A latent variables examination of processing speed, response inhibition, and working memory during typical development

This study addressed three related aims: (a) to replicate and extend previous work regarding the nonunitary nature of processing speed, response inhibition, and working memory during development; (b) to quantify the rate at which processing speed, response inhibition, and working memory develop and the extent to which the development of these latter abilities reflect general changes in processing speed; and (c) to evaluate whether commonly used tasks of processing speed, response inhibition, and working memory are valid and reliable when used with a developmentally diverse group. To address these aims, a latent variables approach was used to analyze data from 147 participants 6-24 years of age. Results showed that processing speed, response inhibition, and working memory were separable abilities and that the extent of this separability was stable across the age range of participants. All three constructs improved as a function of age; however, only the effect of age on working memory remained significant after processing speed was controlled. The psychometric properties of tasks used to assess the constructs were age invariant, thereby validating their use in studies of executive development.     

Grain boundary phase observed in Al–5 at.% Zn alloy by using HREM

The nature and behaviour of grain boundary (GB) phases is very important since they can control strength, plasticity, resistivity, grain growth, corrosion resistance, etc, especially in nanocrystalline materials. For nanocrystalline Al-based light alloys, extremely high plasticity has been observed in restricted temperature and concentration intervals close to the solidus line. This phenomenon is not fully understood. It can be explained by formation of GB phases not included in the bulk phase diagram. Therefore, the structure of GB phases, as well as thermodynamic conditions for their existence, has to be carefully studied. In this work the structure and composition of GBs and GB triple junctions in Al–5 at.% Zn polycrystals annealed in the temperature region above and below the bulk solidus line were studied by high-resolution electron microscopy and analytical transmission electron microscopy. Evidence has been obtained that a thin layer of a liquid-like phase exists in GBs and GB triple junctions slightly below the bulk solidus line.     

Misorientation characteristics of penetrating morphologies at the growth front of abnormally growing grains in aluminum alloy

The initial stage of abnormal grain growth of the aluminum alloy 5052 has been investigated using electron back-scattered diffraction to analyze the characteristic of misorientations of the penetrating morphology at the growth front. Among the 84 penetrating morphologies examined, none of the penetrated grain boundaries has low angles or coincidence site lattice (CSL) relations, whereas 66 penetrating grain boundaries have low angles or CSL relations. These results strongly suggest that the penetrating morphologies should result from triple-junction wetting.     

贝伐单抗治疗实体肿瘤的临床研究进展

血管内皮生长因子(vascular endothelial growth factor,VEGF)在肿瘤的发病机制中起着关键作用,其作为抗肿瘤治疗的重要靶点,已得到越来越多的关注.贝伐单抗(Bevacizumab,BEV)是一种血管内皮生长因子的单克隆抗体,是目前最受关注的分子靶向药物之一,自2004年经美国FDA批准上市以来,BEV已被用于多种实体肿瘤的治疗.本文就BEV关于治疗几类实体肿瘤的临床研究进展作一综述.     

Responses to the September 11, 2001, Terrorist Attacks: Experience of an Indirect Traumatic Event and Its Relationship With Perceived Benefits

Little is known about how people might benefit from an indirectly experienced traumatic event. The authors examined the relationship between perception of benefit and trauma symptoms in response to a relatively severe, but indirectly experienced, traumatic event. The authors sampled from 2 colleges located in the southeastern United States (N = 136). Individuals responded to questionnaires that assessed perceived benefits and trauma symptoms 1-2 weeks after the terrorist attacks of September 11, 2001, and again approximately 10 weeks later. Participants did perceive benefits from witnessing this event, although their perception of benefit declined over time. Level of trauma symptoms correlated positively with perception of benefit, and experiencing a previous trauma also correlated positively with perceived benefits. Additional analysis indicated that level of trauma symptoms mediated the relationship between previous trauma and perception of benefit. These findings help to elucidate understanding of the development of perceived benefits in response to indirectly experienced events.     

A tutorial on adaptive design optimization

Experimentation is ubiquitous in the field of psychology and fundamental to the advancement of its science, and one of the biggest challenges for researchers is designing experiments that can conclusively discriminate the theoretical hypotheses or models under investigation. The recognition of this challenge has led to the development of sophisticated statistical methods that aid in the design of experiments and that are within the reach of everyday experimental scientists. This tutorial paper introduces the reader to an implementable experimentation methodology, dubbed Adaptive Design Optimization, that can help scientists to conduct “smart” experiments that are maximally informative and highly efficient, which in turn should accelerate scientific discovery in psychology and beyond.     

Post‐Traumatic Growth and Optimism as Outcomes of an Internet‐Based Intervention for Complicated Grief

This explorative study examines the effects of an internet‐based cognitive‐behavioural therapy for complicated grief on post‐traumatic growth and optimism. The study is part of a larger randomized controlled trial described in Wagner, Knaevelsrud, and Maercker (2006) Wagner, B., Knaevelsrud, C. and Maercker, A. 2006. Internet‐based cognitive‐behavioral therapy for complicated grief: a randomized controlled trial.. Death Studies, 30: 429–453. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]. The patients were randomly assigned to either a treatment group (n = 26) or a waiting list control condition (n = 25). The internet‐based intervention consisted of exposure to bereavement cues, cognitive reappraisal exercises, and a module on integration and restoration. A short form of the Post‐traumatic Growth Inventory (PTGI), the Life Orientation Test‐Revised (LOT‐R), and measures of complicated grief and psychopathological outcomes were administered. Results indicate that post‐traumatic growth increased in the treatment group. No treatment effect was found for optimism. These findings contribute to the growing literature on personal growth in psychotherapy.     

A computational account of the development of the generalization of shape information

Abecassis, Sera, Yonas, and Schwade (2001) showed that young children represent shapes more metrically, and perhaps more holistically, than do older children and adults. How does a child transition from representing objects and events as undifferentiated wholes to representing them explicitly in terms of their attributes? According to RBC (Recognition‐by‐Components theory; Biederman, 1987 ), objects are represented as collections of categorical geometric parts (“geons”) in particular categorical spatial relations. We propose that the transition from holistic to more categorical visual shape processing is a function of the development of geon‐like representations via a process of progressive intersection discovery. We present an account of this transition in terms of DORA ( Doumas, Hummel, & Sandhofer, 2008 ), a model of the discovery of relational concepts. We demonstrate that DORA can learn representations of single geons by comparing objects composed of multiple geons. In addition, as DORA is learning it follows the same performance trajectory as children, originally generalizing shape more metrically/holistically and eventually generalizing categorically.     

An Exercise in Psychological Growth*

The author presents a case report followed by a self- assessment exercise which was generated spontaneously in collaboration with the patient herself during the treatment process. The lists of questions, designed to provoke thought and stimulate maturation, were found to be quite helpful especially in making important life decisions. It is proposed as a learning tool and template for use by those confronting similar issues. Lois Gerby, MA, is a psychologist and family therapist in private practice, 32 Hapalmach St., Suite 32/7, Jerusalem, Israel 92542 (jack.friedman@mail.mcgill.ca). *Translation by Yacov Friedman and Haim Sherrf.     

Three Educational Orientations: A Peircean Perspective on Education and the Growth of the Self

The theme of growth is amongst the most important and pervasive themes in the philosophy of Charles Peirce. This paper offers a synthesized account of the Peircean self drawn from his various discussions of the growth of ideas and then presents three educational orientations which, in turn, tend to foster or frustrate this growth. It concludes that the growth of the student depends significantly upon the ends or intent of the educator and upon an appropriate mean between freedom and constraint in the educational context. A commitment to such an orientation is taken to be a form of resistance to the narrowing ends of business-minded educational institutions