晚期非小细胞肺癌TKIs治疗：关注与思考

以表皮生长因子受体（EGFR）为靶点的酪氨酸激酶抑制剂（TKIs）对晚期非小细胞肺癌EGFR突变患者的治疗效果令人瞩目。本文分析总结近年国内外相关研究,指出低剂量TKIs的应用虽有待进一步证实,但优于标准剂量组,并从安全性、改善肿瘤血管结构和功能、与细胞毒化疗的关系三方面探讨大剂量TKIs的应用效果。进一步分析指出大剂量联合小剂量TKIs能够最大程度地防止或延迟耐药的发生,进而控制疾病的进展。从而,为晚期非小细胞肺癌EGFR突变患者的TKIs治疗选择提供参考。     

Longitudinal trajectories of emotions among athletes in sports competitions: Does emotional intelligence matter?

ObjectivesThis research explored whether several subgroups of athletes representing distinct emotional trajectories could be shown to exist within the latent class growth analysis (LCGA) of pleasant and unpleasant sport emotions (anger, anxiety, dejection, excitement, happiness). A secondary aim was to explore whether athletes belonging to distinct emotional trajectories reported distinct scores of trait-emotional intelligence (EI) at time 1 (T1).DesignA longitudinal three-wave measurement design (beginning, middle, and end of a competitive season) was used in the present study.MethodA sample of 460 athletes completed the sport emotion questionnaire across three measurement times and the brief emotional intelligence scale at T1.ResultsResults of LCGAs showed five trajectories for anger, anxiety and happiness, and six trajectories for dejection and excitement. Furthermore, athletes belonging to distinct (adaptive or maladaptive) trajectories reported significantly different scores of EI.ConclusionsLCGA results highlighted the athlete heterogeneity in longitudinal sport emotions. Higher scores of EI were reported by athletes belonging to adaptive emotional trajectories. These results could be used to help coaches and sport psychologists to identify athletes at risk of developing dysfunctional emotional trajectories across the competitive season. Moreover, this study suggested potential benefits of EI-centred interventions to help athletes to experience adaptive emotional trajectories. Finally, these results highlighted that heterogeneity in sport emotions must be accounted for in future research.     

国内追踪数据分析方法研究与模型发展

追踪研究因其可以得到比横断研究更有说服力的变量关系论证, 在心理学等科学中具有重要地位。梳理国内以心理学为主的相关领域中追踪数据分析方法研究的发表现状、主要解决的研究问题和模型发展。追踪研究可以进行均值差异比较、分析多变量相互影响、描述总体发展趋势及差异和探究心理动态变化过程。近20年的研究热点和发展思路也集中在上述研究问题当中, 特别是总体发展趋势及差异、多变量相互影响、总体发展趋势与多变量相互影响的融合、追踪研究设计、缺失数据等议题上。最后, 比较国内外研究的差异, 并结合交叉学科对国内追踪研究未来发展做出展望。     

成长型思维与坚毅的关系:未来时间洞察力和成就动机的链式中介作用

以山东地区两所高校的548名大学生为研究样本,采用问卷调查法收集数据,考察未来时间洞察力和成就动机在大学生成长型思维与坚毅之间的链式中介效应。结果显示：（1）成长型思维、未来时间洞察力、成就动机与坚毅之间均存在显著正相关;（2）成长型思维既能通过未来时间洞察力和成就动机分别间接预测大学生的坚毅品质,又能通过未来时间洞察力→成就动机的链式中介作用间接预测大学生的坚毅品质。     

Latent classes of posttraumatic stress and growth

Background and Objectives: Potentially traumatic events may lead to different patterns of posttraumatic stress symptoms and posttraumatic growth. The objective of the present study was to identify subgroups with different patterns of posttraumatic reactions, and to determine whether these subgroups differed in terms of personal and social resources and indicators of adjustment. Design: This study used survey data collected 10 months after the 2011 Oslo bombing attack to investigate patterns of reactions among ministerial employees (N = 1970). Methods: We applied latent class analyses with covariates to extract subgroups of individuals. Results: Three classes of individual reactions were extracted, and these were similar among those who were and those who were not physically proximate to the bombing attack: “High stress/high growth” (27% and 11%, respectively), “Low stress/high growth” (74% and 42%, respectively), and “Low stress/low growth” (only among the not physically proximate: 47%). The classes differed in terms of gender, neuroticism, and social support as well as life satisfaction and daily functioning. Conclusions: Heterogeneous patterns of posttraumatic reactions were found. Physical proximity is not necessary to experience posttraumatic stress or growth after political violence. Among individuals with low stress, posttraumatic growth may not encompass higher life satisfaction or functioning.     

学校资源对青少年早期幸福感发展的影响：意向性自我调节的纵向中介作用

通过对1214名初中生历时3年的3次追踪测量,考察了青少年早期的学校资源、意向性自我调节及幸福感的发展趋势,并对意向性自我调节在学校资源与幸福感发展间的纵向中介作用机制进行检验。结果发现,在青少年早期,学校资源具有相对的稳定性,意向性自我调节及幸福感均呈线性增长;学校资源对幸福感发展的作用机制表现为:一方面,学校资源通过意向性自我调节的初始水平分别对幸福感的初始水平和发展速度起间接作用,另一方面,学校资源通过意向性自我调节的发展速度对幸福感的发展速度起间接作用。结论:青少年早期,学生的学校资源水平保持稳定,意向性自我调节和幸福感的发展均呈线性递增趋势;学校资源能够通过意向性自我调节的初始水平和发展速度对幸福感的发展起间接作用。     

Application of the Bons–Azuma method and determination of grain growth mechanism in rolled Ti–Zr alloys

Zr-containing Ti alloys have widely been developed owing to the infinite solid solubility of Zr in Ti and its avirulence, leading respectively to high strength and good biocompatibility. It is known that the Zr addition gives rise to grain refinement when rolled Ti–Zr alloys are annealed; nevertheless, the governing mechanism by which Zr addition in Ti can reduce grain size is not fully understood. In this study, the grain growth behaviour of rolled Zr-free and Zr-containing (Ti–10Zr, wt.%) alloys is analysed using analytical transmission electron microscopy and the classical and Bons–Azuma methods by evaluating the grain growth exponent. Irrespective of the evaluation technique and Zr content, the grain growth exponent is found to be close to ~0.3, indicating the occurrence of normal grain growth in the Zr-free alloy and solute drag mechanism in the Zr-containing alloy. It is found that the grain size and grain growth rate are significantly reduced by Zr segregation near grain boundaries, resulting from the solute drag mechanism.     

From a state to a trait: Trajectories of state mindfulness in meditation during intervention predict changes in trait mindfulness

Theory suggests that heightening state mindfulness in meditation practice over time increases trait mindfulness, which benefits psychological health. We prospectively examined individual trajectories of state mindfulness in meditation during a mindfulness-based intervention in relation to changes in trait mindfulness and psychological distress. Each week during the eight-week intervention, participants reported their state mindfulness in meditation after a brief mindfulness meditation. Participants also completed pre- and post-intervention measures of trait mindfulness and psychological symptoms. Tests of combined latent growth and path models suggested that individuals varied significantly in their rates of change in state mindfulness in meditation during the intervention, and that these individual trajectories predicted pre-post intervention changes in trait mindfulness and distress. These findings support that increasing state mindfulness over repeated meditation sessions may contribute to a more mindful and less distressed disposition. However, individuals’ trajectories of change may vary and warrant further investigation.     

Religious Doubt and Spiritual Growth Among Adults Bereaved of a Grandparent

Religious beliefs and bereavement provide contexts for personal growth (Benore & Park, 2004). The death of a grandparent may be especially well-suited to prompt such growth. Using data from 164 adults, ages 18 to 51 years, bereaved of a grandparent, the authors examined whether religious doubt relates to current grief via perceived spiritual growth. Mediation analyses showed that fewer religious doubts were associated with spiritual growth in bereavement, but spiritual growth was associated with higher levels of current grief. Results are discussed within a framework for including family processes in bereavement research that includes religious doubt and spiritual growth.