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181.
Communicating genetic-risk information is fraught with difficulties, and there are no universally accepted guidelines for
clinical practice. In this paper, we suggest that information-processing models may offer some guidance for the communication
of genetic risk. The paper reviews selected literature from health and social psychology, including defensive reactions to
threatening health information, the Extended Parallel Process Model (EPPM) and Self Affirmation Theory. Ultimately, it presents
the Heuristic-Systematic Model (HSM) of information processing as a useful perspective from which to view genetic-risk communication.
Through our review of this literature, we identify some of the variables found to influence the systematic or heuristic processing
of risk information and note their relevance to genetic counseling contexts. We suggest that systematic information processing
is conducive to informed decision-making, as well as improved understanding of risk information. Clinical practice implications
derived from our review of these literatures are noted. 相似文献
182.
Dewhurst ME Veach PM Lampman C Petraitis J Kao J LeRoy B 《Journal of genetic counseling》2007,16(2):157-170
Heuristics are mental shortcuts that aid people in everyday problem-solving and decision-making. Although numerous studies
have demonstrated their use in contexts ranging from consumers’ shopping decisions to experts’ estimations of experimental
validity, virtually no published research has addressed heuristics use in problems involving genetic conditions and associated
risk probabilities. The present research consists of two studies. In the first study, 220 undergraduates attempted to solve
four genetic problems—two common heuristic problems modified to focus on genetic likelihood, and two created to study heuristics
and probability rule application. Results revealed that the vast majority of undergraduates used heuristics and also demonstrated
a complete misuse of probability rules. In the second study, 156 practicing genetic counselors and 89 genetic counseling students
solved slightly modified versions of the genetic problems used in Study 1. Results indicated that a large percentage of both
genetic counselors and students used heuristics, but the counselors demonstrated superior problem-solving performance compared
to both the genetic counseling students and the undergraduates from Study 1. Research, training, and practice recommendations
are presented. 相似文献
183.
This paper uses a broad definition of culture to explore the practice of transcultural genetic counseling through three case
studies. The first case involves a White genetic counselor seeing an Asian family, the second, an Asian genetic counselor
seeing an Asian family and the third, a hearing genetic counselor seeing a culturally Deaf client. Boundaries, transference
and countertransference reactions are considered within each transcultural encounter and the author of each case reflects
in detail on their role in the client interaction and their impact on the transcultural dynamic. The cases are used to illustrate
some cultural beliefs or characteristics that may challenge the genetic counselor’s expectations. The value of identifying
and interpreting these differences to facilitate useful clinical work is considered. The paper debates, where possible, whether
it is helpful to culturally match genetic counselor and client. 相似文献
184.
Abstract: Many techniques for automated model specification search based on numerical indices have been proposed, but no single decisive method has yet been determined. In the present article, the performance and features of the model specification search method using a genetic algorithm (GA) were verified. A GA is a robust and simple metaheuristic algorithm with great searching power. While there has already been some research applying metaheuristics to the model fitting task, we focus here on the search for a simple structure factor analysis model and propose a customized algorithm for dealing with certain problems specific to that situation. First, implementation of model specification search using a GA with factor reordering for a simple structure factor analysis is proposed. Then, through a simulation study using generated data with a known true structure and through example analysis using real data, the effectiveness and applicability of the proposed method were demonstrated. 相似文献
185.
运动、语言和学习:小脑的功能磁共振成像研究 总被引:14,自引:0,他引:14
对小脑功能的认识在过去的100年里经历了缓慢而稳定的发展。在最近20年,随着活体神经影像技术尤其是功能磁共振成像(fMRI)的出现,这一领域取得了更加显著的进展。文章简要总结了我们最近关于小脑的fMRI研究,考察了该结构在运动、语言和学习任务中的作用;并通过回顾相关文献,讨论了这些研究的理论意义。小脑的功能本质似乎是一般性的而非通道特异的,动态的而非静态的,联系的而非孤立的。作者提出,研究小脑与大脑之间的相互作用和合作机制将是小脑研究领域的新的生长点 相似文献
186.
187.
阿尔茨海默病是一种起病隐匿,进行性发展的神经系统退行性疾病。临床上以记忆障碍、失语、失用、失认、视空间损害、执行功能障碍以及人格和行为改变等全面性痴呆表现为特征,病因迄今未明,发病机制复杂。本文对可能的发病机制:遗传因素(包括ApoE基因、早老素-1和早老素-2基因,APP基因、α2巨球蛋白基因、TOMM40基因、COL25A1基因);Aβ代谢(合成、分解、转运);神经递质学说;自由基与氧化应激学说;金属离子学说等进行综述。 相似文献
188.
189.
Antonio Nicolas Puente Carlos Faraco Douglas P. Terry Courtney Brown L. Stephen Miller 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2014,21(3):346-369
This investigation compared the neural correlates of inhibition in normal older adults (OAs) and OAs with mild cognitive impairment (MCI). It was hypothesized the MCI group would require a greater amount of resources for inhibition, and therefore display greater functional activation in specific regions of interest (ROIs). Twenty-six OAs without and 17 with MCI completed the Stroop task during functional neuroimaging, and completed additional out-of-scanner neuropsychological measures. During inhibition, there were minimal functional Magnetic Resonance Imaging (fMRI) differences found between groups in a priori specified ROIs and with post-hoc multiple regression analyses. However, these minimal differences did not survive corrected thresholds. Robust differences were found with several tasks of a neuropsychological screening battery. The results of this study suggest only very minimal group differences in fMRI activation during inhibition which may not reliably identify MCI, and this condition may be best detected by traditional neuropsychological techniques. 相似文献
190.