性激素替代治疗在冠心病防治中的作用

冠心病的发病率有着明显的性别差异,大量研究表明内源性雌激素和雄激素与冠心病的发生发展有着密切关系,它对于女性和男性分别有抗动脉粥样硬化作用,这提示人们可以通过恢复机体激素水平达到防治冠心病的作用。因此性激素替代治疗成为了对冠心病的防治研究的热点,本文主要综述性激素替代治疗在冠心病防治中的研究进展。     

十五年来中国男性择偶标准的变化

对《中国妇女》1985年至2000年15年间每隔5年选择一年,并在每一季度中选择一期杂志,统计男性刊登的征婚启事,总共得到332例。采用统计学方法进行定量研究。发现中国男性在15年间对自身的人品、财产、相貌的重视程度显著增高,对自身的婚史和事业的重视程度明显降低;对女方的持家能力的重视程度显著增高,对女方的健康和工作的重视程度显著降低。当代中国男性的择偶标准随时间的推移有了明显的变化,但仍受到中国传统观念的影响。     

变异性心绞痛患者心率变异性与冠状动脉病变关系的研究

研究变异性心绞痛患者 ST 段抬高对心率变异性的影响。回顾性分析122例变异性心绞痛患者 ST 段抬高幅度及持续时间对心率变异性的影响;心率变异性与冠状动脉病变及病变支数、狭窄程度有相关性。结果心率变异性在 ST 段抬高≥0．4mv 患者中较 ST 段抬高＜0．4mv 患者中明显降低（P＜0．05）;其在 ST 段抬高持续时间≥3min 患者中较 ST 段抬高持续时间＜3min 患者中明显降低（P＜0．05）;其在冠状动脉狭窄≥50％患者中较冠状动脉狭窄＜50％患者中明显降低（P＜0．05）;心率变异性在多支较单支病变明显降低（P ＜0．05）,单支病变狭窄程度≥75％较50％～75％者明显降低（P＜0．05）。提示变异性心绞痛患者自主神经系统受损程度与冠状动脉缺血严重程度,缺血持续时间密切相关,心率变异性能一定程度反映变异性心绞痛患者冠状动脉病变严重程度。     

奥伦自理理论对充血性心力衰竭患者综合生存质量的预后影响研究

研究分析奥伦自理理论对充血性心力衰竭患者综合生存质量的预后影响。选取2012年2月~2013年5月本院收治的90例充血性心力衰竭患者为研究对象,将90例患者遵循随机分配的原则分为对照组（常规护理干预组）45例和观察组（奥伦自理理论组）45例,然后将两组患者护理干预前和护理干预后1个月、3个月的MLHFQ量表、WHOQOL-100量表及Zung量表评估结果进行统计与比较。观察组护理干预后1个月、3个月的MLHFQ量表评分均低于对照组,WHOQOL-100量表评分高于对照组,Zung量表评分与阳性率均低于对照组,P均〈0.05,两组护理干预后的评估结果差异均有统计学意义。奥伦自理理论有助于改善充血性心力衰竭患者的综合生存质量,在此类患者中的应用价值较高。     

Hostility and the clinical course of outpatients with congestive heart failure

Objective: The role of depression and quality of life on clinical outcomes of congestive heart failure (CHF) is well recognised. However, there are fewer studies investigating the prognostic role of subclinical psychological distress and well-being impairments. The aims of this study were to evaluate clinical/subclinical psychological distress and well-being in CHF outpatients, and the influence of these psychological factors on adverse cardiac events (re-hospitalisation, cardiac death), at 4-year follow-up.

Design: Sixty-eight CHF outpatients underwent psychological assessment at baseline and, after 4 years, information about cardiac events was collected in 60 patients by means of clinical records.

Main outcome measures: Psychological assessment included structured clinical interview for DSM (major/minor depression), Interview for diagnostic criteria for psychosomatic research (demoralisation), symptom questionnaire, psychological well-being scales.

Results: At follow-up, 39.7% of the baseline sample reported cardiovascular events (14 CHF-related re-hospitalisations and 13 cardiac deaths) and 5.9% other causes for death. Among the variables examined as potential risk factors for adverse cardiovascular outcomes, only hostility was significant, even after controlling for disease severity (hazard ratio = 2.38, 95%confidence interval: 1.04–5.45, p = .040).

Conclusion: In outpatients with CHF, psychological assessment should include both clinical and subclinical distress such as hostility, in order to better address psychological risk factors for cardiac outcomes.     

Springs,Nitre, and Conatus. The Role of the Heart in Hobbes's Physiology and Animal Locomotion

This paper focuses on an understudied aspect of Hobbes's natural philosophy: his approach to the domain of life. I concentrate on the role assigned by Hobbes to the heart, which occupies a central role in both his account of human physiology (which he names ‘vital motion’) and of the origin of animal locomotion (‘animal or voluntary motion’). With this, I have three goals in mind. First, I aim to offer a cross-section of Hobbes's effort to provide a mechanistic picture of human life. Second, I aim to contextualize Hobbes's views in the seventeenth-century debates on human physiology and animal locomotion. In particular, I will compare Hobbes's views with the theories put forth by Harvey, Descartes, the Galenic, and Peripatetic traditions. Also, I will show that Hobbes was receptive to advances within contemporary English physiology and chemistry. Third, by means of a comparison with Descartes, I advance some hypothesis to explain why Hobbes indentified the heart, and not the brain (as was increasingly common in his day), as the organ originating animal locomotion. In this regard, I trace out some possible implications of Hobbes's views on human physiology and locomotion for his psychology and political philosophy.     

Psychological and autonomic effects of art making in college-aged students

Background and objectives: Anxiety disorders comprise the most common category of mental illness among US young adults. Art making might be one method to help reduce anxiety, but the few studies investigating this have used only subjective measures of anxiety. Design: This study employed both subjective (self-reported state anxiety from the State-Trait Anxiety Inventory) and objective (heart rate variability) measures to assess whether 30-minute periods of art making reduced anxiety in 47 first-year college students prior to their final examinations. Methods: Students participated in free-form painting, mandala coloring, clay modeling, and control sessions. Results: Repeated-measures ANOVA with post hoc analysis revealed significantly greater pre- to post-session reductions in anxiety for all three types of art-making sessions than for the control session, as measured objectively. Measured subjectively, only free-form painting yielded a significant decrease in anxiety compared to the control session. Conclusions: Given the health benefits of anxiety reduction, further study is warranted to determine the duration of art making's anxiety-reducing effect.     

Prenatal origins of temperament: Fetal cardiac development & infant surgency,negative affectivity,and regulation/orienting

Temperament, i.e. individual differences in reactivity and self-regulation, emerges early in infancy; might temperament originate during fetal development? Mixed findings and methodological issues in the literature examining this consideration limit our understanding of the continuity between these fetal indices and infant temperament. The primary aims of the current study were to improve on published studies by (a) using standardized and well-accepted fetal cardiac (actocardiograph) and infant temperament measures (the Infant Behavior Questionnaire—Revised; IBQ-R) (b) expanding fetal assessments to include coupling (the cross correlation of heart rate with movement), and (c) examining a diverse sample to determine if findings of associations between fetal neurobehavior and infant temperament generalize beyond cohorts that are demographically well-resourced and predominantly white. Building on theory and empirical findings, we hypothesized that (1) FHR would be positively associated with Surgency and Negative Affectivity, (2) FHRV would be positively associated with Surgency, and Regulation/Orienting and inversely associated with Negative Affectivity, and (3) fetal coupling would be positively associated with Regulation/Orienting and Surgency and inversely associated with Negative Affectivity. We collected 20 min of fetal data (m gestational age = 34.42 weeks) and mothers completed the IBQ-R (n = 90 women; 60 % non-Caucasian race; 63 % Latina ethnicity). We found that FHR was positively associated with Negative Affectivity but not associated with Surgency (or Regulation/Orienting). FHRV was inversely associated with Surgency but not associated with Negative Affectivity or Regulation/Orienting. Coupling was positively associated with Regulation/Orienting and Surgency but not associated with Negative Affectivity. Our findings, from a more diverse sample and with established measures, provide further evidence that individual differences in reactivity and regulation can be identified in the in-utero period and show theory-based continuity to specific infant temperament constructs.     

Stressing the feedback: attention and cardiac vagal tone during a cognitive stress task

Objectives: The present study examined relationships among gaze behaviour and cardiac vagal tone using a novel stress-inducing task.

Methods: Participants’ (N?=?40) eye movements and heart rate variability (HRV) were measured during an unsolvable computer-based task randomly presenting feedback of “Right” and “Wrong” answers distinctly onscreen after each trial. Subgroups were created on the basis of more frequent eye movements to the right (“Correct”-Attenders; n?=?23) or wrong (“Incorrect”-Attenders; n?=?17) areas onscreen.

Results: Correct-Attenders maintained HRV from baseline to the stress task. In contrast, Incorrect-Attenders spent significantly more time viewing “Wrong” feedback, exhibited a reduction in HRV during the stress condition (p?Conclusions: Results demonstrate that pervasive attention to negative feedback (“Wrong”) elicits perseverative stress and negative self-evaluations among university students. This study highlights the potential for studying attentional biases and emotional distress through combined measures of gaze behaviour and cardiac vagal tone.