纳米细菌与冠心病

最近新发现的纳米细菌是目前已知的最小的细菌,其直径为几十至几百纳米.与其它细菌不同,它们是一种生长繁殖缓慢,能通过普通滤菌器(0.2um),吴有生物矿化作用和一定抗辐射能力,革兰氏染色阴性的球形细菌.它们最特殊的生物学特性是可以在生理状态的钙、磷浓度下分泌主要由羟磷石灰碳酸盐构成的保护性外壳.因此,它们被认为与机体内病理性钙化密切相关.近年来研究发现,它们可能是冠心病的一种感染性致病源.抗纳米细菌治疗的临床实验显示在冠心病患者中具有一定疗效.     

Caregiver Social Problem Solving Abilities and Family Member Adjustment Following Congestive Heart Failure

Family members have a considerable impact on the health and well-being of others in the family. The characteristics of family caregivers that relate to care recipients' positive and negative outcomes associated with chronic disease have received scant empirical attention. We reasoned that family caregiver social problem solving abilities would be associated with depression and life satisfaction reported by persons with congestive heart failure (CHF). Correlational analyses found that caregiver negative orientation toward solving problems was significantly predictive of higher depression and with decreased life satisfaction of persons with CHF. These findings indicate that family caregiver problem solving abilities are important factors in adjustment following CHF. Implications for clinical interventions and theoretical models of problem solving are discussed.     

Compassion at the mirror: Exposure to a mirror increases the efficacy of a self-compassion manipulation in enhancing soothing positive affect and heart rate variability

We tested whether a mirror could enhance the efficacy of a self-compassion manipulation in increasing soothing positive affect and heart rate variability (HRV). Eighty-six participants generated four phrases they would use to soothe and encourage their best friend. Second, they described an episode where they criticized themselves and were assigned to one of three conditions: (a) repeat the four phrases to themselves while looking at the mirror; (b) repeat the four phrases to themselves without the mirror; (c) look at themselves in the mirror without repeating the phrases. Participants in condition (a) reported higher levels of ‘soothing’ positive affect and HRV compared to participants in conditions (b) and (c). The effect of the ‘phrases at the mirror’ manipulation on soothing affect was mediated by increased common humanity. The mirror enhances the efficacy of this self-compassion manipulation in activating the soothing affect system connected with parasympathetic nervous system activity.     

特里尔社会应激测试(TSST)对唾液皮质醇分泌的影响

特里尔社会应激测试(Trier Social Stress Test: TSST)是国外应用广泛的社会心理应激测试手段, 然而还没有研究对其在中国的适用性进行报告。本研究以健康大学生为被试, 分别采用主观应激报告(简明心境量表和5点量表)和客观应激参数(心率和唾液皮质醇)为指标, 探讨TSST在中国的适用情况以及性别因素对个体在TSST应激情境中的影响。结果发现, TSST诱发了中国被试显著的应激反应, 在经历了TSST情境后, 被试主观报告紧张水平增加, 同时心跳加速, 唾液皮质醇水平增加。即使女性被试主观报告紧张与不安的程度显著高于男性, 但是男性和女性在TSST应激情境下的心跳和唾液皮质醇指标没有差异。研究结果提示, TSST在中国被试中具有良好的适用性, 可以利用其开展与社会心理应激相关的研究。男女被试在与成就动机相关的应激源(例如, TSST)中的客观应激参数差异不明显。     

Reward Influence on the Heart: Cardiovascular Response as a Function of Incentive Value at Five Levels of Task Demand

This study examined cardiovascular effects of incentive value in men and women confronted with cognitive challenges that were more and less difficult to meet. Participants performed computer memory tasks varying in difficulty from low to high, with instructions that they could earn chances toward a $100 prize or $10 prize by attaining a 90% success rate. Analysis of cardiovascular responses assessed during work revealed an interaction between difficulty and incentive value for heart rate. Participants' heart rate responses were proportional to task difficulty and unaffected by incentive value in all conditions except for the most difficult one. Where difficulty was greatest, $100 participants showed relatively high heart rate responsiveness, whereas $10 participants showed low heart rate responsiveness. This heart rate finding corroborates and extends cardiovascular results from previous experiments, and lends further support to the view that cardiovascular responses will be proportional to incentive value only under some task conditions.     

β-受体阻滞剂治疗慢性心力衰竭的哲学发展观

随着科学技术的快速发展和人们认识的不断深入,慢性心力衰竭（CHF）的发病机制处于不断嬗变的过程,CHF的药物治疗概念也发生了根本性的变化。β-受体阻滞剂在CHF的治疗策略中,经历了从禁用到必用的过程,成为了CHF药物治疗的重大突破。大量临床试验表明,β-受体阻滞剂不仅能改善患者预后,而且能明显改善左室的舒张和收缩功能,全面改善患者的血流动力学,提高患者的运动耐量和生活质量,延长生存时间。β-受体阻滞剂在CHF治疗中地位的变化,体现了哲学发展观与疾病的治疗以及药物应用的紧密联系,指导着我们的临床实践,也体现了哲学与自然科学的密切联系。本文将β-受体阻滞剂治疗CHF的新旧观念进行阐述、比较,对其作用机制以及临床用药进行介绍,并对其发展空间进行展望。随着科学的进步,人类有能力从长远的角度控制疾病。     

心率变异性在心身疾病和情绪障碍研究中的应用

心率变异性的频谱成分可单独反映交感神经和副交感神经活动的影响。高频（HF）是由迷走神经单独介导；低频（LF）受迷走神经和交感神经共同调制，但主要反映交感神经的活动性 。此指标可对高血压、冠心病和月经前期烦躁等心身障碍进行评价。该文还探讨了它用于情绪研究的价值，并认为在不同情绪体验期间的自主神经活动有多种搭配模式，正常人与情绪障碍者之间以及情绪障碍（抑郁、焦虑、恐怖、强迫）患者在自主神经活动方面可能存在显著差别     

认知评价对主观情绪感受和生理活动的作用

围绕认知评价对情绪的作用, 针对传统认知评价实验方法的缺陷, 本研究改进认知评价的操作方法, 以情绪片段为实验材料, 以事先的评价背景替代与观看同步的评价策略, 以生理指标与情绪自评反映情绪变化, 考察41名大学生的认知评价对负性情绪的影响。结果发现, 持有利于情绪调节评价的个体, 负性情绪感受降低, 皮肤电反应减弱, 但心率无变化。研究表明, 认知评价影响个体的主观情绪体验, 并在一定程度上抑制负性情绪所致的生理唤起的增高。     

亚临床甲状腺功能减退与冠状动脉粥样硬化性心脏病

对冠心病高危因素积极地预防及治疗,可降低冠心病的患病率和病死率。已经得到公认的临床甲状腺功能减退通过引起代谢及血流动力学紊乱而参与了冠状动脉粥样硬化的发生与发展。目前,国内外许多临床研究显示亚临床甲状腺功能减退通过多种途径参与冠心病的发生和发展,是冠心病的重要危险因素之一。     

负性情绪抑制对社会决策行为的影响

利用心理生理实验法, 通过将情绪抑制操作引入最后通牒博弈实验范式, 探讨负性情绪抑制的主观情绪体验、生理反应及其对社会决策行为的影响。以40名大学生为被试, 采用MP150型16导生理记录仪记录皮肤电反应和心率。实验为2 (组别：情绪抑制组、自然观看组) × 2 (性别：男、女) × 2 (博弈对手：人、计算机) × 4 (分配方案：￥5：￥5、￥7：￥3、￥8：￥2、￥9：￥1)的混合设计, 其中组别和性别为被试间因素, 博弈对手和分配方案为被试内因素。结果发现：(1)对负性情绪进行抑制没有减少被试相应的主观体验, 情绪抑制使皮肤电反应性增强; (2)负性情绪抑制的主观体验和生理反应不存在性别差异; (3)在面对不公平的分配方案时, 情绪抑制组被试比自然观看组更倾向于拒绝接受。结果表明在最后通牒博弈中,情绪抑制影响回应者的行为反应,使他们更倾向于做出不理智的决策。