ES、iNOS及bFGF在桥本氏甲状腺炎中表达的研究

采用S-P法检测17例HT患者甲状腺组织切除标本和9例正常甲状腺组织标本中ES、iNOS及bFGF的表达并分析其之间的相关性,以探讨三者在HT发生发展中的作用。结果HT组中ES、iNOS及bFGF的表达程度均明显高于正常组（P均〈0.05）,其中ES与bFGF表达无显著相关性（P〉0.05）,ES与iNOS、bFGF与iNOS的表达均呈显著正相关（r=0.531,r=0.723,P均〈0.05）。结论为在HT中,高表达的ES、iNOS及bFGF在其发生和发展中可能具有重要作用,为研究其病理生理变化和发病机理提供了理论依据。     

肝细胞生长因子受体在胶质母细胞瘤术后放疗过程中的价值评价

为了探讨脑胶质母细胞瘤术后放疗对肝细胞生长因子受体表达规律的影响,对25例胶质母细胞瘤患者进行研究。结果显示肝细胞生长因子受体在复发前接受放疗与未接受放疗的患者中,复发后肝细胞生长因子受体表达及复发时间差异明显（P〈0．05）。因此放疗能对肝细胞生长因子受体在胶质母细胞瘤的表达产生影响,进而影响到其复发时间。     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子（vascular endothelial growth factor,VEGF）是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一。结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出。本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述。     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子(vascular endothelial growth factor,VEGF)是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一.结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出.本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述.     

Frequency trajectory effects in Chinese character recognition: Evidence for the arbitrary mapping hypothesis

Frequency trajectory is a better measure to investigate age-limited learning effects than age of acquisition (AoA) ratings (Zevin, J. D., & Seidenberg, M. S. (2002). Age of acquisition effects in word reading and other tasks. Journal of Memory and Language, 47(1), 1-29). The current study uses frequency trajectory as a variable to investigate age-limited learning effects in Chinese character recognition, and tests predictions of the arbitrary mapping hypothesis as applied in a non-alphabetic writing system. In Experiment 1, regression analyses showed that, compared to rated AoA, frequency trajectory of characters was less affected by other lexical properties, and could explain a significant proportion of variance of AoA. In Experiment 2, the frequency trajectory and predictability from orthography to pronunciation of characters were orthogonally manipulated in a character naming task. The frequency trajectory effect appeared only for the arbitrary mapping condition. In Experiment 3, frequency trajectory and predictability from orthography to meaning of characters were manipulated in a semantic category judgment task. The frequency trajectory effects were found only when the mapping from orthography to semantic is less consistent. In summary, the study confirmed that AoA is a genuine factor affecting word processing, and the AoA effects were limited to those situations in which mapping between input and output representation was arbitrary. These results provide strong cross-linguistic evidence in support of the arbitrary mapping hypothesis.     

Daily mood patterns and bulimic behaviors in the natural environment

Objective

Negative affect has been purported to play an important role in the etiology and maintenance of bulimic behaviors. The objective of this study was to identify daily mood patterns in the natural environment exhibited by individuals with bulimia nervosa and to examine the relationship between these patterns and bulimic behaviors.

Method

One hundred thirty-three women aged 18-55 meeting DSM-IV criteria for bulimia nervosa were recruited through clinical referrals and community advertisements. Ecological momentary assessment was used to collect multiple ratings of negative affect, binge eating and purging each day for a two-week period using palmtop computers. Latent growth mixture modeling was used to identify daily mood patterns.

Results

Nine distinct daily mood patterns were identified. The highest rates of binge eating and purging episodes occurred on days characterized by stable high negative affect or increasing negative affect over the course of the day.

Conclusions

These findings support the conclusion that negative mood states are intimately tied to bulimic behaviors and may in fact precipitate such behavior.     

Acute systemic fibroblast growth factor-2 enhances long-term memory in developing rats

Recent findings have provided much insight into the mechanisms underlying long-term memory formation, and it is now known that long-term memory depends on the activation of a molecular cascade that culminates with structural changes in the brain. However, little is known about the signals that give rise to or regulate these structural changes. In this article we propose that fibroblast growth factor-2 (FGF2), a mitogen for several cell types, may be one of the molecular signals critically involved in the structural changes underlying long-term memory. If FGF2 is part of the signalling cascade involved in long-term memory, then increasing the activation of FGF2 should facilitate memory. In Experiments 1 and 2, we demonstrated that systemic injection of FGF2 (20 ng/g of body weight) facilitated memory for contextual fear in 16, 19, and 22 day old male Sprague Dawley rats. Experiment 3 demonstrated that the observed facilitation of memory was not due to FGF2 increasing rats’ sensitivity to footshock. These results implicate FGF2 as a possible molecular signal in long-term memory, and further, illustrate a novel means of enhancing memory.     

Normative Developmental Trajectories of Aggressive Behaviors in African American,American Indian,Asian American,Caucasian, and Hispanic Children and Early Adolescents

The current 5-year accelerated longitudinal investigation modeled the developmental trajectories of aggressive behaviors in 10,107 predominantly minority (>70%; African American, American Indian, Asian American, and Hispanic) children and early adolescents (Kindergarten through 8th grade, 49% female youth) from lower to lower-middle socioeconomic strata. Based on a two-part latent growth model, findings suggest that the probability and frequency of aggressive behavior use decreases slightly (linear) through the elementary school years and then increases as children move into middle school (quadratic). Though mean level differences were found across ethnic and racial groups, socioeconomic strata, and particularly by sex at initial status, rates of change over time across all groups were invariant. Findings suggest that potential socialization differences, if any, occur pre-Kindergarten in all groups.     

入学过渡期高中新生大五人格与主观社会地位变化轨迹的关系：基于潜变量增长模型的分析

为了考察入学过渡期高中新生主观社会地位（subjective social status, SSS）的变化轨迹及人格在其中的作用,本研究对546名高一新生进行了历时4个月的4次追踪测试。基于潜变量增长模型的分析结果显示：（1）SSS呈阶段化线性增长,且个体间差异显著;（2）人格中的外倾性、宜人性、责任心和开放性均能显著预测SSS的初始水平;（3）外倾性、宜人性和神经质对SSS的第一阶段变化速度有显著预测作用。结果表明,SSS会在新生入学后1个月内初步形成,且人格与其变化轨迹有关。