全文获取类型
收费全文 | 531篇 |
免费 | 13篇 |
国内免费 | 17篇 |
出版年
2024年 | 2篇 |
2023年 | 3篇 |
2021年 | 2篇 |
2020年 | 12篇 |
2019年 | 8篇 |
2018年 | 12篇 |
2017年 | 6篇 |
2016年 | 7篇 |
2015年 | 9篇 |
2014年 | 11篇 |
2013年 | 43篇 |
2012年 | 8篇 |
2011年 | 8篇 |
2010年 | 2篇 |
2009年 | 9篇 |
2008年 | 13篇 |
2007年 | 46篇 |
2006年 | 43篇 |
2005年 | 39篇 |
2004年 | 13篇 |
2003年 | 28篇 |
2002年 | 33篇 |
2001年 | 28篇 |
2000年 | 36篇 |
1999年 | 21篇 |
1998年 | 21篇 |
1997年 | 15篇 |
1996年 | 12篇 |
1995年 | 12篇 |
1994年 | 18篇 |
1993年 | 13篇 |
1992年 | 14篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1987年 | 4篇 |
1985年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有561条查询结果,搜索用时 15 毫秒
111.
Providing medical management updates and long-term support to families with hereditary cancer syndromes in rural areas is
a challenge. To address this, we designed a one-day retreat for BRCA1/2 carriers in our region. The retreat included educational updates about medical management, genetic privacy and discrimination,
and addressed psychological and family issues. Evaluations completed at the conclusion of the retreat were overwhelmingly
positive with requests for a similar event in the future. The impact of this retreat on a variety of health behaviors was
assessed. Eligible participants completed questionnaires before and 6 months after the retreat. Questionnaires focused on
lifestyle, cancer screening and prevention practices, psychological history and distress, decision-making regarding genetic
testing, and family communication issues. For individuals who completed both the pre and post retreat questionnaires, one-half
made lifestyle changes and nearly two-thirds increased cancer screening, initiated chemoprevention, completed or planned to
complete preventative surgery in the future. We conclude that this type of forum provides a valuable opportunity for BRCA carriers and their families to receive updated medical information, share personal experiences, provide and receive support,
as well as change health behaviors. 相似文献
112.
Palmero EI Ashton-Prolla P da Rocha JC Vargas FR Kalakun L Blom MB Azevedo SJ Caleffi M Giugliani R Schüler-Faccini L 《Journal of genetic counseling》2007,16(3):363-371
Hereditary breast cancer (HBC) accounts for 5–10% of breast cancer cases and it significantly increases the lifetime risk
of cancer. Our objective was to evaluate the sociodemographic variables, family history of cancer, breast cancer (BC) screening
practices and the risk profile of cancer affected or asymptomatic at-risk women that undergo genetic counseling for hereditary
breast cancer in public Brazilian cancer genetics services. Estimated lifetime risk of BC was calculated for asymptomatic
women using the Gail and Claus models. The majority of women showed a moderate lifetime risk of developing BC, with an average
risk of 19.7% and 19.9% by the Gail and Claus models, respectively. The average prior probability of carrying a BRCA1/2 gene mutation was 16.7% and overall only 32% fulfilled criteria for a hereditary breast cancer syndrome as assessed by family
history. We conclude that a significant number of individuals at high-risk for HBC syndromes may not have access to the benefits
of cancer genetic counseling in these centers. Contributing factors may include insufficient training of healthcare professionals,
disinformation of cancer patients; difficult access to genetic testing and/or resistance in seeking such services. The identification
and understanding of these barriers is essential to develop specific strategies to effectively achieve cancer risk reduction
in this and other countries were clinical cancer genetics is not yet fully established. 相似文献
113.
Strømsvik N Nordin K Berglund G Engebretsen LF Hansson MG Gjengedal E 《Journal of genetic counseling》2007,16(1):105-117
This qualitative study explores how 29 Swedish patients with Multiple Endocrine Neoplasia type 1 (MEN1) experience living
with the condition, appraisal of the clinical follow-up program, and surveys their future expectations. The aim of this study
is to build knowledge about this patient group in order to provide optimal care. The participants describe physical, psychological,
and social limitations in their daily activities and how these limitations influence quality of life. Our findings indicate
that a majority of patients have adjusted to their situation, describing themselves as being healthy despite physical symptoms
and treatment. The participants received decent care in the clinical follow-up program, - however, greater effort should be
put into patient information. These patients might benefit from genetic counseling. Health professionals involved should recognize
their potential impact and influence on a patient’s ability to adjust to these circumstances. Antonovsky`s Sense of Coherence
theory is used to discuss these findings. 相似文献
114.
Utilization of cancer genetic risk assessment can be profoundly influenced by an individuals’ knowledge of risk assessment,
attitudes regarding illness and healthcare, and affective reactions derived from social norms. Race and ethnicity play a powerful
role in the development of an individual's attitudes and should be considered when attempting to understand a person's openness
to cancer genetic risk assessment (Lannin et al., 1998). Until recently, however, cancer screening and prevention programs have been primarily based on data from studies
conducted with the Caucasian population, yielding data that are not fully applicable to the African American community. In
the last several years, research findings regarding African American's knowledge, attitudes, and feelings about genetic counseling
and testing have grown (Matthews et al., 2000; Singer et al., 2004; Thompson et al., 2003). However, to the authors’ knowledge, these data have yet to be presented in a manner that both summarizes the barriers
that African Americans have reported regarding cancer genetic risk assessment, while at the same time suggesting methods individual
genetic counselors can utilize during community presentations to help address these barriers. This article will first summarize
previous empirical findings regarding African Americans’ knowledge, attitudes, and feelings about cancer genetic risk assessment.
The article will then apply adult learning theory to those findings to provide genetic counselors with practical, theory based
techniques to apply toward community based educational programs with African American groups. 相似文献
115.
Neal Judisch 《The Journal of Ethics》2007,11(4):357-375
John Martin Fischer and Mark Ravizza offer a theory of moral responsibility which makes responsibility dependent upon the
way in which moral agents view themselves. According to the theory, agents are responsible for their actions only if they
think of themselves as apt candidates for praise and blame; if they come to believe they are not apt candidates for praise
and blame, they are ipso facto not morally responsible. In what follows, I show that Fischer and Ravizza’s account of responsibility for consequences is
inconsistent with this subjective element of their theory, and that the subjective element may be retained only if they are
willing to implausibly restrict their account of responsibility for consequences. I end by discussing the broad significance
of the failure of the subjective element for their overall approach to moral responsibility. 相似文献
116.
Imtiaz Moosa 《Ethical Theory and Moral Practice》2007,10(2):159-182
In this article (1) I extract from Brentano’s works (three) formal arguments against “genealogical explanations” of ethical
claims. Such explanation can also be designated as “naturalism” (not his appellation); (2) I counter these arguments, by showing
how genealogical explanations of even apodictic moral claims are logically possible (albeit only if certain unlikely, stringent
conditions are met); (3) I show how Nietzsche’s ethics meets these stringent conditions, but evolutionary ethics does not.
My more general thesis is that naturalism and intuitionism in ethics need not be mutually incompatible.
相似文献
Imtiaz MoosaEmail: |
117.
Mark Balaguer 《Synthese》2009,168(1):1-21
This paper considers the empirical evidence that we currently have for various kinds of determinism that might be relevant
to the thesis that human beings possess libertarian free will. Libertarianism requires a very strong version of indeterminism,
so it can be refuted not just by universal determinism, but by some much weaker theses as well. However, it is argued that
at present, we have no good reason to believe even these weak deterministic views and, hence, no good reason—at least from
this quarter—to doubt that we are libertarian free. In particular, the paper responds to various arguments for neural and
psychological determinism, arguments based on the work of people like Honderich, Tegmark, Libet, Velmans, Wegner, and Festinger. 相似文献
118.
有关进化心理学局限性的理论思考 总被引:4,自引:0,他引:4
进化心理学是现代西方心理学的新取向之一。这一新取向吸引了众多的追随者,但是它自身的核心假设、方法论和认识论方面却存在着局限性。文章从三个方面分析了这种局限性:第一,进化心理学的核心假设是心理的模块性观点。依据这种观点,心灵由大量功能各异的心理模块组成,但是来自于心理学和生物学的研究都表明这种观点是缺乏科学依据的。第二,进化心理学从过去的角度理解现在,所依据的事实大多是推测性的,更多的是一种历史叙事,从方法论的角度来说,这种研究不具备可证伪性,不符合科学方法论的基本原则。第三,在认识论方面,进化心理学继承了社会生物学的传统,有意或无意地夸大了基因的作用,贬低了个体发展过程中其它因素,现代生命科学的研究已经证明了基因决定论的虚假性 相似文献
119.
David Reiss 《心理学报》2008,40(10):1099-1105
双生子与养子女的研究尤其能对环境影响的机制提供证据。本文扼要地概述了“非共享环境与青少年发展”(NEAD)计划的部分研究成果,特别是子代对父代影响的成果,同时本文也讨论了今后计量行为遗传学的可能走向 相似文献
120.
基因检测与治疗中若干问题的伦理学思考 总被引:4,自引:0,他引:4
林辉 《医学与哲学(人文社会医学版)》2001,22(5):10-13
随着基因组学的发展,临床医学中出现了基因检测与基因治疗的新方法,伴随着基因技术的临床应用出现了一些伦理、法律和社会新问题,迫使人们从理论和观念层次加以考察并探讨解决问题的可能性途径,对基因检测和基因治疗中出现或可能出现的伦理学问题进行了初步探讨,结合国际人类基因组计划的有关规范,探索了解决问题的可能性途径。 相似文献