defense of Panentheism

Philip Clayton's God and Contemporary Science is summarized and discussed. Clayton presents a theological reading of biblical texts. In my opinion, science-and-religion studies should deal more substantially with insights of secular studies on the situated character of these texts. Clayton uses the relationship between mind and brain as analogy for the relationship between God and the world. This runs the risk of understanding God as analogous to the mind and hence secondary and emergent relative to the world. Besides, Clayton's arguments for “mental causation” are wanting. But then, why should a defender of panentheism decouple the mental and the material?     

Keeping Up with the Cloneses -- Issues in Human Cloning

The advent of cloning animals has created a maelstrom of social concern about the ethical issues associated with the possibility of cloning humans. When the ethical concerns are clearly examined, however, many of them turn out to be less matters of rational ethics than knee-jerk emotion, religious bias, or fear of that which is not understood. Three categories of real and spurious ethical concerns are presented and discussed: 1) that cloning is intrinsically wrong, 2) that cloning must lead to bad consequences, and 3) that cloning harms the organism generated. The need for a rational ethical framework for discussing biotechnological advances is presented and defended.     

孔子是怎样解释《周易》的

孔子与《易》是有密切关系的,抛开《史记》和帛书的记载不言,仅就《论语》中两条最直接的材料来看确实如此。"加我数年……"当为孔子五十之前所说。五十之前,孔子也曾学《易》,而孔子认为知天命之年尤需学《易》。"不占而已"表明孔子解《易》以德,判定吉凶不需要占筮,而是取决于人的德性。孔子以"生生之德性"解《易》,以"道德必然性"解"天命",通过揭去《周易》的神秘外衣,发掘并发展其天人之学,将隐微难言的性与天道托诸于显著的人道德性,发展出天人合一的德性学说。     

Experiencing the Cross-Sensory Error Signal During Movement Leads to Proprioceptive Recalibration

Abstract

Reaching to targets in a virtual reality environment with misaligned visual feedback of the hand results in changes in movements (visuomotor adaptation) and sense of felt hand position (proprioceptive recalibration). We asked if proprioceptive recalibration arises even when the misalignment between visual and proprioceptive estimates of hand position is only experienced during movement. Participants performed a “shooting task” through the targets with a cursor that was rotated 30° clockwise relative to hand motion. Results revealed that, following training on the shooting task, participants adapted their reaches to all targets by approximately 16° and recalibrated their sense of felt hand position by 8°. Thus, experiencing a sensory misalignment between visual and proprioceptive estimates of hand position during movement leads to proprioceptive recalibration.     

QUANTUM PHYSICS AND THEOLOGY: JOHN POLKINGHORNE ON THOUGHT EXPERIMENTS

Abstract Thought experimentation is part of accepted scientific practice, and this makes it surprising that philosophers of science did not seriously engage with it for a very long time. The situation changed in the 1990s, resulting in a highly intriguing debate over thought experiments. Initially, the discussion focused mostly on thought experiments in physics, philosophy, and mathematics. Other disciplines have since become the subject of interest. Yet, nothing substantial has been said about the role of thought experiments in nonphilosophical theology. This paper discusses the role of thought experiments in Christian theology in comparison to their role in quantum physics, as mentioned by John Polkinghorne in Quantum Physics and Theology. We first look briefly at the history of the inquiry into thought experiments and then at Polkinghorne's remarks about the role of thought experimentation in quantum physics and Christian eschatology. To determine the actual importance of thought experiments in Christian theology a number of new examples are introduced in a third step. In the light of these examples, in a fourth step, we address the question of what it is that explains the cognitive efficacy of thought experiments in quantum physics and Christian theology.     

Delay discounting: I'm a k, you're a k

Delay discounting is the decline in the present value of a reward with delay to its receipt. Across a variety of species, populations, and reward types, value declines hyperbolically with delay. Value declines steeply with shorter delays, but more shallowly with longer delays. Quantitative modeling provides precise measures to characterize the form of the discount function. These measures may be regarded as higher-order dependent variables, intervening variables, or hypothetical constructs. I suggest the degree of delay discounting may be a personality trait. In the end, the ontological status of measures of delay discounting is irrelevant. Whatever delay discounting may be, its study has provided the field of behavior analysis and other areas measures with robust generality and predictive validity for a variety of significant human problems. Research on moderating the degree of delay discounting has the potential to produce substantial societal benefits.