AIDS: Globalization and Its Discontents

Abstract. HIV/AIDS has changed from a disease of white gay men in the United States to a pandemic that largely involves women and dependent children in developing countries. Many theologies of disease are necessary to cope with the variety of expressions of this pandemic. Christian theoethical reflection on HIV/AIDS has been largely focused on sexual ethics, with uneven and mainly unhelpful results. Among the ethical issues that shape future useful conversations are globalized economics and resource sharing, the morality and economics of the pharmaceutical industry, and the need for sex education and access to reproductive choice. Considering such issues in international, interreligious, multiscientific contexts is a concrete next step for the religion‐and‐science dialogue. It will put the powerful tools of both fields to the service of the common good.     

对流行病学本科教材中病因推断的部分方法的质疑

全国高等医药院校教材第五版<流行病学>,在讲述病因研究的推理方法时,介绍了求因果联系的5种方法.但其中的求异法和同异并用法及其举例是错误的.     

Functional imaging of working memory and peripheral endothelial function in middle-aged adults

The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β = 0.338, p = 0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36) = 2.66, p = 0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.     

2009年贵阳市住院儿童手足口病病原学及临床特点

为了解贵阳地区2009年4月~9月儿童手足口病的病原学及临床特点。从住院的820例手足口病患儿中采集部分伴有重症倾向的244例患儿的肛试子和咽试子标本进行RT-PCR技术检测,并进行临床观察。218例检测到肠道病毒,占89.34%,其中138例为EV71,占63.30%。72例为CA16,占33.02%,两者之比1.92:1。不同年龄组的病原构成差异有统计学意义(P0.01)。重症病例EV71感染明显高于轻症病例,两者在临床特征方面差异有统计学意义(P0.01)。2009年贵阳市住院儿童手足口病的主要病原是EV71和CA16;1岁~3岁的患儿EV71感染明显高于CA16,EV71比CA16更易引重症手足口病,重症病例与轻症病例在临床表现上有明显差异。     

左主干或多支冠脉病变的选择:PCI或CABG?

近年来,PCI技术越来越多地实践于左主干和多支冠脉病变,但与CABG相比,其疗效一直受到质疑。本文对近年来PCI和CABG的疗效比较做一总结,发现对于左主干和冠脉多支病变,CABG仍优于PCI。但随着生产力水平的发展和社会需求越来越高的双重作用下,两项技术都必然会有新的发展,两者疗效的比较还会继续,我们将拭目以待。     

我国酒精性肝病的医学困惑与应对策略

酒精性肝病是导致我国肝脏损害的第二大原因,已成为最严重的健康问题之一。我国已经迎来了酒精性肝病的高峰时期,并将会持续增长,卫生系统将面临巨大的压力。然而,对于酒精性肝病本身,还存在着诊断、治疗、预防等众多医学困惑;饮酒的危害不仅仅局限在肝脏,还可引起全身多器官的损害;酒害也早已超越了医疗界,是一个严重的社会问题。对于酒精性肝病的防治需要全社会共同参与,并且将是一条极其漫长而艰难的路程。     

Keeping the vermin out: Perceived disease threat and ideological orientations as predictors of exclusionary immigration attitudes

Integrating evolutionary and social representations theories, the current study examines the relationship between perceived disease threat and exclusionary immigration attitudes in the context of a potential avian influenza pandemic. This large‐scale disease provides a realistic context for investigating the link between disease threat and immigration attitudes. The main aim of this cross‐sectional study (N = 412) was to explore mechanisms through which perceived chronic and contextual disease threats operate on immigration attitudes. Structural equation models show that the relationship between chronic disease threat (germ aversion) and exclusionary immigration attitudes (assimilationist immigration criteria, health‐based immigration criteria and desire to reduce the proportion of foreigners) was mediated by ideological and normative beliefs (social dominance orientation, belief in a dangerous world), but not by contextual disease threat (appraisal of avian influenza pandemic threat). Contextual disease threat only predicted support for health‐based immigration criteria. The conditions under which real‐life disease threats influence intergroup attitudes are scrutinized. Convergence and dissimilarity of evolutionary and social representational approaches in accounting for the link between disease threat and immigration attitudes are discussed. Copyright © 2010 John Wiley & Sons, Ltd.     

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson’s disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing.     

Ovarian steroids and cognitive function

The ovarian steroids, estrogen and progesterone, not only govern reproductive events in mammalian females but also influence an array of other processes. Of particular clinical interest is the potential of ovarian steroids to facilitate storage of new memories and to protect neurons from various threats. Research during the past decade confirms that estrogen and progesterone influence the biochemical, electrical, and structural properties of neurons in brain regions that subserve learning and memory. These mechanisms form the biological foundations for the complex effects of ovarian steroids on cognitive functions in various species, including humans. Despite significant progress in our understanding of the roles of hormonal factors in cognitive function and neuronal survival, the value of hormone replacement as a treatment and deterrent for cognitive impairments associated with age, disease, and injury remains uncertain as we enter the new century.