Motor perseverative behavior in adult stutterers and nonstutterers

The performances of 22 adult stutterers and 22 adult nonstutterers on motor tasks requiring the graphic reproduction of a sequence of alternating figures following the production of a series of nonalternating figures were studied. The finding that there were no differences in the performance of the two groups on the alternating motor tasks was interpreted as challenging the validity of previous observations that motor perseverative behavior exists in stutterers and is indicative of a central neurological deficit in that population.     

The confluence model: Parameter estimation for six divergent data sets on family factors and intelligence

Theoretical predictions, based on the confluence model, were made for data from six national surveys of intellectual performance. All six surveys relate intellectual performance scores to family configuration variables. Widely divergent patterns of relationships between the major family factors, such as birth order and family size, and intellectual performance scores characterize the six data sets. Nevertheless, the confluence model was capable of accurate prediction in all cases when all three parameters were estimated. Little accuracy was lost using only two parameters. Variations in the estimated parameter values that reflected the variations in patterns of effects could be meaningfully interpreted for their psychological significance.     

Interpersonal problem solving as a mediator of behavioral adjustment in preschool and kindergarten children

An experimental model tested the mediating function of interpersonal cognitive problem solving skills on behavioral adjustment in preschool and kindergarten children. Relative to controls, nursery-trained youngsters improved in three such skills, kindergarten-trained in two. In both the nursery- and kindergarten-trained groups, increased ability to conceptualize alternative solutions to interpersonal problems significantly related to improved social adjustment. Consequential thinking also emerged as a clear behavioral mediator, especially among kindergarten-aged youngsters. Improvement in behavior could not, however, be attributed to change in causal thinking skills. Having identified two significant behavioral mediators in young children, a beginning has been made to isolate specific thinking skills, which, if enhanced, can contribute to healthy social adjustment and interpersonal competence at an early age.     

Images of the disciplining of psychology, 1890–1940

Over the course of psychology’s first several decades, the language used to convey the subject matter gradually shifted from being free and literary to being strictly constrained and disciplined by increasingly focused theoretical demands. The project described here, “Disciplining Psychology,” aimed to depict this transformation by generating images of the faces of three highly influential psychologists—William James, Sigmund Freud, and B. F. Skinner. Each image is composed of the words used in one of each individual’s most important books. The tightening of the disciplinary vocabulary is revealed in the differences among the three arrays of words themselves, but I have also striven to reflect it in the aesthetic aspects of each image. The method used here could easily be extended to a wider array of authors, texts, and psychological topics.     

慢性乙型肝炎T细胞功能与HBV前C区变异的研究

通过研究慢性HBV感染者前C区变异及T细胞免疫功能与疾病的相关性,评估前C（preC）区变异及T细胞免疫功能对于慢性乙型肝炎（chronichepatitisB,CHB）预后的影响。分别采用实时荧光法、突变特异PCRmsPCR法及微粒酶免疫分析法对150例HBV-DNA阳性的CHB及50例健康体检者进行血清HBV-DN...     

儿童慢性乙型肝炎的抗病毒治疗

儿童慢性乙型肝炎的治疗比较复杂,应正确选择抗病毒治疗的时机,合理应用有限的治疗药物。处于免疫耐受期的患儿不应治疗,处于免疫清除期或肝脏组织学提示有明显炎症的应进行治疗。干扰素是治疗的一线药物,核苷（酸）类似物是二线用药。     

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways.     

Another dragon in the kitchen: Psychological experiences of hepatitis C treatment among HIV‐hepatitis C co‐infected gay men

Background: Increasing numbers of HIV‐infected gay men acquire hepatitis C virus (HCV) co‐infection, which causes serious medical consequences. Treatment for HCV is associated with many severe side effects, in some cases psychological, and many patients subsequently fail to adhere, even when psychological services are utilised, to improve treatment adherence. Objective: This qualitative study aimed to explore the experiences of HIV‐infected gay men undergoing treatment for HCV in order to inform psychological services to better meet specific treatment needs of this population. Methods: Thirteen HIV‐infected gay men who had undergone HCV treatment were interviewed and a qualitative analysis was conducted. Participants described HCV and its treatments in the context of their relationships and lifestyles. Findings: Four domains emerged: HCV diagnosis and treatment; HCV treatment education; change in sense of self; and sexual risk‐taking. Adhering to treatment was a significant challenge for all participants and emerged across all domains. Discussion: Psychological services for this population of co‐infected gay men should assist this clinical population not only with adherence to hepatitis C treatment but should also be available at an earlier stage in the process to help patients make informed choices about whether or not to begin a course of treatment. Assessing factors such as coping strategies, treatment readiness and knowledge, self‐awareness, and level of risk‐taking, can guide clinicians in tailoring treatment and adherence planning for HIV/HCV‐co‐infected gay men.