The Nature and Significance of Behavioural Genetic Information

In light of the human genome project, establishing the genetic aetiology of complex human diseases has become a research priority within Western medicine. However, in addition to the identification of disease genes, numerous research projects are also being undertaken to identify genes contributing to the development of human behavioural characteristics, such as cognitive ability and criminal tendency. The permissibility of this research is obviously controversial: will society benefit from this research, or will it adversely affect our conceptions of ourselves and each other? When assessing the permissibility of this research, it is important to consider the nature and deterministic significance of behavioural genetic information. Whilst todate there has been much discussion and debate about the properties of genetic information per se and genetic determinism, this has not been applied to behavioural genetic research and its ethical implications. Therefore, this paper elucidates how behavioural genetic information can be distinguished from other types of genetic and non-genetic information and also synthesises the determinative significance of genetic factors for the development of human behavioural traits. Undertaking this analysis enables the ethical issues raised by this research to be debated in an appropriate context and indicates that separate policy considerations are warranted.

     

评发生认识论的"反省抽象"范畴

论文分析了皮亚杰发生认识论中“反省抽象”范畴的发展脉络、主要内涵及其与某些相关概念(如概括化、平衡化、矛盾与否定的构造、意识化与觉知等)的联系。作者认为：反省抽象不仅体现皮亚杰的独创性．而且也是发生认识沦中最为核心和最为重要的概念。它合理地解释了知识创新的源泉,使发生认识论的逻辑一数学范畴研究及认知发展一般规律的研究奠基于科学认识论之上。作者主张应准确继承皮亚杰的学术遗产,深化对认知发展机制的探索。     

Science and Human Behavior: a tutorial in behavior analysis

B. F. Skinner's Science and Human Behavior (1953) became the main source of my understanding of behavior during my first semester as a college professor in 1955 at Kansas University. It has continued to exert a major influence throughout my career as the basis for a completely deterministic science of behavior, as a handbook to be consulted as a first step in dealing with any issue in behavior analysis, and as a tutorial in behavioral interpretive analysis--in the use of a small number of behavioral concepts and principles to understand behavior of all degrees of complexity. I describe four general interpretive orientations or maxims that are of broad significance for behavior analysis, and also two underappreciated major theoretical contributions.     

Tucker3 hierarchical classes analysis

This paper presents a new model for binary three-way three-mode data, called Tucker3 hierarchical classes model (Tucker3-HICLAS). This new model generalizes Leenen, Van Mechelen, De Boeck, and Rosenberg's (1999) individual differences hierarchical classes model (INDCLAS). Like the INDCLAS model, the Tucker3-HICLAS model includes a hierarchical classification of the elements of each mode, and a linking structure among the three hierarchies. Unlike INDCLAS, Tucker3-HICLAS (a) does not restrict the hierarchical classifications of the three modes to have the same rank, and (b) allows for more complex linking structures among the three hierarchies. An algorithm to fit the Tucker3-HICLAS model is described and evaluated in an extensive simulation study. An application of the model to hostility data is discussed.The first author is a Research Assistant of the Fund for Scientific Research-Flanders (Belgium). The research reported in this paper was partially supported by the Research Council of K.U. Leuven (GOA/2000/02). We are grateful to Kristof Vansteelandt for providing us with an interesting data set.     

Genetic and Environmental Influences on Psychopathy Trait Dimensions in a Community Sample of Male Twins

Psychopathy appears to be comprised of two broad dimensions: impulsivity/antisocial behavior and interpersonal detachment/callousness. This study examined the extent to which variance in these 2 psychopathy trait dimensions was associated with common or unique genetic, shared, and nonshared environmental factors in two independent samples of reared together 16–18-year-old male twins. One sample included 142 monozygotic (MZ) and 70 dizygotic (DZ) pairs; the other sample included 128 MZ and 58 DZ pairs. Boys completed the Minnesota Temperament Inventory (MTI), a 19-item measure that contains separate subscales: Antisocial and Detachment. Variance in the Antisocial and Detachment scales was associated with additive genetic factors and neither scale was associated with shared environmental factors. As expected, the bivariate biometric analysis suggested genetic influence on the covariance of the scales. The results are consistent with theoretical models of psychopathy that posit some independence in the etiology of the two major trait dimensions of psychopathy.     

Shackling the shoulders of giants

This paper informally summarizes a two-day symposium held at the U.S. National Academy of Sciences in Washington, D.C., September 5–6, 2002. The issue was to what extent the progress of science and societal capacity for continued technological innovation are threatened by excessive protection of intellectual property. Excessive protection creates disadvantages not only for scientists and inventors but also for educators/students and for librarians/clientele. Speakers from a variety of disciplines and institutions agreed unanimously that scientific and technological progress is, indeed, under serious threat. Various opinions were expressed about the degree of threat, currently and prospectively, as well as what counter-measures are best suited to resist undue restrictions on creative uses of scientific and technical data and information. This summary is based entirely on the author’s notes from the symposium, and the commentary offered is his alone. My apologies to the speakers if this paper does not accurately reflect the primary intent of their presentations. The “Suggested Readings” offered at the end are not specific to the speakers’ statements but rather are offered as a general resource to aid further research. The definitive record of the symposium is planned to be available from the National Academies Press as a Proceedings publication in the summer of 2003. John Gardenier is an independent researcher, ethicist and science writer.     

Metaphors in behavioral genetics

Behavioral geneticists sometimes use metaphorsto describe the role of genes in humanbehavior. In this paper, five sample texts areanalyzed: a popular book, a textbook, ascientific review article, and two originalscientific articles representing differentapproaches in behavioral genetics. Metaphorsare found in all the different kinds of sampletexts, not only in the popular book and thetextbook. This suggests that metaphors are usednot only for rhetorical or pedagogical purposesbut play a more fundamental role in scientificunderstanding. In the sample texts, themetaphors tend to be antideterministic, i.e.,they do not imply genetic determinism butstress the interaction of multiple genes andmultiple environmental factors. No conclusioncan be drawn, however, as to whetherantideterminism is representative ofpresent-day behavioral geneticists in general.Certain historically important metaphors thatmay imply genetic determinism are qualified,avoided, or explicitly rejected. There aretensions between some of the metaphors, makingthem difficult to combine. All the metaphorsthat are used appear empirically apt, howeversometimes only with certain qualifications.     

Case Report: Object Relations Family Therapy as a Model for Genetic Counseling

Object relations family therapy (ORFT) is a psychoanalytically based approach for the treatment of couples and families which stresses the importance of past relationships. The therapist assumes a parentlike role and provides a holding environment in which clients can explore unconscious motivations. This paper will discuss the applicability of this method to genetic counseling. The case of a couple seen for recurrent trisomies will be presented and used as an example to discuss how ORFT might serve as a framework in a genetic counseling session.     

Client Advocacy and Collaboration with Insurance and Laboratory Testing Agencies: A Case Study Illustrating Genetic Counselor Roles

Genetic counseling and the many roles a genetic counselor must assume to provide quality genetic health care are becoming increasingly complex, especially when the genetic condition is rare, and DNA testing is costly and not yet routinely used. A case study of a couple with a family history of retinoblastoma and their pursuit of DNA testing for prenatal diagnosis is presented. The case study illustrates the instrumental role of the genetic counselor in advocating for clients for genetic services such as DNA testing and in educating insurance companies in the nature and importance of such services to achieve improved client health care outcomes.