Psychological Interventions and Genetic Testing: Facilitating Informed Decisions About BRCA1/2 Cancer Susceptibility

Genetic testing for inherited cancer susceptibility, based on the recently identified. BRCA1 and BRCA2 genes, will soon be available on a large scale. However, at present, genetic test results do not lead to clearly indicated diagnostic or preventive measures, and the nature of the psychological impact of BRCA1/2 testing is still largely unknown. This uncertainty, combined with preliminary evidence suggesting significant individual differences in reactions to genetic susceptibility feedback, constitutes a unique challenge for any individual contemplating such testing. We outline the nature of this challenge and then propose an intervention strategy designed to help individuals make deeply processed and psychologically well-informed decisions with regard to their genetic susceptibility. The intervention is guided by recent research findings and theory on the cognitive–emotional processing of cancer-risk information. Specifically, the goal is to prepare the individual for genetic testing by (1) cognitively and emotionally activating, or preliving, the individual's potential reactions to testing feedback; (2) facilitating accurate appraisal of the individual's cognitive–emotional reactions; and (3) enabling the individual to process these reactions through the use of well-established clinical techniques.     

A Leader-Led Supervision Group as a Model for Practicing Genetic Counselors

With the stage set by the overview of supervision models in the previous paper, thispaper now presents the development and evolution of a currently ongoing leader-ledsupervision group for experienced genetic counselors. I discuss the procedures forgetting started; the creation and maintenance of the contract; typical issues and themesconsidered; the format for case presentation; and the overall growth of the group and itsmembers.     

Who Is at Risk for Psychological Distress in Genetic Testing Programs for Hereditary Cancer Disorders?

Presymptomatic identification of disease gene carriers is becoming an increasingly common part of the clinical management of hereditary cancer disorders. With an expected increase in the number of requests for DNA testing and the limited resources for counseling, the amount of time genetic counselors are able to spend with test candidates will decrease. It is therefore important for counselors to identify persons at risk for psychological distress. Based on a review of experiences with Huntington disease and cancer patients, we describe factors likely to evoke distress in genetic cancer candidates. We also discuss the sometimes widely different ways that test candidates and their partners respond to genetic testing. By exploring risk factors for distress in relevant domains of the research, we can offer counselors guidelines for determining who may need extra counseling.     

Behavioral Genetics, Health, and Aging

A recurring observation from studies of health in the elderly is the pervasiveness of individual differences. For many health-related endpoints, total variation appears to increase across age group; however, few longitudinal studies have reported whether these age differences reflect true age-related changes. There are a growing number of twin studies of aging that provide some insight, at least cross-sectionally, into the nature of individual differences in health. Increases in total variance most often reflect increases in environmental sources of variance. Covariation among traits reflects both genetic and environmental mediation, dependent on the sex of the sample and the measures of interest. Co-twin control approaches have been successful in exploring the role of environmental influences as risk factors for poor health. The most serious limitation to these studies is the lack of longitudinal information to disentangle survival and selection effects from aging.     

关于进化论的生命科学质疑

现代科学远未弄清楚生命是什么,所以,肯定生命是偶然生成的观点是不符合时代的科学精神的。遗传变异不能产生新的物种,也没有证据表明基因突变导致生物进化产生了新物种。按照小群突变的新达尔文主义来推断人类进化,既缺乏事实根据,也有悖于逻辑推理。     

迎接生物学世纪的曙光

现代生物工程技术是以基因工程、细胞工程、发酵工程酶工程为主体的高新技术。生产工程产业主要包括生物工程药业和生物工程农业两个重要部分。生物工程产业化都需要经过研究、开发、产业化和商业化四个步骤。生物工程产业发展经过了生物工程技术的突破阶段、完善和产业化的开始阶段、大规模产业化的开始阶段、大规模产业化的成熟阶段。其中第三阶段对我国的生物工程产业来说是为关键的。知识产权机会、商业机会为这个阶段我国生物工     

Attitudes toward genetic counseling and prenatal diagnosis among a group of individuals with physical disabilities

Few studies have been published on the attitudes of people with physical disabilities toward genetic counseling and prenatal diagnosis. Articles in the lay press and social science literature on this topic, mainly written by disability rights activists and advocates, imply opposition to prenatal diagnosis and the field of clinical genetics by the physically disabled population. In this study, 15 adults with physical disabilities were interviewed regarding their attitudes toward genetic counseling and prenatal diagnosis. Genetic counseling and prenatal diagnosis were generally viewed favorably by this sample of the disability community. Only a small percentage of the sample perceived genetics to be eugenic. Implications for genetic counseling and future research are discussed.     

Genetic and Environmental Influences on Psychopathy Trait Dimensions in a Community Sample of Male Twins

Psychopathy appears to be comprised of two broad dimensions: impulsivity/antisocial behavior and interpersonal detachment/callousness. This study examined the extent to which variance in these 2 psychopathy trait dimensions was associated with common or unique genetic, shared, and nonshared environmental factors in two independent samples of reared together 16–18-year-old male twins. One sample included 142 monozygotic (MZ) and 70 dizygotic (DZ) pairs; the other sample included 128 MZ and 58 DZ pairs. Boys completed the Minnesota Temperament Inventory (MTI), a 19-item measure that contains separate subscales: Antisocial and Detachment. Variance in the Antisocial and Detachment scales was associated with additive genetic factors and neither scale was associated with shared environmental factors. As expected, the bivariate biometric analysis suggested genetic influence on the covariance of the scales. The results are consistent with theoretical models of psychopathy that posit some independence in the etiology of the two major trait dimensions of psychopathy.     

Metaphors in behavioral genetics

Behavioral geneticists sometimes use metaphorsto describe the role of genes in humanbehavior. In this paper, five sample texts areanalyzed: a popular book, a textbook, ascientific review article, and two originalscientific articles representing differentapproaches in behavioral genetics. Metaphorsare found in all the different kinds of sampletexts, not only in the popular book and thetextbook. This suggests that metaphors are usednot only for rhetorical or pedagogical purposesbut play a more fundamental role in scientificunderstanding. In the sample texts, themetaphors tend to be antideterministic, i.e.,they do not imply genetic determinism butstress the interaction of multiple genes andmultiple environmental factors. No conclusioncan be drawn, however, as to whetherantideterminism is representative ofpresent-day behavioral geneticists in general.Certain historically important metaphors thatmay imply genetic determinism are qualified,avoided, or explicitly rejected. There aretensions between some of the metaphors, makingthem difficult to combine. All the metaphorsthat are used appear empirically apt, howeversometimes only with certain qualifications.     

Embodied Knowledge and Making Sense of Prenatal Diagnosis

Open-ended, qualitative interviews with women to whom amniocentesis was offered were analyzed to understand how women made sense of these tests. We found that women, whether tested or not, negotiated with biomedical information. They transformed it through identifiable processes, then wove it with their own instincts and beliefs and with their personal experiences, thereby creating embodied knowledge on which their decisions were based. Women who were and were not tested may have differed from each other when categorized on the basis of a final, binary choice, but they were more alike than unalike in reaching this point. The apparent importance of embodied knowledge suggests the critical role of the listening activities of the genetic counselor and of awareness of the validity and importance of women's complementary ways of knowing and doing in understanding the uses and meanings of prenatal genetic testing.